Acetyl-S-ACP:malonate ACP transferase

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Acetyl-S-ACP:malonate ACP transferase
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EC no. 2.3.1.187
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Acetyl-S-ACP:malonate ACP transferase (EC 2.3.1.187, acetyl-S-ACP:malonate ACP-SH transferase, acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase, MdcA, MadA, ACP transferase, malonate/acetyl-CoA transferase, malonate:ACP transferase, acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase) is an enzyme with systematic name acetyl-(acyl-carrier-protein):malonate S-(acyl-carrier-protein)transferase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

acetyl-[acyl-carrier protein] + malonate malonyl-[acyl-carrier protein] + acetate

This is the first step in the catalysis of malonate decarboxylation.

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Malonyl-CoA is a coenzyme A derivative of malonic acid.

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References

  1. Hilbi H, Dimroth P (1994). "Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase". Archives of Microbiology. 162 (1–2): 48–56. doi:10.1007/bf00264372. PMID   18251085.
  2. Hoenke S, Schmid M, Dimroth P (June 1997). "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli". European Journal of Biochemistry. 246 (2): 530–8. doi: 10.1111/j.1432-1033.1997.00530.x . PMID   9208947.
  3. Koo JH, Kim YS (December 1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". European Journal of Biochemistry. 266 (2): 683–90. doi: 10.1046/j.1432-1327.1999.00924.x . PMID   10561613.
  4. Chohnan S, Akagi K, Takamura Y (January 2003). "Functions of malonate decarboxylase subunits from Pseudomonas putida". Bioscience, Biotechnology, and Biochemistry. 67 (1): 214–7. doi: 10.1271/bbb.67.214 . PMID   12619701.
  5. Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi: 10.1046/j.1365-2958.1997.4611824.x . PMID   11902724.