| CCDC184 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CCDC184 , C12orf68, coiled-coil domain containing 184 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2146066 HomoloGene: 18612 GeneCards: CCDC184 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Coiled-coil domain-containing 184 (CCDC184) is a protein which, in humans, is encoded by the CCDC184 gene
Alias for the CCDC184 gene is C12orf68, chromosome 12 open reading frame 68. [5] CCDC184 mRNA sequence, which is 2283 nucleotides in length, and is composed of 1 exon.
Human CCDC184 is primarily expressed in the components of the brain, such as hypothalamus, pons, pituitary gland. [6] The gene's expression is enhanced and/or over-expressed in the brain tissue expression. [7] Tissue expression cluster predicted Pituitary gland - Hormone signaling [8]
CCDC184 Protein is 194 amino acid and contains a domain of unknown function, DUF4677, which spans for 193 amino acid long . CCDC184 protein has a theoretical molecular weight of 20,484 [9] dalton and an isoelectric point of 4.04. [10] This indicates the acidic nature of the sequence. The molecular function of the protein is protein binding [11]
CCDC184 contains various predicted post-translational modification domains, including phosphorylation, SUMOylation, Glutaredoxin, Myristoylation, Glutamic acid-rich region, and acetylation. The phosphosphorylation sites include S23, T24, and Y36. [12]
| Modification | Amino acid Region |
|---|---|
| Phosphorylation | 76, 113, 155, 120, 122, 162 |
| Myristoylation | 103-108, 109-114, 124-129, 166-172 |
| Glutaredoxin domain | 1-62 |
| Glutamic acid-rich region | 136-146 |
| SUMOylation | 102-106, 183-187 |
P = Phosphorylation site, Sumo: Sumo interacting regions, DUF4677: domain of unknown function
The human CCDC184 protein is predicted to be localized in the cytoplasm [13]
AlphaFold figure indicates 3D model of CCDC184. The colors indicate the charged regions of the structure
The annotated elements shown in the conceptual translation for human CCDC184 protein is post-translational modifications, alpha helices, SUMOylation, Lysine acetylation, domain of unknown function.
CCDC184 is found only in mammals. 183 organisms that have orthologs with the human gene CCDC184.
Orthologs for CCDC184 are only found in mammals. The most distantly related species to human CCDC184 with a date of divergence of 160 MYA is the opossum. The Tasmanian devil also has a date of divergence of 160 MYA. The table indicates a various selection portion of the mammals' list.
| Taxonomic Order | Genus and Species | Common Name | Accession Number | Sequence Length(aa) | Date of Divergence(MYA) | % Identity to the human protein | % Similarity to the human protein |
|---|---|---|---|---|---|---|---|
| Primate | Homo sapiens | Human | NP_001013657.3 | 194 | 0 | 100 | 100 |
| Primate | Carlito syrichta | Philippine tarsier | XP_008067440.1 | 194 | 69 | 93.3 | 97.4 |
| Scandentina | Tupaia chinensis | Chinese tree shrew | XP_006163517.1 | 85 | 85 | 89.7 | 93.8 |
| Rodentia | Mus musculus | Mouse | NP_808384.2 | 191 | 87 | 90.2 | 82.8 |
| Carnivora | Lontra canadensis | River otter | XP_032732811.1 | 193 | 94 | 93.8 | 96.9 |
| Carnivora | Ursus americanus | American black bear | XP_045656783.1 | 195 | 94 | 94.9 | 96.9 |
| Cetacea | Neophocaena asiaeorientalis asiaeorientalis | Finless porpoise | XP_024592814.1 | 195 | 94 | 92.8 | 95.9 |
| Cetacea | Delphinapterus leucas | Beluga whale | XP_022428046.1 | 195 | 94 | 93.3 | 96.4 |
| Artiodactyla | Camelus ferus | Bactrian camel | XP_006196007.2 | 195 | 94 | 94.9 | 97.4 |
| Artiodactyla | Sus scrofa | Wild boar | XP_020948280.1 | 195 | 94 | 92.8 | 95.4 |
| Chiroptera | Desmodus rotundus | Vampire bat | XP_024431436.1 | 195 | 94 | 90.3 | 93.8 |
| Pilosa | Choloepus didactylus | Two-toed sloth | XP_037701005.1 | 196 | 99 | 88.8 | 92.9 |
| Proboscidea | Elephas maximus indicus | Indian elephant | XP_049738921.1 | 197 | 99 | 89.3 | 94.9 |
| Cingulata | Dasypus novemcinctus | Nine-banded armadillo | XP_004470453.1 | 192 | 99 | 90.2 | 93.3 |
| Marsupial | Gracilinanus agilis | Agile gracile opossum | XP_044534020.1 | 186 | 160 | 72.8 | 80 |
| Marsupial | Sarcophilus harrisii | Tasmanian devil | XP_031793886.1 | 187 | 160 | 69.2 | 77.6 |
The figure indicates a chart showing the divergence of CCDC184, Cytochrome C and Fibrogen Alpha.
Predicted interactions for the CCDC184 gene were seen and the interactions revolved around enabling protein binding activity. Expressions of CCDC184 were connected to studies done on tissue samples for breast cancer somatic mutations [14]
SOGA2, also known as Suppressor of glucose autophagy associated 2 or CCDC165, is a protein that in humans is encoded by the SOGA2 gene. SOGA2 has two human paralogs, SOGA1 and SOGA3. In humans, the gene coding sequence is 151,349 base pairs long, with an mRNA of 6092 base pairs, and a protein sequence of 1586 amino acids. The SOGA2 gene is conserved in gorilla, baboon, galago, rat, mouse, cat, and more. There is distant conservation seen in organisms such as zebra finches and anoles. SOGA2 is ubiquitously expressed in humans, with especially high expression in brain, colon, pituitary gland, small intestine, spinal cord, testis and fetal brain.
Coiled Coil Domain Containing protein 42B, also known as CCDC42B, is a protein encoded by the protein-coding gene CCDC42B.
Coiled-coil domain 47 (CCDC47) is a gene located on human chromosome 17, specifically locus 17q23.3 which encodes for the protein CCDC47. The gene has several aliases including GK001 and MSTP041. The protein itself contains coiled-coil domains, the SEEEED superfamily, a domain of unknown function (DUF1682) and a transmembrane domain. The function of the protein is unknown, but it has been proposed that CCDC47 is involved in calcium ion homeostasis and the endoplasmic reticulum overload response.
Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One notable feature of this protein is the presence of proline residues on one of its predicted transmembrane domains., which is a determinant of the intramitochondrial sorting of inner membrane proteins.
Vexin is a protein encoded by VXN gene. VXN is found to be highly expressed in regions of the brain and spinal cord.
Glutamate rich protein 5 is a protein in humans encoded by the ERICH5 gene, also known as chromosome 8 open reading frame 47 (C8orf47).
C14orf93 is a protein that is encoded in humans by the C14orf93 gene. It is a globular protein with a conserved C-terminus that is localized to the nucleus. While expressed relatively highly in all tissues except nervous tissue, it is expressed particularly highly in T cells and other immune tissues.
C15orf39 is a protein that in humans is encoded by the Chromosome 15 open reading frame 15 (C15orf39) gene.
Testis expressed 55 (TEX55) is a human protein that is encoded by the C3orf30 gene located on the forward strand of human chromosome three, open reading frame 30 (3q13.32). TEX55 is also known as Testis-specific conserved, cAMP-dependent type II PK anchoring protein (TSCPA), and uncharacterized protein C3orf30.
Chromosome 1 open reading frame (C1orf167) is a protein which in humans is encoded by the C1orf167 gene. The NCBI accession number is NP_001010881. The protein is 1468 amino acids in length with a molecular weight of 162.42 kDa. The mRNA sequence was found to be 4689 base pairs in length.
Coiled-coil domain containing 121 (CCDC121) is a protein encoded by the CCDC121 gene in humans. CCDC121 is located on the minus strand of chromosome 2 and encodes three protein isoforms. All isoforms of CCDC121 contain a domain of unknown function referred to as DUF4515 or pfam14988.
Family with Sequence Similarity 155 Member B is a protein in humans that is encoded by the FAM155B gene. It belongs to a family of proteins whose function is not yet well understood by the scientific community. It is a transmembrane protein that is highly expressed in the heart, thyroid, and brain.
Family with sequence 98, member C or FAM98C is a gene that encodes for FAM98C has two aliases FLJ44669 and hypothetical protein LOC147965. FAM98C has two paralogs in humans FAM98A and FAM98B. FAM98C can be characterized for being a Leucine-rich protein. The function of FAM98C is still not defined. FAM98C has orthologs in mammals, reptiles, and amphibians and has a distant orhtologs in Rhinatrema bivittatum and Nanorana parkeri.
Chromosome 5 open reading frame forty-nine, also known as C5orf49, is a protein that in humans is encoded by the C5orf49 gene. Aliases for C5orf49 include Chromosome 5 Open Reading Frame 49, Uncharacterized Protein C5orf49 and LOC134121. C5orf49 is predicted to localize to the cilia and have ciliary functions.
C11orf98 is a protein-encoding gene on chromosome 11 in humans of unknown function. It is otherwise known as c11orf48. The gene spans the chromosomal locus from 62,662,817-62,665,210. There are 4 exons. It spans across 2,394 base pairs of DNA and produces an mRNA that is 646 base pairs long.
C4orf19 is a protein which in humans is encoded by the C4orf19 gene.
IGSF6 is a protein that in humans is encoded by the IGSF6 gene.
Chromosome 13 Open Reading Frame 46 is a protein which in humans is encoded by the C13orf46 gene. In humans, C13orf46 is ubiquitously expressed at low levels in tissues, including the lungs, stomach, prostate, spleen, and thymus. This gene encodes eight alternatively spliced mRNA transcript, which produce five different protein isoforms.
Secernin-3 (SCRN3) is a protein that is encoded by the human SCRN3 gene. SCRN3 belongs to the peptidase C69 family and the secernin subfamily. As a part of this family, the protein is predicted to enable cysteine-type exopeptidase activity and dipeptidase activity, as well as be involved in proteolysis. It is ubiquitously expressed in the brain, thyroid, and 25 other tissues. Additionally, SCRN3 is conserved in a variety of species, including mammals, birds, fish, amphibians, and invertebrates. SCRN3 is predicted to be an integral component of the cytoplasm.
FAM131A is a protein that is encoded by the FAM131A gene in humans. Aliases for FAM131A include C3orf40, FLAT715, and PRO1378.
