Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as secondary metabolites in several plants such as foxglove plants and milkweed plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment.
Abrus precatorius, commonly known as jequirity bean or rosary pea, is a herbaceous flowering plant in the bean family Fabaceae. It is a slender, perennial climber with long, pinnate-leafleted leaves that twines around trees, shrubs, and hedges.
Cerberin is a type of cardiac glycoside, found in the seeds of the dicotyledonous angiosperm genus Cerbera; including the suicide tree and the sea mango. As a cardiac glycoside, cerberin disrupts the function of the heart by blocking its sodium and potassium ATPase. Cerberin can be used as a treatment for heart failure and arrhythmia.
Cerbera is a genus of evergreen trees or shrubs, native to tropical Asia, Australia, Madagascar, and various islands in the Indian and Pacific Oceans.
Tilia americana is a species of tree in the family Malvaceae, native to eastern North America, from southeast Manitoba east to New Brunswick, southwest to northeast Oklahoma, southeast to South Carolina, and west along the Niobrara River to Cherry County, Nebraska. It is the sole representative of its genus in the Western Hemisphere, assuming T. caroliniana is treated as a subspecies or local ecotype of T. americana. Common names include American basswood and American linden.
Lactucopicrin (Intybin) is a bitter substance that has a sedative and analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone, and is a component of lactucarium, derived from the plant Lactuca virosa, as well as being found in some related plants such as Cichorium intybus. It is also found in dandelion coffee.
Mesembryanthemum tortuosum is a succulent plant in the family Aizoaceae native to the Cape Provinces of South Africa. It is known as the Namaqua skeletonfig, kanna, channa, kougoed —which literally means, 'chew(able) things' or 'something to chew'.
Impatiens capensis, the orange jewelweed, common jewelweed, spotted jewelweed, jewelweed, spotted touch-me-not, or orange balsam, is an annual plant in the family Balsaminaceae that is native to North America. It is common in bottomland soils, ditches, and along creeks, often growing side by side with its less common relative, yellow jewelweed.
Mesembrine is an alkaloid primarily derived from the plant Sceletium tortuosum, commonly known as kanna. This compound is noted for its psychoactive properties, particularly as a serotonin reuptake inhibitor, which contributes to its potential use in treating mood disorders and anxiety. Mesembrine has garnered interest in both traditional medicine and modern pharmacology, where it is explored for its effects on enhancing mood and cognitive function. The plant itself has a long history of use by indigenous peoples in southern Africa, who utilized it for its mood-enhancing and stress-relieving effects, often consuming it in various forms such as teas or chews.
Kaempferia galanga, commonly known as kencur, aromatic ginger, sand ginger, cutcherry, is a monocotyledonous plant in the ginger family, and one of four plants called galangal. It is found primarily in open areas in Indonesia, southern China, Taiwan, Cambodia, and India, but is also widely cultivated throughout Southeast Asia.
Cerbera manghas, commonly known as the sea mango, tangena or bintaro is a small evergreen coastal tree growing up to 12 metres (39 ft) tall. It is native to coastal areas in Africa, Asia, Australasia, and the Pacific islands. It is classified as one of the three species in the genus Cerbera that constitute mangroves.
Aporosa cardiosperma is a species of plant in the family Phyllanthaceae. It is endemic to South-West India and Sri Lanka. The fruit has two seeds covered with sour gelatinous pulp that is fed on by birds which disperse the seeds. In the Western Ghats of India, the thin stems of the tree are often galled by Cecidomyiidae. An echinate gall formation has also been noted in Kerala.
Cissus quadrangularis is a perennial plant of the grape family. It is commonly known as veldt grape, winged treebine or adamant creeper. The species is native to tropical Asia, the Arabian Peninsula and much of Africa.
Erythrina velutina is a species of leguminous tree. It is indigenous to Brazil, Peru, Ecuador, Colombia, Venezuela, and Hispaniola and has been introduced to much of the Caribbean, Uganda, and Sri Lanka. It also occurs on the Galápagos Islands, but whether it is indigenous or introduced there is unclear. In Brazil, it occurs on plains and near rivers in the arid parts of the northeast of the country and is commonly known as "mulungu". Erythrina velutina grows as a large tree to around 10 m (30 ft) high and has short spines on the stem. It is perennial.
The tangena ordeal was a form of trial by ordeal practiced in Madagascar to determine the guilt or innocence of an accused party. The trial utilized seeds of the tree species Cerbera manghas, which produces seeds that contain highly toxic cardiac glycosides including cerberin and tanghinin.
Pittosporum angustifolium is a shrub or small tree growing throughout inland Australia. Common names include weeping pittosporum, butterbush, cattle bush, native apricot, apricot tree, gumbi gumbi, cumby cumby, meemeei, poison berry bush, and berrigan.
Atractyloside (ATR) is a natural, toxic glycoside present in numerous plant species worldwide in the daisy family including Atractylis gummifera and Callilepis laureola, and it's used for a variety of therapeutic, religious, and toxic purposes. Exposure to ATR via ingestion or physical contact is toxic and can be fatal for both humans and animals, especially by kidney and liver failure. ATR acts as an effective ADP/ATP translocase inhibitor which eventually halts ADP and ATP exchange and the cell dies due to lack of energy. Historically, atractyloside poisoning has been challenging to verify and quantify toxicologically, though recent literature has described such methods within acceptable standards of forensic science.
Ficus amplissima, also known as the Indian bat tree, Indian bat fig, Pimpri, Pipri (Piparee), Pipali or Bilibasari mara is a tree species of flowering plants that belongs to Moraceae, the fig or mulberry family. It is native to Central and southern Peninsular India, Sri Lanka and Maldives, having a significant distribution throughout Western Ghats of India. It is most commonly planted to provide shade in coffee plantations due to its dense and wide foliage. The ripened figs attract many birds, especially during the spring.
Cerbera inflata, commonly known as the cassowary plum, grey milkwood, Joojooga, or rubber tree, is a plant in the family Apocynaceae endemic to northeast Queensland, specifically the Atherton Tablelands and adjacent areas.
Capparis sepiaria, also commonly called hedge caper or wild caper bush, is a shrub that has a pantropical distribution, especially in dry deciduous forests, foothills and scrub jungles.
