Cerbera odollam

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Cerbera odollam
Cerbera odollam 08718.jpg
Cerbera odollam, or the "pong-pong" tree
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Gentianales
Family: Apocynaceae
Genus: Cerbera
Species:
C. odollam
Binomial name
Cerbera odollam
Synonyms

Cerbera dilatata Markgr.

Cerbera odollam is a tree species in the family Apocynaceae commonly known as the suicide tree or pong-pong. [1] It bears a fruit known as othalanga whose seeds yield a potent poison called cerberin that has been used for trials by ordeal, [2] suicide, and poisonings. [3]

Contents

It is native to South and Southeast Asia, Pacific Islands, and Queensland, Australia, [4] growing preferentially along sandy coasts, riverbanks, and by mangrove swamps. It is also grown in tropical areas such as Hawaii as an ornamental. [5]

Description

Diagram of different parts of the Cerbera odollam plant. Cerbera manghas - Kohler-s Medizinal-Pflanzen-175.jpg
Diagram of different parts of the Cerbera odollam plant.

Cerbera odollam bears a close resemblance to oleander, another highly toxic plant from the same family. It grows to approximately 10–12 meters in height. Its leaves are glossy and it has white flowers with yellow throats. [6] The plant as a whole yields a milky, white latex.[ citation needed ]

Its fruit, about 5–10cm in length, starts green and becomes red as it matures. [7] It has a green fibrous shell enclosing an ovoid kernel measuring approximately 2 cm × 1.5 cm and containing two extremely poisonous seeds. On exposure to air, the white kernel turns violet, then dark grey, and ultimately brown, or black. [8]

History

Common names

Cerbera odollam is known by a number of vernacular names, depending on the region. These include othalam (ഒതളം) in the Malayalam language used in Kerala, India; kattu arali (காட்டரளி) in the adjacent state of Tamil Nadu; dabur (ডাবুর) in Bengali; famentana, kisopo, samanta or tangena in Madagascar; and pong-pong, buta-buta, bintaro or nyan in Southeast Asia. [9]

Use in trials by ordeal

The poisonous kernel of the Cerbera odollam fruit was used in trials by ordeal like the tangena throughout the regions where it grew. In Madagascar in the 18th and 19th centuries, over 3000 people died per year from consuming Cerbera odollam seeds in a trial by ordeal. These trials were intended to determine whether the subject was guilty of a crime, often witchcraft. [10] In these trials, a dosage of the seed was administered. If the subject lived, they were considered innocent of whatever crime they were accused. If they died, they were considered guilty. These trials relied on the belief that some underlying spirit would distinguish between innocence and guilt. [11]

Trials by ordeal using cerberin were extremely common. In the mid-1800s, leaders attempted to regulate trials by ordeal in Madagascar. For minor crimes, dogs or chickens were used as a substitute for humans. However, it wasn't until the early 1900s that this practice stopped. [12]

Use for suicide

Cerbera odollam was also frequently used for suicide and continues to be used for this purpose in the modern day. For instance, a 2004 study found that it was responsible for about one suicide death per week between 1989 and 1999 in Kerala, India. [13] To commit suicide, people would remove the kernels from the seed and combine it with jaggery to eat. Death would occur quickly, about 3-6 hours after ingestion. [14]

Toxicity

Cerberin, the poisonous compound in the kernels of Cerbera odollam, is a cardiac glycoside and, as such, blocks the heart's sodium and potassium ATPase. [15] One kernel contains a fatal dose of the toxin. [16]

Symptoms

Cerbera odollam Pong pong tree.jpg
Cerbera odollam

Electrocardiographic abnormalities are common, the most common being sinus bradycardia. [17] Around half of the patients develop thrombocytopenia. Temporary cardiac pacing has been used in the management, apart from other supportive measures. [18]

Other common symptoms of cerberin poisoning include a burning sensation in the mouth, vomiting, retching, nausea, irregular respiration, headache, coma, and death. [19] Some cases are asymptomatic. [20]

Use as a poison

Cerbera odollam is commonly used for poisonings as well as suicides. Its bitter flavor can easily be masked by spicy food, allowing victims to ingest it without noticing. [21] In Kerala, C. odollam is responsible for about 50% of plant poisoning cases and 10% of all poisonings. [22]

The fatalities from poisonings, particularly from C. odollam, are underestimated due to the lack of testing in most cases. [23] Poisonings outside the tree's natural range are considered rare. [24]

Modern uses

Flowers of Cerbera odollam Cerbera odollam.jpg
Flowers of Cerbera odollam

The seeds of C. odollam are used as biopesticides, insect repellants, and rat poisons [25] due to its toxicity to these animals.

Investigations have also been made into the feasibility of using the seeds as a feedstock in the production of biodiesel. Oil can be extracted from the seeds and transesterified into fatty acid methyl esters. This is a good alternative to other plants commonly used for biodiesels because unlike these plants, it grows on typically non-arable land and therefore does not compete with food crops. [26]

See also

Related Research Articles

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<span class="mw-page-title-main">Atractyloside</span> Chemical compound

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References

  1. Wermuth, Mary E.; Vohra, Rais; Bowman, Nena; Furbee, R. Brent; Rusyniak, Daniel E. (October 2018). "Cardiac Toxicity from Intentional Ingestion of Pong-Pong Seeds (Cerbera Odollam)". The Journal of Emergency Medicine. 55 (4): 507–511. doi:10.1016/j.jemermed.2018.05.021. ISSN   0736-4679. PMID   29941374 . Retrieved 14 October 2023.
  2. Kaplan, Sarah (25 October 2021). "The brutal harvest of India's 'suicide tree'". Washington Post. Retrieved 14 October 2023.
  3. "'Suicide tree' toxin is 'perfect' murder weapon". New Scientist. Retrieved 5 May 2024.
  4. "Cerbera odollam Gaertn". Plants of the World Online . Royal Botanic Gardens, Kew . Retrieved 9 October 2022.
  5. "National Tropical Botanical Garden | Cerbera odollam - Plant Detail - Tropical Plants Database". National Tropical Botanical Garden. Retrieved 5 May 2024.
  6. "NParks | Cerbera odollam". www.nparks.gov.sg. Retrieved 5 May 2024.
  7. "National Tropical Botanical Garden | Cerbera odollam - Plant Detail - Tropical Plants Database". National Tropical Botanical Garden. Retrieved 5 May 2024.
  8. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  9. Gaillard Y, Krishnamoorthy A, Bevalot F., 2004, "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India," J. Ethnopharmacol.95(2-3):123-126.
  10. Kaplan, Sarah (25 October 2021). "The brutal harvest of India's 'suicide tree'". Washington Post. Retrieved 5 May 2024.
  11. Robb, George L. (1957). "The Ordeal Poisons of Madagascar and Africa". Botanical Museum Leaflets, Harvard University. 17 (10): 265–316. doi:10.5962/p.168507. ISSN   0006-8098. JSTOR   41762174 . Retrieved 5 May 2024.
  12. Robb, George L. (1957). "The Ordeal Poisons of Madagascar and Africa". Botanical Museum Leaflets, Harvard University. 17 (10): 265–316. doi:10.5962/p.168507. ISSN   0006-8098. JSTOR   41762174 . Retrieved 5 May 2024.
  13. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  14. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  15. Botelho, Ana Flávia M.; Pierezan, Felipe; Soto-Blanco, Benito; Melo, Marília Martins (February 2019). "A review of cardiac glycosides: Structure, toxicokinetics, clinical signs, diagnosis and antineoplastic potential". Toxicon. 158: 63–68. doi: 10.1016/j.toxicon.2018.11.429 . PMID   30529380.
  16. Menezes, Ritesh G.; Usman, Muhammad Shariq; Hussain, Syed Ather; Madadin, Mohammed; Siddiqi, Tariq Jamal; Fatima, Huda; Ram, Pradhum; Pasha, Syed Bilal; Senthilkumaran, S.; Fatima, Tooba Qadir; Luis, Sushil Allen (August 2018). "Cerbera Odollam Toxicity: A Review". Journal of Forensic and Legal Medicine. 58: 113–116. doi:10.1016/j.jflm.2018.05.007. ISSN   1878-7487. PMID   29778924. S2CID   29155448.
  17. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  18. Menon, M Suraj (2016). "Clinical profile and management of poisoning with suicide tree: An observational study". Heart Views. 17 (4): 136–139. doi: 10.4103/1995-705X.201783 . PMC   5363088 . PMID   28400936.
  19. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  20. Menon, MSuraj; Kumar, Prasantha; Jayachandran, Ci (2016). "Clinical profile and management of poisoning with suicide tree: An observational study". Heart Views. 17 (4): 136–139. doi: 10.4103/1995-705X.201783 . PMC   5363088 . PMID   28400936.
  21. "'Suicide tree' toxin is 'perfect' murder weapon". New Scientist. Retrieved 5 May 2024.
  22. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  23. Gaillard, Yvan; Krishnamoorthy, Ananthasankaran; Bevalot, Fabien (December 2004). "Cerbera odollam: a 'suicide tree' and cause of death in the state of Kerala, India". Journal of Ethnopharmacology. 95 (2–3): 123–126. doi:10.1016/j.jep.2004.08.004. PMID   15507323.
  24. Wermuth, Mary E.; Vohra, Rais; Bowman, Nena; Furbee, R. Brent; Rusyniak, Daniel E. (October 2018). "Cardiac Toxicity from Intentional Ingestion of Pong-Pong Seeds (Cerbera Odollam)". The Journal of Emergency Medicine. 55 (4): 507–511. doi:10.1016/j.jemermed.2018.05.021. PMID   29941374.
  25. "NParks | Cerbera odollam". www.nparks.gov.sg. Retrieved 5 May 2024.
  26. Kansedo, Jibrail; Lee, Keat Teong; Bhatia, Subhash (June 2009). "Cerbera odollam (sea mango) oil as a promising non-edible feedstock for biodiesel production". Fuel. 88 (6): 1148–1150. Bibcode:2009Fuel...88.1148K. doi:10.1016/j.fuel.2008.12.004.