5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
Identifiers
EC no.	4.1.1.68
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4.1.1.68) catalyzes the chemical reaction

5-oxopent-3-ene-1,2,5-tricarboxylate ${\displaystyle \rightleftharpoons }$ 2-oxohept-3-enedioate + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming). Other names in common use include 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, and 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase. This enzyme participates in tyrosine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1I7O.

References

• Garrido-Peritierra A, Cooper RA (July 1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli". European Journal of Biochemistry. 117 (3): 581–4. doi: 10.1111/j.1432-1033.1981.tb06377.x . PMID   7026235.