5-hydroxyfuranocoumarin 5-O-methyltransferase

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5-hydroxyfuranocoumarin 5-O-methyltransferase
Identifiers
EC no. 2.1.1.69
CAS no. 101637-31-4&title= 67339-12-2, 101637-31-4
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5-hydroxyfuranocoumarin 5-O-methyltransferase (EC 2.1.1.69, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5.1-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction)
(2) S-adenosyl-L-methionine + bergaptol S-adenosyl-L-homocysteine + bergapten

The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin.

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<span class="mw-page-title-main">6-Hydroxymellein</span> Chemical compound

6-Hydroxymellein is a dihydroisocoumarin, a phenolic compound found in carrots. It has also been isolated in Aspergillus terreus and shows an inhibition of pollen development in Arabidopsis thaliana.

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Demethylspheroidene O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:demethylspheroidene O-methyltransferase. This enzyme catalyses the following chemical reaction

2-polyprenyl-6-hydroxyphenol methylase is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase. This enzyme catalyses the following chemical reaction

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2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:(2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl β-D-glucopyranoside 7-O-methyltransferase. This enzyme catalyses the following chemical reaction

Protein N-terminal methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction

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References

  1. ↑ Thompson HJ, Sharma SK, Brown SA (June 1978). "O-methyltransferases of furanocoumarin biosynthesis". Archives of Biochemistry and Biophysics. 188 (2): 272–81. doi:10.1016/s0003-9861(78)80009-5. PMID   28084.
  2. ↑ Sharma SK, Garrett JM, Brown SA (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Zeitschrift für Naturforschung C. 34C (5–6): 387–91. doi: 10.1515/znc-1979-5-611 . PMID   156999.
  3. ↑ Hauffe, K.D.; Hahlbrock, K.; Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Zeitschrift für Naturforschung C. 41: 228–239. doi: 10.1515/znc-1986-1-234 .
  4. ↑ Hehmann M, Lukacin R, Ekiert H, Matern U (March 2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". European Journal of Biochemistry. 271 (5): 932–40. doi:10.1111/j.1432-1033.2004.03995.x. PMID   15009205.
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