| Game Log |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 1 | April 1 | @ Reds | 3–1 (13) | Lowe (1–0) | Hoover (0–1) | Frieri (1) | 43,168 | 1–0 | 4h 44m | W1 | | 2 | April 3 | @ Reds | 4–5 | Chapman (1–0) | Downs (0–1) | | 35,257 | 1–1 | 3h 06m | L1 | | 3 | April 4 | @ Reds | 4–5 | Arroyo (1–0) | Blanton (0–1) | Chapman (1) | 23,795 | 1–2 | 2h 51m | L2 | | 4 | April 5 | @ Rangers | 2–3 | Scheppers (1–0) | Downs (0–2) | Nathan (1) | 48,845 | 1–3 | 2h 46m | L3 | | 5 | April 6 | @ Rangers | 8–4 | Hanson (1–0) | Harrison (0–2) | | 47,201 | 2–3 | 3h 00m | W1 | | 6 | April 7 | @ Rangers | 3–7 | Darvish (2–0) | Weaver (0–1) | | 42,034 | 2–4 | 3h 01m | L1 | | 7 | April 9 | Athletics | 5–9 | Cook (1–0) | Jepsen (0–1) | | 44,014 | 2–5 | 3h 44m | L3 | | 8 | April 10 | Athletics | 5–11 | Milone (2–0) | Blanton (0–2) | | 36,011 | 2–6 | 3h 47m | L4 | | 9 | April 11 | Athletics | 1–8 | Griffin (2–0) | Vargas (0–1) | | 43,533 | 2–7 | 2h 59m | L5 | | 10 | April 12 | Astros | 0–5 | Norris (2–1) | Hanson (1–1) | | 37,674 | 2–8 | 3h 23m | L6 | | 11 | April 13 | Astros | 4–5 | Roth (1–0) | Veras (0–1) | | 43,520 | 3–8 | 3h 10m | W1 | | 12 | April 14 | Astros | 4–1 | Wilson (1–0) | Humber (0–3) | Frieri (2) | 36,126 | 4–8 | 3h 03m | W2 | | 13 | April 15 | @ Twins | 2–8 | Correia (1–1) | Blanton (0–3) | | 23,535 | 4–9 | 2h 49m | L1 | | 14 | April 16 | @ Twins | 6–8 | Pelfrey (2–1) | Vargas (0–2) | Perkins (3) | 23,299 | 4–10 | 3h 30m | L2 | | – | April 17 | @ Twins | Postponed (rain). Makeup date September 9th. | | 15 | April 19 | Tigers | 8–1 | Hanson (2–1) | Sánchez (2–1) | | 39,023 | 5–10 | 3h 04m | W1 | | 16 | April 20 | Tigers | 10–0 | Richards (1–0) | Porcello (0–2) | | 35,081 | 6–10 | 2h 52m | W2 | | 17 | April 21 | Tigers | 4–3 (13) | Williams (1–0) | Coke (0–2) | | 41,147 | 7–10 | 4h 28m | W3 | | 18 | April 22 | Rangers | 6–7 | Scheppers (2–0) | Frieri (0–1) | Nathan (6) | 36,192 | 7–11 | 3h 07m | L1 | | 19 | April 23 | Rangers | 5–4 (11) | De La Rosa (1–0) | Ortiz (2–1) | | 35,353 | 8–11 | 3h 13m | W1 | | 20 | April 24 | Rangers | 3–11 | Darvish (4–1) | Roth (1–1) | | 37,154 | 8–12 | 3h 22m | L1 | | 21 | April 25 | @ Mariners | 0–6 | Maurer (2–3) | Richards (1–1) | | 13,000 | 8–13 | 2h 29m | L2 | | 22 | April 26 | @ Mariners | 6–3 | Wilson (2–0) | Harang (0–3) | Frieri (3) | 31,543 | 9–13 | 3h 34m | W1 | | 23 | April 27 | @ Mariners | 2–3 | Hernández (3–2) | Blanton (0–4) | Wilhelmsen (7) | 31,901 | 9–14 | 2h 37m | L1 | | 24 | April 28 | @ Mariners | 1–2 | Capps (2–1) | Vargas (0–3) | Wilhelmsen (8) | 20,638 | 9–15 | 2h 31m | L2 | | 25 | April 29 | @ Athletics | 8–10 (19) | Blevins (2–0) | Enright (0–1) | | 11,668 | 9–16 | 6h 32m | L3 | | 26 | April 30 | @ Athletics | 6–10 | Parker (1–4) | Richards (1–2) | | 14,764 | 9–17 | 3h 39m | L4 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 27 | May 1 | @ Athletics | 5–4 | Wilson (3–0) | Milone (3–3) | Frieri (4) | 17,139 | 10–17 | 3h 35m | W1 | | 28 | May 2 | Orioles | 1–5 | Tillman (2–1) | Blanton (0–5) | | 35,118 | 10–18 | 2h 28m | L1 | | 29 | May 3 | Orioles | 4–0 | Vargas (1–3) | González (2–2) | | 40,140 | 11–18 | 2h 15m | W1 | | 30 | May 4 | Orioles | 4–5 (10) | Hunter (1–1) | Richards (1–3) | Johnson (11) | 32,136 | 11–19 | 3h 43m | L1 | | 31 | May 5 | Orioles | 4–8 | Hammel (5–1) | Williams (1–1) | O'Day (1) | 38,047 | 11–20 | 3h 34m | L2 | | 32 | May 7 | @ Astros | 6–7 | Lyles (1–0) | Wilson (3–1) | Veras (3) | 15,266 | 11–21 | 2h 45m | L3 | | 33 | May 8 | @ Astros | 1–3 | Norris (4–3) | Blanton (0–6) | Veras (4) | 12,906 | 11–22 | 2h 30m | L4 | | 34 | May 9 | @ Astros | 6–5 | Richards (2–3) | Ambriz (0–2) | Frieri (5) | 13,003 | 12–22 | 4h 07m | W1 | | 35 | May 10 | @ White Sox | 7–5 | Kohn (1–0) | Axelrod (0–3) | Frieri (6) | 22,638 | 13–22 | 3h 35m | W2 | | 36 | May 11 | @ White Sox | 3–2 | Williams (2–1) | Quintana (2–1) | Frieri (7) | 28,774 | 14–22 | 2h 48m | W3 | | 37 | May 12 | @ White Sox | 0–3 | Sale (4–2) | Wilson (3–2) | | 22,088 | 14–23 | 2h 32m | L1 | | 38 | May 13 | Royals | 4–11 | Mendoza (1–2) | Blanton (0–7) | Hochevar (1) | 32,203 | 14–24 | 3h 07m | L2 | | 39 | May 14 | Royals | 6–2 | Vargas (2–3) | Guthrie (5–1) | | 33,028 | 15–24 | 2h 32m | W1 | | 40 | May 15 | Royals | 5–9 | Davis (3–3) | Enright (0–2) | | 31,917 | 15–25 | 3h 36m | L1 | | 41 | May 16 | White Sox | 4–5 | Lindstrom (2–2) | De La Rosa (1–1) | Reed (13) | 37,711 | 15–26 | 3h 08m | L2 | | 42 | May 17 | White Sox | 0–3 | Sale (5–2) | Wilson (3–3) | Reed (14) | 37,546 | 15–27 | 2h 48m | L3 | | 43 | May 18 | White Sox | 12–9 | Coello (1–0) | Jones (0–4) | Frieri (8) | 37,165 | 16–27 | 3h 50m | W1 | | 44 | May 19 | White Sox | 6–2 | Vargas (3–3) | Peavy (5–2) | Frieri (9) | 38,190 | 17–27 | 3h 04m | W2 | | 45 | May 21 | Mariners | 12–0 | Williams (3–1) | Harang (1–5) | | 34,095 | 18–27 | 2h 47m | W3 | | 46 | May 22 | Mariners | 7–1 | Wilson (4–3) | Maurer (2–6) | | 33,313 | 19–27 | 2h 44m | W4 | | 47 | May 23 | @ Royals | 5–4 | Blanton (1–7) | Santana (3–4) | Coello (1) | 18,784 | 20–27 | 2h 55m | W5 | | 48 | May 24 | @ Royals | 5–2 | Vargas (4–3) | Hochevar (0–1) | Richards (1) | 32,148 | 21–27 | 3h 01m | W6 | | 49 | May 25 | @ Royals | 7–0 | Buckner (1–0) | Guthrie (5–3) | | 27,958 | 22–27 | 2h 44m | W7 | | 50 | May 26 | @ Royals | 5–2 | Williams (4–1) | Davis (3–4) | Frieri (10) | 24,475 | 23–27 | 3h 38m | W8 | | 51 | May 27 | @ Dodgers | 7–8 | Belisario (3–4) | Coello (1–1) | League (11) | 49,953 | 23–28 | 3h 37m | L1 | | 52 | May 28 | @ Dodgers | 0–3 | Ryu (6–2) | Blanton (1–8) | | 46,433 | 23–29 | 2h 11m | L2 | | 53 | May 29 | Dodgers | 4–3 | Weaver (1–1) | Capuano (1–4) | Frieri (11) | 39,172 | 24–29 | 2h 50m | W1 | | 54 | May 30 | Dodgers | 3–2 | Vargas (5–3) | Lilly (0–2) | Frieri (12) | 42,231 | 25–29 | 2h 45m | W2 | | 55 | May 31 | Astros | 3–6 | Keuchel (2–2) | Hanson (2–2) | Veras (9) | 34,401 | 25–30 | 3h 10m | L1 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 56 | June 1 | Astros | 0–2 | Norris (5–4) | Williams (4–2) | Veras (10) | 40,087 | 25–31 | 3h 14m | L2 | | 57 | June 2 | Astros | 4–5 | Lyles (3–1) | Wilson (4–4) | Ambriz (2) | 35,515 | 25–32 | 3h 19m | L3 | | 58 | June 3 | Astros | 1–2 | Bédard (1–2) | Blanton (1–9) | Veras (11) | 30,010 | 25–33 | 2h 38m | L4 | | 59 | June 4 | Cubs | 4–3 | Coello (2–1) | Villanueva (1–4) | Frieri (13) | 32,223 | 26–33 | 3h 01m | W1 | | 60 | June 5 | Cubs | 6–8 (10) | Gregg (2–0) | Coello (2–2) | | 30,171 | 26–34 | 4h 14m | L1 | | – | June 7 | @ Red Sox | Postponed (rain). Makeup Date June 8. | | 61 | June 8 | @ Red Sox | 9–5 | Hanson (3–2) | Doubront (4–3) | Frieri (14) | 34,499 | 27–34 | 4h 00m | W1 | | 62 | June 8 | @ Red Sox | 2–7 | Buchholz (9–0) | Wilson (4–5) | | 36,518 | 27–35 | 3h 25m | L1 | | 63 | June 9 | @ Red Sox | 5–10 | Dempster (4–6) | Blanton (1–10) | | 37,054 | 27–36 | 3h 33m | L2 | | 64 | June 10 | @ Orioles | 3–4 | García (3–3) | Weaver (1–2) | Johnson (22) | 15,514 | 27–37 | 2h 23m | L3 | | 65 | June 11 | @ Orioles | 2–3 | González (4–2) | Vargas (5–4) | Johnson (23) | 22,834 | 27–38 | 2h 42m | L4 | | 66 | June 12 | @ Orioles | 9–5 | Williams (5–2) | Strop (0–3) | | 25,964 | 28–38 | 3h 13m | W1 | | 67 | June 14 | Yankees | 5–2 | Wilson (5–5) | Pettitte (5–4) | Frieri (15) | 40,621 | 29–38 | 2h 53m | W2 | | 68 | June 15 | Yankees | 6–2 | Hanson (4–2) | Phelps (4–4) | | 40,486 | 30–38 | 3h 10m | W3 | | 69 | June 16 | Yankees | 5–6 | Sabathia (7–5) | Weaver (1–3) | Rivera (24) | 41,204 | 30–39 | 2h 58m | L1 | | 70 | June 17 | Mariners | 11–3 | Vargas (6–4) | Harang (3–7) | | 30,258 | 31–39 | 2h 56m | W1 | | 71 | June 18 | Mariners | 2–3 (10) | Furbush (1–3) | Richards (2–4) | Medina (1) | 33,040 | 31–40 | 3h 42m | L1 | | 72 | June 19 | Mariners | 1–0 | Wilson (6–5) | Saunders (5–7) | Frieri (16) | 35,401 | 32–40 | 2h 27m | W1 | | 73 | June 20 | Mariners | 10–9 | Downs (1–2) | Capps (2–2) | Frieri (17) | 37,711 | 33–40 | 3h 36m | W2 | | 74 | June 21 | Pirates | 2–5 | Cole (3–0) | Weaver (1–4) | Grilli (26) | 40,136 | 33–41 | 2h 55m | L1 | | 75 | June 22 | Pirates | 1–6 | Liriano (6–3) | Williams (5–3) | | 41,114 | 33–42 | 2h 52m | L2 | | 76 | June 23 | Pirates | 9–10 (10) | Melancon (2–1) | Jepsen (0–2) | | 35,069 | 33–43 | 3h 55m | L3 | | 77 | June 25 | @ Tigers | 14–8 | Wilson (7–5) | Porcello (4–5) | | 34,402 | 34–43 | 4h 03m | W1 | | 78 | June 26 | @ Tigers | 7–4 | De La Rosa (2–1) | Álvarez (1–1) | Frieri (18) | 35,635 | 35–43 | 3h 06m | W2 | | 79 | June 27 | @ Tigers | 3–1 (10) | Jepsen (1–2) | Coke (0–5) | Frieri (19) | 39,496 | 36–43 | 3h 25m | W3 | | 80 | June 28 | @ Astros | 4–2 | De La Rosa (3–1) | Clemens (4–3) | Frieri (20) | 20,498 | 37–43 | 3h 49m | W4 | | 81 | June 29 | @ Astros | 7–2 | Blanton (2–10) | Lyles (4–3) | | 26,650 | 38–43 | 3h 01m | W5 | | 82 | June 30 | @ Astros | 3–1 | Wilson (8–5) | Cisnero (2–1) | Frieri (21) | 22,361 | 39–43 | 3h 08m | W6 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 83 | July 2 | Cardinals | 5–1 | Weaver (2–4) | Lynn (10–3) | | 39,455 | 40–43 | 2h 40m | W7 | | 84 | July 3 | Cardinals | 2–12 | Miller (9–6) | Williams (5–4) | | 35,025 | 40–44 | 3h 22m | L1 | | 85 | July 4 | Cardinals | 6–5 | Downs (2–2) | Mujica (0–1) | | 42,707 | 41–44 | 2h 51m | W1 | | 86 | July 5 | Red Sox | 2–6 | Doubront (5–3) | Wilson (8–6) | | 37,092 | 41–45 | 3h 14m | L1 | | 87 | July 6 | Red Sox | 9–7 (11) | De La Rosa (4–1) | Breslow (2–2) | | 36,112 | 42–45 | 4h 22m | W1 | | 88 | July 7 | Red Sox | 3–0 | Weaver (3–4) | Lackey (6–6) | Frieri (22) | 39,018 | 43–45 | 2h 57m | W2 | | 89 | July 9 | @ Cubs | 2–7 | Wood (6–6) | Blanton (2–11) | | 31,579 | 43–46 | 2h 43m | L1 | | 90 | July 10 | @ Cubs | 13–2 | Wilson (9–6) | Samardzija (5–9) | | 31,111 | 44–46 | 3h 04m | W1 | | 91 | July 12 | @ Mariners | 3–8 | Saunders (8–8) | Williams (5–5) | | 21,372 | 44–47 | 2h 45m | L1 | | 92 | July 13 | @ Mariners | 0–6 | Hernández (10–4) | Weaver (3–5) | | 32,458 | 44–48 | 2h 57m | L2 | | 93 | July 14 | @ Mariners | 3–4 | Iwakuma (8–4) | Blanton (2–12) | Wilhelmsen (19) | 25,629 | 44–49 | 2h 51m | L3 | | All-Star Break : AL defeats NL 3–0 | | 94 | July 19 | Athletics | 4–1 | Weaver (4–5) | Griffin (8–7) | Frieri (23) | 43,515 | 45–49 | 2h 58m | W1 | | 95 | July 20 | Athletics | 2–0 | Wilson (10–6) | Straily (6–3) | Frieri (24) | 43,572 | 46–49 | 2h 31m | W2 | | 96 | July 21 | Athletics | 0–6 | Colón (13–3) | Williams (5–6) | | 37,441 | 46–50 | 2h 48m | L1 | | 97 | July 22 | Twins | 3–4 | Deduno (6–4) | Blanton (2–13) | Perkins (24) | 33,363 | 46–51 | 3h 31m | L2 | | 98 | July 23 | Twins | 3–10 (10) | Perkins (2–0) | Frieri (0–2) | | 39,177 | 46–52 | 3h 38m | L3 | | 99 | July 24 | Twins | 1–0 | Weaver (5–5) | Pelfrey (4–8) | Frieri (25) | 38,209 | 47–52 | 2h 43m | W1 | | 100 | July 25 | @ Athletics | 8–3 | Wilson (11–6) | Straily (6–4) | | 20,468 | 48–52 | 3h 13m | W2 | | 101 | July 26 | @ Athletics | 4–6 | Colón (14–3) | Williams (5–7) | Balfour (27) | 27,429 | 48–53 | 3h 12m | L1 | | 102 | July 27 | @ Athletics | 1–3 | Milone (9–8) | Downs (2–3) | Balfour (28) | 32,333 | 48–54 | 3h 03m | L2 | | 103 | July 28 | @ Athletics | 6–10 | Chavez (2–2) | Gutierrez (0–2) | | 25,877 | 48–55 | 3h 31m | L3 | | 104 | July 29 | @ Rangers | 3–4 | Frasor (1–2) | Frieri (0–3) | | 36,282 | 48–56 | 3h 04m | L4 | | 105 | July 30 | @ Rangers | 11–14 (10) | Nathan (2–1) | Stange (0–1) | | 36,931 | 48–57 | 4h 46m | L5 | | 106 | July 31 | @ Rangers | 1–2 | Nathan (3–1) | Kohn (1–1) | | 39,391 | 48–58 | 2h 30m | L6 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 107 | August 1 | Blue Jays | 8–2 | Richards (3–4) | Johnson (1–8) | | 37,179 | 49–58 | 2h 38m | W1 | | 108 | August 2 | Blue Jays | 7–5 | De La Rosa (5–1) | Delabar (5–2) | Frieri (26) | 38,884 | 50–58 | 3h 15m | W2 | | 109 | August 3 | Blue Jays | 7–3 | Weaver (6–5) | Rogers (3–6) | | 41,253 | 51–58 | 2h 35m | W3 | | 110 | August 4 | Blue Jays | 5–6 | Cecil (5–1) | Frieri (0–4) | Janssen (19) | 33,936 | 51–59 | 3h 05m | L1 | | 111 | August 5 | Rangers | 2–5 | Pérez (4–3) | Williams (5–8) | Nathan (33) | 34,040 | 51–60 | 3h 01m | L2 | | 112 | August 6 | Rangers | 3–8 | Darvish (11–5) | Jepsen (1–3) | Scheppers (1) | 34,233 | 51–61 | 3h 12m | L3 | | 113 | August 7 | Rangers | 3–10 | Ogando (5–3) | Hanson (4–3) | | 34,777 | 51–62 | 3h 51m | L4 | | 114 | August 9 | @ Indians | 5–2 | Weaver (7–5) | Kazmir (7–5) | De La Rosa (1) | 28,729 | 52–62 | 2h 50m | W1 | | 115 | August 10 | @ Indians | 7–2 | Wilson (12–6) | Jiménez (8–7) | | 32,733 | 53–62 | 3h 41m | W2 | | 116 | August 11 | @ Indians | 5–6 | Albers (3–1) | Gutiérrez (0–3) | Perez (18) | 23,433 | 53–63 | 3h 13m | L1 | | 117 | August 12 | @ Yankees | 1–2 | Kuroda (11–7) | Richards (3–5) | Robertson (1) | 37,146 | 53–64 | 2h 42m | L2 | | 118 | August 13 | @ Yankees | 7–14 | Sabathia (10–10) | Vargas (6–5) | | 35,013 | 53–65 | 3h 33m | L3 | | 119 | August 14 | @ Yankees | 3–11 | Nova (6–4) | Weaver (7–6) | | 38,379 | 53–66 | 2h 40m | L4 | | 120 | August 15 | @ Yankees | 8–4 | Wilson (13–6) | Hughes (4–12) | | 44,682 | 54–66 | 3h 49m | W1 | | 121 | August 16 | Astros | 2–8 | Peacock (2–4) | Williams (5–9) | | 39,074 | 54–67 | 3h 48m | L1 | | 122 | August 17 | Astros | 6–5 (10) | Frieri (1–14) | Fields (1–3) | | 40,246 | 55–67 | 3h 48m | W1 | | 123 | August 18 | Astros | 5–7 | Oberholtzer (3–1) | Gutiérrez (0–4) | Chapman (1) | 36,896 | 55–68 | 3h 22m | L1 | | 124 | August 19 | Indians | 2–5 | McAllister (6–7) | Weaver (7–7) | | 36,574 | 55–69 | 3h 03m | L2 | | 125 | August 20 | Indians | 1–4 (14) | Carrasco (1–4) | Blanton (2–14) | | 36,421 | 55–70 | 5h 17m | L3 | | 126 | August 21 | Indians | 1–3 | Masterson (14–9) | Williams (5–10) | Perez (20) | 35,810 | 55–71 | 2h 59m | L4 | | 127 | August 23 | @ Mariners | 2–0 | Richards (4–5) | Hernández (12–7) | Frieri (27) | 21,616 | 56–71 | 2h 45m | W1 | | 128 | August 24 | @ Mariners | 5–1 | Vargas (7–5) | Ramírez (4–1) | | 24,477 | 57–71 | 3h 18m | W2 | | 129 | August 25 | @ Mariners | 7–1 | Weaver (8–7) | Harang (5–11) | | 23,001 | 58–71 | 2h 50m | W3 | | 130 | August 27 | @ Rays | 6–5 | Frieri (2–4) | Rodney (5–4) | De La Rosa (2) | 12,939 | 59–71 | 3h 36m | W4 | | 131 | August 28 | @ Rays | 1–4 | Archer (8–5) | Richards (4–6) | Rodney (31) | 13,535 | 59–72 | 2h 47m | L1 | | 132 | August 29 | @ Rays | 2–0 | Vargas (8–5) | Odorizzi (0–1) | Frieri (28) | 15,741 | 60–72 | 3h 02m | W1 | | 133 | August 30 | @ Brewers | 5–0 | Weaver (9–7) | Peralta (8–14) | | 32,340 | 61–72 | 3h 16m | W2 | | 134 | August 31 | @ Brewers | 6–5 | De La Rosa (6–1) | Henderson (3–4) | Frieri (29) | 28,175 | 62–72 | 3h 19m | W3 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | Duration | Boxscore |
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| 135 | September 1 | @ Brewers | 5–3 | Wilson (14–6) | Wooten (3–1) | Frieri (30) | 29,733 | 63–72 | 3h 06m | W4 | | 136 | September 2 | Rays | 11–2 | Richards (5–6) | Archer (8–6) | | 37,557 | 64–72 | 3h 58m | W5 | | 137 | September 3 | Rays | 1–7 | Moore (15–3) | Vargas (8–6) | Hernández (1) | 34,332 | 64–73 | 3h 07m | L1 | | 138 | September 4 | Rays | 1–3 | Hellickson (11–8) | Weaver (9–8) | Rodney (32) | 34,025 | 64–74 | 2h 54m | L2 | | 139 | September 5 | Rays | 6–2 | Williams (6–10) | Price (8–7) | | 34,623 | 65–74 | 2h 49m | W1 | | 140 | September 6 | Rangers | 6–5 | Wilson (15–6) | Garza (9–4) | Frieri (31) | 39,591 | 66–74 | 2h 51m | W2 | | 141 | September 7 | Rangers | 8–3 | Richards (6–6) | Holland (9–8) | | 40,558 | 67–74 | 3h 10m | W3 | | 142 | September 8 | Rangers | 3–4 | Ogando (6–4) | Kohn (1–2) | Nathan (39) | 35,423 | 67–75 | 3h 31m | L1 | | 143 | September 9 | @ Twins | 3–6 | Fien (4–2) | Rasmus (0–1) | Perkins (33) | 21,826 | 67–76 | 3h 19m | L2 | | 144 | September 10 | @ Blue Jays | 12–6 | Williams (7–10) | Buehrle (11–8) | | 19,079 | 68–76 | 2h 43m | W1 | | 145 | September 11 | @ Blue Jays | 5–4 | Wilson (16–6) | Delabar (5–3) | Frieri (32) | 17,994 | 69–76 | 2h 43m | W2 | | 146 | September 12 | @ Blue Jays | 4–3 | Richards (7–6) | Happ (4–6) | Frieri (33) | 20,767 | 70–76 | 3h 10m | W3 | | 147 | September 13 | @ Astros | 7–9 | Keuchel (6–9) | Vargas (8–7) | Fields (5) | 19,742 | 70–77 | 3h 10m | L1 | | 148 | September 14 | @ Astros | 6–2 | Weaver (10–8) | Oberholtzer (4–3) | | 21,905 | 71–77 | 3h 11m | W1 | | 149 | September 15 | @ Astros | 2–1 | Williams (8–10) | Clemens (4–5) | Frieri (34) | 21,374 | 72–77 | 2h 57m | W2 | | 150 | September 16 | @ Athletics | 12–1 | Wilson (17–6) | Parker (11–7) | | 14,629 | 73–77 | 3h 09m | W3 | | 151 | September 17 | @ Athletics | 1–2 | Balfour (1–3) | Kohn (1–3) | | 18,771 | 73–78 | 3h 26m | L1 | | 152 | September 18 | @ Athletics | 5–4 (11) | Gutiérrez (1–4) | Chavez (2–4) | Frieri (35) | 74–78 | 20,260 | 3h 19m | W1 | | 153 | September 20 | Mariners | 3–2 (11) | Rasmus (1–1) | LaFromboise (0–1) | | 39,469 | 75–78 | 4h 10m | W2 | | 154 | September 21 | Mariners | 6–5 | Williams (9–10) | Saunders (11–16) | Frieri (36) | 41,001 | 76–78 | 3h 01m | W3 | | 155 | September 22 | Mariners | 2–3 | Pérez (3–3) | Wilson (17–7) | Farquhar (15) | 39,099 | 76–79 | 3h 22m | L1 | | 156 | September 23 | Athletics | 5–10 | Milone (12–9) | Richards (7–7) | | 41,147 | 76–80 | 3h 07m | L2 | | 157 | September 24 | Athletics | 3–0 | Vargas (9–7) | Griffin (14–10) | | 38,158 | 77–80 | 2h 17m | W1 | | 158 | September 25 | Athletics | 3–1 | Weaver (11–8) | Straily (10–8) | Frieri (37) | 36,226 | 78–80 | 2h 31m | W2 | | 159 | September 26 | @ Rangers | 5–6 | Nathan (6–2) | Kohn (1–4) | | 26,198 | 78–81 | 3h 22m | L1 | | 160 | September 27 | @ Rangers | 3–5 | Cotts (7–3) | Gutiérrez (1–5) | Nathan (42) | 37,355 | 78–82 | 3h 31m | L2 | | 161 | September 28 | @ Rangers | 4–7 | Soria (1–0) | Richards (7–8) | Nathan (43) | 38,635 | 78–83 | 3h 18m | L3 | | 162 | September 29 | @ Rangers | 2–6 | Cotts (8–3) | Vargas (9–8) | | 40,057 | 78–84 | 2h 57m | L4 |
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