Amit Singh (scientist)

Amit Singh
Born	(1976-03-18) March 18, 1976 (age 49) India
Alma mater	Indian Institute of Technology Roorkee University of Delhi South Campus University of Alabama at Birmingham
Known for	Mycobacterium tuberculosis pathogenesis
Awards	2021  Shanti Swarup Bhatnagar Prize for Science and Technology 2017/18  N-BIOS Prize
Scientific career
Fields	Microbiology
Institutions	International Centre for Genetic Engineering and Biotechnology Indian Institute of Science
Doctoral advisor	Anil Kumar Tyagi Adrie JC Steyn

Amit Singh (born 18 March 1976) is an Indian microbiologist in the Department of Microbiology & Cell Biology at the Indian Institute of Science. His primary research area is pathogenesis, with a focus on drug resistance mechanisms in both mycobacterium tuberculosis (TB) and human immunodeficiency viruses (HIV).

Biography

Amit Singh was born on 18 March 1976. ^[1] He obtained a bachelor's degree in Science from the University of Delhi and a master's degree in Biotechnology from Indian Institute of Technology Roorkee in 1998. ^[2] In 2004, he completed a PhD under the supervision of Anil Kumar Tyagi at the South Campus and subsequently moved to the US for postdoctoral training at the University of Alabama in Birmingham in the lab of Dr. Adrie JC Steyn. ^[3]

Upon his return to India in 2010, Singh was a Wellcome Trust-DBT Intermediate Fellow at the International Centre for Genetic Engineering and Biotechnology. In January 2014, he joined the Indian Institute of Science (IISc) in their department of microbiology and cell biology, where he is currently an associate professor. ^[4] He is the group leader at the Centre for Infectious Disease Research, ^[5] where researchers ^[6] investigate the mechanisms of chronic human infections with a focus on Mycobacterium tuberculosis and human immunodeficiency virus (HIV). ^{[7] [8]}

Awards

Singh has been a Welcome Trust-DBT Senior Fellow since 2016. ^{[9] [10]} He received the 2017/18 National Bioscience Award for Career Development from the Department of Biotechnology of the Government of India. ^[11]

In 2021, Singh was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology for his contributions to understanding host-pathogen interactions in Mycobacterium tuberculosis and HIV. ^[12] Singh was included in the Asian Scientist 100 in 2022.

Publications

Most cited articles at University of Alabama

• Singh, A; Crossman, DK; Mai, D; Guidry, L; Voskuil, MI; Renfrow, MB; Steyn, AJ (2009). "Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response". PLOS Pathog. 5 (8): e1000545. doi: 10.1371/journal.ppat.1000545 . PMC   2718811 . PMID   19680450. (Cited by 204 articles according to Google Scholar.)
• Singh, A; Guidry, L; Narasimhulu, KV; Mai, D; Trombley, J; Redding, KE; Giles, GI; Lancaster, JR Jr; Steyn, AJ (2007). "Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival". Proc Natl Acad Sci U S A. 104 (28): 11562–7. Bibcode:2007PNAS..10411562S. doi: 10.1073/pnas.0700490104 . PMC   1906726 . PMID   17609386. (Cited by 154 articles according to Google Scholar.)

Most cited articles at IISc

• Ashima Bhaskar, Manbeena Chawla, Mansi Mehta, Pankti Parikh, Pallavi Chandra, Devayani Bhave, Dhiraj Kumar, Kate S Carroll, Amit Singh. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. 2014. PLOS Pathogens. 10:1 e1003902. (Cited by 88 articles according to Google Scholar.)
• Rufai SB, Kumar P, Singh A, Prajapati S, Balooni V, Singh S. Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis. Journal of clinical microbiology. 2014 June; 52 (6): 1846–52. (Cited by 76 articles according to Google Scholar.)
• Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D. Adrie JC Steyn and Amit Singh. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Molecular microbiology. 2012 September; 85 (6): 1148–65. (Cited by 56 articles according to Google Scholar.)

References

1. "Scientist Amit Singh". Hindi Info World. 26 November 2021.
2. "Centre for Infectious Disease Research (CIDR)". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
3. "India Alliance - Advancing Discovery & Innovation to Improve Health". www.indiaalliance.org. Retrieved 13 March 2025.
4. "MCB". mcbl.iisc.ac.in. 11 January 2019. Archived from the original on 13 January 2019. Retrieved 11 January 2019.
5. "Centre for Infectious Disease Research (CIDR) Group Leader". cidr.iisc.ernet.in. 11 January 2019. Archived from the original on 12 January 2019. Retrieved 11 January 2019.
6. "Centre for Infectious Disease Research (CIDR) fellows". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 3 July 2018. Retrieved 11 January 2019.
7. "Welcome to lab web page of Dr. Amit Singh". cidr.iisc.ac.in. 11 January 2019. Archived from the original on 4 October 2018. Retrieved 11 January 2019.
8. Bhaskar, Ashima; Chawla, Manbeena; Mehta, Mansi; Parikh, Pankti; Chandra, Pallavi; Bhave, Devayani; Kumar, Dhiraj; Carroll, Kate; Singh, Amit (2014). "Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection". PLOS Pathogens. 10 (1): e1003902. doi: 10.1371/journal.ppat.1003902 . PMC   3907381 . PMID   24497832.
9. "India Alliance - About Fellow". www.indiaalliance.org. 11 January 2019. Retrieved 11 January 2019.
10. "Amit Singh Group, Indian Institute of Science, Bangalore -- Publication" . Retrieved 8 May 2019.
11. "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Archived from the original (PDF) on 4 March 2018. Retrieved 20 November 2017.
12. "Shanti Swarup Bhatnagar Prize (SSB) for Science and Technology 2021" (PDF). sbprize.gov.in. Council of Scientific and Industrial Research . Retrieved 26 September 2021.

Further reading

• Prasad, R. (29 September 2018). "IISc team finds new approaches to kill TB bacteria". The Hindu. Retrieved 11 January 2019.
• "How do TB bacteria develop resistance to common antibiotics? A new study at IISc attempts to answer this". Research Matters. 6 July 2017. Retrieved 11 January 2019.

External links

• Official home page at IISc