2,2-dialkylglycine + pyruvate dialkyl ketone + CO2 + L-alanine
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,2-dialkylglycine carboxy-lyase (amino-transferring L-alanine-forming). Other names in common use include dialkyl amino acid (pyruvate) decarboxylase, alpha-dialkyl amino acid transaminase, 2,2-dialkyl-2-amino acid-pyruvate aminotransferase, L-alanine-alpha-ketobutyrate aminotransferase, dialkylamino-acid decarboxylase (pyruvate), and 2,2-dialkylglycine carboxy-lyase (amino-transferring). It employs one cofactor, pyridoxal phosphate.
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid. They are important in the synthesis of amino acids, which form proteins.
Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.
The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction
The enzyme aspartate 1-decarboxylase (EC 4.1.1.11) catalyzes the chemical reaction
In enzymology, an aspartate 4-decarboxylase (EC 4.1.1.12) is an enzyme that catalyzes the chemical reaction
The enzyme sulfinoalanine decarboxylase (EC 4.1.1.29) catalyzes the chemical reaction
In enzymology, a 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a 2-aminoethylphosphonate—pyruvate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, 4-aminobutyrate transaminase, also called GABA transaminase or 4-aminobutyrate aminotransferase, or GABA-T, is an enzyme that catalyzes the chemical reaction:
In enzymology, an alanine-oxo-acid transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, an alanine-oxomalonate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, an aminolevulinate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a beta-alanine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a cephalosporin-C transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a D-amino-acid transaminase is an enzyme that catalyzes the chemical reaction:
In enzymology, a diaminobutyrate-pyruvate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a glutamine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a (R)-3-amino-2-methylpropionate—pyruvate transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a valine-pyruvate transaminase is an enzyme that catalyzes the chemical reaction
References
Bailey GB, Dempsey WB (1967). "Purification and properties of an alpha-dialkyl amino acid transaminase". Biochemistry. 6 (5): 1526–1533. doi:10.1021/bi00857a039.
This page is based on this Wikipedia article Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses.
