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The 2015 version of this article was updated by an external expert under a dual publication model. The corresponding academic peer reviewed article was published in Gene and can be cited as: Erica A Golemis (1 October 2015). "Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members". Gene . 570 (1): 25–35. doi:10.1016/J.GENE.2015.06.062. PMC 4519417 . PMID 26119091. |
Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.
Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.
Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.
SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.
Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.
Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.
CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and cytoskeletal formation. It is mainly expressed in heart, skeletal muscle, liver, adipose tissue, and macrophages; in striated muscle tissue, it is localized to costamere structures.
FYN binding protein (FYB-120/130), also known as FYB, ADAP, and SLAP-130 is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.
CD84 is a human protein encoded by the CD84 gene.
Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.
SH2 domain containing 3C, also known as SH2D3C, is a protein that in humans is encoded by the SH2D3C gene.
Tensin-1 is a protein that in humans is encoded by the TNS1 gene.
Embryonal fyn-associated substrate is a protein that in humans is encoded by the EFS gene. It is also known as CASS3.
Erica A. Golemis is an American oncologist. She is the William Wikoff Smith Chair in Cancer Research at Fox Chase Cancer Center, as well as deputy chief science officer and co-leader of the molecular therapeutics program.