APOBEC3D | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | APOBEC3D , A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609900; HomoloGene: 122788; GeneCards: APOBEC3D; OMA:APOBEC3D - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene. [3] [4]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [4]
Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. Dang Y, Wang X, Esselman WJ, Zheng YH. J Virol. 2006 Nov;80(21):10522-33. doi: 10.1128/JVI.01123-06. Epub 2006 Aug 18.