Chewing tobacco

Last updated
American Red Man loose leaf chewing tobacco and Danish pelletized Oliver Twist dip Tuggtobak.jpg
American Red Man loose leaf chewing tobacco and Danish pelletized Oliver Twist dip

Chewing tobacco is a type of smokeless tobacco product that is placed between the cheek and lower gum to draw out its flavor. It consists of coarsely chopped aged tobacco that is flavored and often sweetened; it is not ground fine like dipping tobacco. Unwanted juices are spat after use.

Contents

Chewing tobacco is a source of nicotine and therefore highly addictive. [1] Quitting chewing tobacco use is as challenging as smoking cessation. [2]

Using chewing tobacco can cause various harmful effects such as dental disease, oral cancer, oesophagus cancer, and pancreas cancer, coronary heart disease, as well as negative reproductive effects including stillbirth, premature birth and low birth weight. [3] [4] Chewing tobacco poses a lower health risk than traditional combusted products. [5] However it is not a healthy alternative to cigarette smoking. [6] The level of risk varies between different types of products and producing regions. [7] [5] There is no safe level of chewing tobacco use. [6] Globally it contributes to 650,000 deaths each year. [8]

Types

Chewing tobacco is sold in several different varieties. Chewing tobacco may be left as loose leaf or compressed into a small rectangular "plug". Nearly all modern chewing tobaccos are produced by a process of leaf curing, cutting, fermentation, and processing, which may include sweetening and flavoring. Historically, many American chewing-tobacco brands popular during the American Civil War era were made with cigar clippings.

Loose-leaf

Loose-leaf chewing tobacco is the most widely available and most frequently used type of chewing tobacco. It consists of shredded tobacco leaf, usually sweetened and sometimes flavored, and often sold in a sealed pouch typically weighing 3 oz. Loose-leaf chewing tobacco has a sticky texture due to the sweeteners added. Common loose-leaf chewing tobacco brands include America's Best Chew, Levi Garrett, Beech-Nut, and Stoker's.

Plug

Red Man Plug chewing tobacco Plug Chewing Tobacco.JPG
Red Man Plug chewing tobacco

Plug chewing tobacco is tobacco leaves pressed into a square, brick-like mass called a plug. From this, pieces are bitten off or cut from the plug and then chewed. Plug tobacco is declining in popularity, thus less readily available than loose-leaf chewing tobacco. Historically, plug tobacco could be either smoked in a pipe or chewed,[ citation needed ] but today, these are two distinct products.

Twist

Twist chewing tobacco consists of leaves twisted together into a rope-like mass. Unlike most loose-leaf tobaccos, twist chewing tobacco is usually not sweetened. Pieces of twist are either bitten off or cut, and then chewed. Twist chewing tobacco is not widely available and is mostly found in Appalachia. Historically, twists could also be smoked in a pipe, or ground up into nasal snuff. [9]

Health effects

Even though it is less dangerous than smoking, chewing tobacco is addictive, represents a major health risk, has no safe level use and is not a safe substitute for smoking. [10] [11] [12] [13] Globally it contributes to 650 000 deaths each year with a significant proportion of them in Southeast Asia. [14] [15]

Using chewing tobacco can cause a number of adverse health effects such as dental disease, oral cancer, oesophagus cancer, and pancreatic cancer, cardiovascular disease, asthma, and deformities in the female reproductive system. [16] It also raises the risk of fatal coronary artery disease, fatal stroke and non-fatal ischaemic heart disease [17] [18]

Quitting chewing tobacco use is as challenging as smoking cessation. [19] There is no scientific evidence that using chewing tobacco can help a person quit smoking. [20] [21]

Cancer

Chewing tobacco is a cause of oral cancer, oesophagus cancer, and pancreas cancer. [22] Increased risk of oral cancer caused by chewing tobacco is present in countries such as the United States but particularly prevalent in Southeast Asian countries where the use of smokeless tobacco is common. [23] [24]

All tobacco products, including chewing, contain cancer-causing chemicals. [25] [26] These carcinogenic compounds occurring in chewing tobacco vary widely, and depend upon the kind of product and how it was manufactured. [27] There are 28 known cancer-causing substances in chewing tobacco products. [27]

Cardiovascular disease

Using chewing tobacco increases the risk of fatal coronary heart disease and stroke. [28] [29] In 2010 more than 200 000 people died from coronary heart disease due to smokeless tobacco use. [30] Use of chewing tobacco also seems to greatly raise the risk of non-fatal ischaemic heart disease among users in Asia, although not in Europe. [28]

Effects during pregnancy

Chewing tobacco can cause adverse reproductive effects including stillbirth, premature birth, low birth weight. [28] [31] Nicotine in chewing tobacco products that are used during pregnancy can affect how a baby's brain develops before birth. [31]

Chewing tobacco and baseball

When the rules of baseball were first written in 1845, the carcinogenic potential of chewing tobacco was unknown. At that time, it was commonly used by players and coaches alike. [32] Smokeless tobacco use became rampant by players by the early 1900s. The use of chewing tobacco in baseball steadily increased until the mid-20th century, when cigarettes became popular and took the place of some players' smokeless tobacco habit.

Joe Garagiola, who quit, warned about chewing tobacco:

"I tell these guys, 'You may not like what I say, but with lung cancer you die of lung cancer,'" ... "With oral cancer, you die one piece at a time. They operate on your neck, they operate on your jaw, they operate on your throat." [33]

Bill Tuttle was a Major League player who made a big name for himself both through baseball and his anti-chewing tobacco efforts. Tuttle was an outfielder for the Detroit Tigers, Kansas City Athletics, and Minnesota Twins. He was an avid tobacco chewer; even his baseball cards pictured him with a bulge in his cheek from the tobacco. Nearly 40 years after he began using smokeless tobacco, Tuttle developed a tumor in his mouth so severe, it protruded through his skin. A few years before he died, Tuttle had many of his teeth, his jawbone, his gums, and his right cheekbone removed. He also had his taste buds removed. [34] Tuttle dedicated the last years of his life to speaking with Major League teams about not using chewing tobacco where television cameras could see the players so that children could not witness and be influenced by it. He also dedicated time to the National Spit Tobacco Education Program, which was being run by friend and former Major League player, Joe Garagiola. Tuttle died July 27, 1998, after a 5-year battle with cancer. [35]

Hall of Fame outfielder Tony Gwynn died of salivary cancer on June 16, 2014. He claimed the cancer was linked to his lifetime use of chewing and dipping tobacco. [36]

A 2016 MLB collective bargaining agreement prohibited all new Major League Baseball players from using smokeless tobacco. [37] [38]

Effect on youth

Debate exists over whether players should be banned from using tobacco products during the games. The Major League Baseball Players Association disagrees, claiming it is a legal substance, so is acceptable to be used during games. Harvard School of Public Health professor Gregory Connolly, however, says, "the use of smokeless tobacco by players has a powerful role-model effect on youth, particularly among young males in sport, some of whom remain addicted in future careers as professional athletes." [39] According to Connolly, one-quarter of Minor League players do not support allowing the use of chewing tobacco during games, and one-third of Major League players support abolishing it. [39] Due to health concerns, MLB was asked to ban the use of chewing tobacco during the 2011 World Series between the St. Louis Cardinals and Texas Rangers.

Statistics

Many believe that the widespread use of chewing tobacco by baseball players has led to a rampant increase in youth, and particularly teen, use.[ citation needed ] Additionally, teen use of smokeless tobacco has increased and it is more harmful and dangerous to tobacco user, while use of all tobacco products by teens has decreased. This is true especially among white and Hispanic males. [39] In 1970, five times as many 65-and-older males used smokeless tobacco as 18- to 24-year-olds did (12.7% of the population were 65+ male users, 2.2% of the population were 18–24 male users). More specifically, moist snuff use increased for males ages 18–24 from 1% of the population to 6.2% of the population, while 65+ male users decreased from 4% to 2.2%.[ citation needed ]

A 2009 survey by The U.S. Centers for Disease Control revealed that 8.9% of U.S. high-school students had used smokeless tobacco on at least 1 day during the 30 days before the survey. [40] Usage was more common among males (15.0%) than females (2.2%) and among Whites (11.9%) than Blacks (3.3%) or Hispanics (5.1%). The five states with the highest percentage of high-school users were Wyoming (16.2%), North Dakota (15.3%), South Dakota (14.6%), Montana (14.6%), and West Virginia (14.4%). [40]

Brands

Notable chewing tobacco brands include:

History

Historical advertisement of Grimm & Triepel Kruse chewing tobacco (1895) Grimm & Triepel NORDHAUSEN.jpg
Historical advertisement of Grimm & Triepel Kruse chewing tobacco (1895)

Chewing is one of the oldest methods of consuming tobacco. Indigenous peoples of the Americas in both North and South America chewed the leaves of the plant long before the arrival of Europeans.

The Southern United States was distinctive for their production of tobacco, which earned premium prices globally. Most farmers grew some for their own use, or traded with neighbors who grew it. Commercial sales became important in the late 19th century, as major tobacco companies arose in the South, becoming one of the largest employers in Winston-Salem, North Carolina, Durham, North Carolina, and Richmond, Virginia. Southerners dominated the tobacco industry in the United States. So much so that a concern as large as the Helme Tobacco Company, headquartered in New Jersey, was headed by former Confederate officer George Washington Helme. In 1938, R.J. Reynolds marketed 84 brands of chewing tobacco, 12 brands of smoking tobacco, and the top-selling Camel brand of cigarettes. Reynolds sold large quantities of chewing tobacco, even though that market peaked around 1910. [41]

Pete, in the 1928 cartoon Steamboat Willie, biting into a plug of chewing tobacco Steamboat Willie - Pete eating chewing tobacco.png
Pete, in the 1928 cartoon Steamboat Willie , biting into a plug of chewing tobacco

A historian of the American South in the late 1860s reported on typical usage in the region where it was grown, paying close attention to class and gender: [42]

The chewing of tobacco was well-nigh universal. This habit had been widespread among the agricultural population of America both North and South before the war. Soldiers had found the quid a solace in the field and continued to revolve it in their mouths upon returning to their homes. Out of doors where his life was principally led the chewer spat upon his lands without offence to other men, and his homes and public buildings were supplied with spittoons. Brown and yellow parabolas were projected to right and left toward these receivers, but very often without the careful aim which made for cleanly living. Even the pews of fashionable churches were likely to contain these familiar conveniences. The large numbers of Southern men, and these were of the better class (officers in the Confederate army and planters, worth $20,000 or more, and barred from general amnesty) who presented themselves for the pardon of President Johnson, while they sat awaiting his pleasure in the ante-room at the White House, covered its floor with pools and rivulets of their spittle. An observant traveller in the South in 1865 said that in his belief seven-tenths of all persons above the age of twelve years, both male and female, used tobacco in some form. Women could be seen at the doors of their cabins in their bare feet, in their dirty one-piece cotton garments, their chairs tipped back, smoking pipes made of corn cobs into which were fitted reed stems or goose quills. Boys of eight or nine years of age and half-grown girls smoked. Women and girls "dipped" in their houses, on their porches, in the public parlours of hotels and in the streets.

Chewing tobacco is still used, predominantly by young males in some parts of the American South, but also in other areas and age groups. In September 2006, both the Republican and Democratic candidates for Senator from Virginia admitted to chewing tobacco and agreed that it sets a bad example for children. [43]

In the late 19th century, during the peak in popularity of chewing tobacco in the Western United States, a device known as the spittoon was a ubiquitous feature throughout places both private and public (e.g. parlors and passenger cars). The purpose of the spittoon was to provide a receptacle for excess juices and spittle accumulated from the oral use of tobacco. As chewing tobacco's popularity declined throughout the years, the spittoon became merely a relic of the Old West and is rarely seen outside museums. Spittoons are still present on the floor of the U.S. Senate's old chamber, honored as tradition.

See also

Related Research Articles

<span class="mw-page-title-main">Areca nut</span> Fruit of the areca palm chewed as a stimulant

The areca nut or betel nut is the fruit of the areca palm. The palm is originally native to the Philippines, but was carried widely through the tropics by the Austronesian migrations and trade since at least 1500 BCE due to its use in betel nut chewing. It is widespread in cultivation and is considered naturalized in much of the tropical Pacific, South Asia, Southeast Asia, and parts of east Africa. It is not to be confused with betel leaves that are often used to wrap it. The practice of betel nut chewing, often together with other herbs as a stimulant drug, dates back thousands of years, and continues to the present day in many countries.

<span class="mw-page-title-main">Gutka</span> Tobacco preparation chewed in South Asia

Gutka, ghutka, guṭkha is a type of betel quid and chewing tobacco preparation made of crushed areca nut, tobacco, catechu, paraffin wax, slaked lime and sweet or savory flavourings, in India, Pakistan, other Asian countries, and North America.

<span class="mw-page-title-main">Smoking cessation</span> Process of discontinuing tobacco smoking

Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking. Tobacco smoke contains nicotine, which is addictive and can cause dependence. As a result, nicotine withdrawal often makes the process of quitting difficult.

<span class="mw-page-title-main">Betel nut chewing</span> Preparation of betel leaf and areca nut

Betel nut chewing, also called betel quid chewing or areca nut chewing, is a practice in which areca nuts are chewed together with slaked lime and betel leaves for their stimulant and narcotic effects, the primary psychoactive compound being arecoline. The practice is widespread in Southeast Asia, Micronesia, Island Melanesia, and South Asia. It is also found among both Han Chinese immigrants and indigenous peoples of Taiwan, Madagascar, and parts of southern China. It was introduced to the Caribbean in colonial times.

<span class="mw-page-title-main">Snus</span>

Snus is a tobacco product and non-tobacco nicotine product consumed by placing a pouch of powdered tobacco leaves or powdered non-tobacco plant fibers under your lip for nicotine to be absorbed through the oral mucosa. Whereas the nicotine in tobacco-based snus derives from tobacco leaves, the nicotine in non-tobacco snus can be either naturally or synthetically synthesized.

<span class="mw-page-title-main">Passive smoking</span> Inhalation of tobacco smoke by persons other than the intended active smoker

Passive smoking is the inhalation of tobacco smoke, called passive smoke, secondhand smoke (SHS) or environmental tobacco smoke (ETS), by individuals other than the active smoker. It occurs when tobacco smoke diffuses into the surrounding atmosphere as an aerosol pollutant, which leads to its inhalation by nearby bystanders within the same environment. Exposure to secondhand tobacco smoke causes many of the same diseases caused by active smoking, although to a lower prevalence due to the reduced concentration of smoke that enters the airway.

<span class="mw-page-title-main">Nicotine replacement therapy</span> Treatment for tobacco use disorder

Nicotine replacement therapy (NRT) is a medically approved way to treat people with tobacco use disorder by taking nicotine through means other than tobacco. It is used to help with quitting smoking or stopping chewing tobacco. It increases the chance of quitting tobacco smoking by about 55%. Often it is used along with other behavioral techniques. NRT has also been used to treat ulcerative colitis. Types of NRT include the adhesive patch, chewing gum, lozenges, nose spray, and inhaler. The use of multiple types of NRT at a time may increase effectiveness.

Nicotine gum is a chewing gum containing the active ingredient nicotine polacrilex. It is a type of nicotine replacement therapy (NRT) used alone or in combination with other pharmacotherapy for smoking cessation and for quitting smokeless tobacco.

<span class="mw-page-title-main">Dipping tobacco</span> Finely ground smokeless tobacco product

Dipping tobacco is a type of finely ground or shredded, moistened smokeless tobacco product. It is commonly and idiomatically known as dip. Dipping tobacco is used by placing a pinch, or "dip", of tobacco between the lip and the gum. The act of using it is called dipping. Dipping tobacco is colloquially called chaw, snuff, rub, or fresh leaf among other terms; because of this, it is sometimes confused with other tobacco products—namely dry snuff.

<span class="mw-page-title-main">Health effects of tobacco</span> Circumstances, mechanisms, and factors of tobacco consumption on human health

Tobacco products, especially when smoked or used orally, have serious negative effects on human health. Smoking and smokeless tobacco use is the single greatest cause of preventable death globally. As many as half of people who smoke tobacco or use it orally die from complications related to such use. It has been estimated that each year, in total about 6 million people die from tobacco-related causes, with 600,000 of these occurring in non-smokers due to secondhand smoke. It is further estimated to have caused 100 million deaths in the 20th century.

<span class="mw-page-title-main">Smokeless tobacco</span> Tobacco product used by means other than smoking

Smokeless tobacco is a tobacco product that is used by means other than smoking. Their use involves chewing, sniffing, or placing the product between gum and the cheek or lip. Smokeless tobacco products are produced in various forms, such as chewing tobacco, snuff, snus, and dissolvable tobacco products. Smokeless tobacco is widely used in South Asia and this accounts for about 80% of global consumption. All smokeless tobacco products contain nicotine and are therefore highly addictive. Quitting smokeless tobacco use is as challenging as smoking cessation.

<span class="mw-page-title-main">Varenicline</span> Nicotinic receptor agonist

Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation and for the treatment of dry eye disease. It is a nicotinic acetylcholine receptor partial agonist. When activated, this receptor releases dopamine in the nucleus accumbens, the brain's reward center, thereby reducing cravings and withdrawal symptoms with smoking cessation although less pronounced than a full agonist.

<span class="mw-page-title-main">Snuff (tobacco)</span> Smokeless tobacco type

Snuff is a type of smokeless tobacco product made from finely ground or pulverized tobacco leaves. It is snorted or "sniffed" into the nasal cavity, delivering nicotine and a flavored scent to the user. Traditionally, it is sniffed or inhaled lightly after a pinch of snuff is either placed onto the back surface of the hand, held pinched between thumb and index finger, or held by a specially made "snuffing" device.

Tobacco harm reduction (THR) is a public health strategy to lower the health risks to individuals and wider society associated with using tobacco products. It is an example of the concept of harm reduction, a strategy for dealing with the use of drugs. Tobacco smoking is widely acknowledged as a leading cause of illness and death, and reducing smoking is vital to public health.

<span class="mw-page-title-main">Electronic cigarette</span> Device that vaporizes a liquid nicotine solution for inhalation

An electronic cigarette (e-cigarette) or vape is a device that simulates tobacco smoking. It consists of an atomizer, a power source such as a battery, and a container such as a cartridge or tank. Instead of smoke, the user inhales vapor. As such, using an e-cigarette is often called "vaping". The atomizer is a heating element that vaporizes a liquid solution called e-liquid, which quickly cools into an aerosol of tiny droplets, vapor and air. The vapor mainly comprises propylene glycol and/or glycerin, usually with nicotine and flavoring. Its exact composition varies, and depends on several things including user behavior.

<span class="mw-page-title-main">Nicotine dependence</span> Chronic disease

Nicotine dependence is a state of dependence upon nicotine. Nicotine dependence is a chronic, relapsing disease defined as a compulsive craving to use the drug, despite social consequences, loss of control over drug intake, and emergence of withdrawal symptoms. Tolerance is another component of drug dependence. Nicotine dependence develops over time as a person continues to use nicotine. The most commonly used tobacco product is cigarettes, but all forms of tobacco use and e-cigarette use can cause dependence. Nicotine dependence is a serious public health problem because it leads to continued tobacco use, which is one of the leading preventable causes of death worldwide, causing more than 8 million deaths per year.

<span class="mw-page-title-main">Naswar</span> Dipping tobacco

Naswār, also called nās, nāsor or nasvay, is a moist, powdered tobacco dip consumed mostly in Afghanistan, and surrounding countries, including Pakistan, India and neighboring Central Asian republics. Naswar is stuffed in the floor of the mouth under the lower lip, or inside the cheek, known as butt style stuffing, for extended periods of time, usually for 15 to 30 minutes. It is similar to dipping tobacco and snus. Swabi, Bannu, Dera Ismail Khan, Charsadda, Mohmand and Herat are renowned for their production of some of the highest quality Naswar.

The use of electronic cigarettes (vaping) carries health risks. The risk depends on the fluid and varies according to design and user behavior. In the United Kingdom, vaping is considered by some to be around 95% less harmful than tobacco after a controversial landmark review by Public Health England.

The scientific community in the United States and Europe are primarily concerned with the possible effect of electronic cigarette use on public health. There is concern among public health experts that e-cigarettes could renormalize smoking, weaken measures to control tobacco, and serve as a gateway for smoking among youth. The public health community is divided over whether to support e-cigarettes, because their safety and efficacy for quitting smoking is unclear. Many in the public health community acknowledge the potential for their quitting smoking and decreasing harm benefits, but there remains a concern over their long-term safety and potential for a new era of users to get addicted to nicotine and then tobacco. There is concern among tobacco control academics and advocates that prevalent universal vaping "will bring its own distinct but as yet unknown health risks in the same way tobacco smoking did, as a result of chronic exposure", among other things.

The chemical constituents of different types of snus vary, and population-level studies suggest that the disease risks vary as well. Using snus is harmful to health, although much less than smoking tobacco.

References

  1. Vidyasagaran, A. L.; Siddiqi, K.; Kanaan, M. (2016). "Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis" (PDF). European Journal of Preventive Cardiology. 23 (18): 1970–1981. doi:10.1177/2047487316654026. ISSN   2047-4873. PMID   27256827. S2CID   206820997.
  2. Lipari, R. N; Van Horn, S. L (31 May 2017). "Trends in Smokeless Tobacco Use and Initiation: 2002 to 2014". Substance Abuse and Mental Health Services Administration. PMID   28636307.{{cite journal}}: Cite journal requires |journal= (help)PD-icon.svg This article incorporates text from this source, which is in the public domain .
  3. Vidyasagaran, A. L.; Siddiqi, K.; Kanaan, M. (2016). "Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis" (PDF). European Journal of Preventive Cardiology. 23 (18): 1970–1981. doi:10.1177/2047487316654026. ISSN   2047-4873. PMID   27256827. S2CID   206820997.
  4. Gupta, Ruchika; Gupta, Sanjay; Sharma, Shashi; Sinha, Dhirendra N; Mehrotra, Ravi (2019-01-01). "Risk of Coronary Heart Disease Among Smokeless Tobacco Users: Results of Systematic Review and Meta-Analysis of Global Data". Nicotine & Tobacco Research. 21 (1): 25–31. doi:10.1093/ntr/nty002. ISSN   1469-994X. PMC   6941711 . PMID   29325111.
  5. 1 2 Hajat, C.; Stein, E.; Ramstrom, L.; Shantikumar, S.; Polosa, R. (4 December 2021). "The health impact of smokeless tobacco products: a systematic review". Harm Reduction Journal. 18 (1): 123. doi: 10.1186/s12954-021-00557-6 . ISSN   1477-7517. PMC   8643012 . PMID   34863207.
  6. 1 2 Lipari, R. N; Van Horn, S. L (31 May 2017). "Trends in Smokeless Tobacco Use and Initiation: 2002 to 2014". Substance Abuse and Mental Health Services Administration. PMID   28636307.{{cite journal}}: Cite journal requires |journal= (help)PD-icon.svg This article incorporates text from this source, which is in the public domain .
  7. Abrams, David B.; Glasser, Allison M.; Pearson, Jennifer L.; Villanti, Andrea C.; Collins, Lauren K.; Niaura, Raymond S. (2018). "Harm Minimization and Tobacco Control: Reframing Societal Views of Nicotine Use to Rapidly Save Lives". Annual Review of Public Health. 39 (1): 193–213. doi: 10.1146/annurev-publhealth-040617-013849 . ISSN   0163-7525. PMC   6942997 . PMID   29323611. Creative Commons by small.svg  This article incorporates text by David B. Abrams, Allison M. Glasser, Jennifer L. Pearson, Andrea C. Villanti, Lauren K. Collins, and Raymond S. Niaura available under the CC BY 4.0 license.
  8. Chugh, Aastha; Arora, Monika; Jain, Neha; Vidyasagaran, Aishwarya; Readshaw, Anne; Sheikh, Aziz; Eckhardt, Jappe; Siddiqi, Kamran; Chopra, Mansi; Mishu, Masuma Pervin; Kanaan, Mona; Rahman, Muhammad Aziz; Mehrotra, Ravi; Huque, Rumana; Forberger, Sarah (June 2023). "The global impact of tobacco control policies on smokeless tobacco use: a systematic review". The Lancet Global Health. 11 (6): e953–e968. doi:10.1016/S2214-109X(23)00205-X. PMID   37202029.
  9. "How To Smoke Rope & Twist Tobacco – With Pipe and Pen". Archived from the original on 31 May 2015. Retrieved 30 May 2015.
  10. "Recommendation on smokeless tobacco products" (PDF). World Health Organization. 2017. pp. 1–9.
  11. "Health Risks of Smokeless Tobacco". American Cancer Society. 13 November 2015.
  12. "Smokeless Tobacco and Cancer". United States Department of Health and Human Services. National Cancer Institute at the National Institutes of Health. 25 October 2010.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  13. Royal College of Physicians of London. Tobacco Advisory Group (2002). Protecting Smokers, Saving Lives: The Case for a Tobacco and Nicotine Regulatory Authority. Royal College of Physicians. pp. 5–. ISBN   978-1-86016-177-3.
  14. Sinha, Dhirendra N; Suliankatchi, Rizwan A; Gupta, Prakash C; Thamarangsi, Thaksaphon; Agarwal, Naveen; Parascandola, Mark; Mehrotra, Ravi (2016). "Global burden of all-cause and cause-specific mortality due to smokeless tobacco use: systematic review and meta-analysis". Tobacco Control. 27 (1): tobaccocontrol–2016–053302. doi:10.1136/tobaccocontrol-2016-053302. ISSN   0964-4563. PMID   27903956. S2CID   10968200.
  15. Chugh, Aastha; Arora, Monika; Jain, Neha; Vidyasagaran, Aishwarya; Readshaw, Anne; Sheikh, Aziz; Eckhardt, Jappe; Siddiqi, Kamran; Chopra, Mansi; Mishu, Masuma Pervin; Kanaan, Mona; Rahman, Muhammad Aziz; Mehrotra, Ravi; Huque, Rumana; Forberger, Sarah (June 2023). "The global impact of tobacco control policies on smokeless tobacco use: a systematic review". The Lancet Global Health. 11 (6): e953–e968. doi:10.1016/S2214-109X(23)00205-X. PMID   37202029.
  16. Niaz, Kamal; Maqbool, Faheem; Khan, Fazlullah; Bahadar, Haji; Ismail Hassan, Fatima; Abdollahi, Mohammad (2017). "Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer". Epidemiology and Health. 39: e2017009. doi:10.4178/epih.e2017009. ISSN   2092-7193. PMC   5543298 . PMID   28292008. Creative Commons by small.svg  This article incorporates text by Kamal Niaz, Faheem Maqbool, Fazlullah Khan, Haji Bahadar, Fatima Ismail Hassan, Mohammad Abdollahi available under the CC BY 4.0 license.
  17. Vidyasagaran, A. L.; Siddiqi, K.; Kanaan, M. (2016). "Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis" (PDF). European Journal of Preventive Cardiology. 23 (18): 1970–1981. doi:10.1177/2047487316654026. ISSN   2047-4873. PMID   27256827. S2CID   206820997.
  18. Gupta, Ruchika; Gupta, Sanjay; Sharma, Shashi; Sinha, Dhirendra N; Mehrotra, Ravi (2019-01-01). "Risk of Coronary Heart Disease Among Smokeless Tobacco Users: Results of Systematic Review and Meta-Analysis of Global Data". Nicotine & Tobacco Research. 21 (1): 25–31. doi:10.1093/ntr/nty002. ISSN   1469-994X. PMC   6941711 . PMID   29325111.
  19. Lipari, R. N; Van Horn, S. L (31 May 2017). "Trends in Smokeless Tobacco Use and Initiation: 2002 to 2014". Substance Abuse and Mental Health Services Administration. PMID   28636307.{{cite journal}}: Cite journal requires |journal= (help)PD-icon.svg This article incorporates text from this source, which is in the public domain .
  20. "Smokeless Tobacco and Cancer". United States Department of Health and Human Services. National Cancer Institute at the National Institutes of Health. 25 October 2010.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  21. ERS (2019-05-29). "ERS Position Paper on Tobacco Harm Reduction". ERS - European Respiratory Society. Retrieved 2024-05-30.
  22. Vidyasagaran, A. L.; Siddiqi, K.; Kanaan, M. (2016). "Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis" (PDF). European Journal of Preventive Cardiology. 23 (18): 1970–1981. doi:10.1177/2047487316654026. ISSN   2047-4873. PMID   27256827. S2CID   206820997.
  23. Aupérin A (May 2020). "Epidemiology of head and neck cancers: an update". Current Opinion in Oncology. 32 (3): 178–186. doi:10.1097/CCO.0000000000000629. PMID   32209823. S2CID   214644380.
  24. Wyss AB, Hashibe M, Lee YA, Chuang SC, Muscat J, Chen C, et al. (November 2016). "Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium". American Journal of Epidemiology. 184 (10): 703–716. doi:10.1093/aje/kww075. PMC   5141945 . PMID   27744388.
  25. Lipari, R. N; Van Horn, S. L (31 May 2017). "Trends in Smokeless Tobacco Use and Initiation: 2002 to 2014". Substance Abuse and Mental Health Services Administration. PMID   28636307.{{cite journal}}: Cite journal requires |journal= (help)PD-icon.svg This article incorporates text from this source, which is in the public domain .
  26. Niaz, Kamal; Maqbool, Faheem; Khan, Fazlullah; Bahadar, Haji; Ismail Hassan, Fatima; Abdollahi, Mohammad (2017). "Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer". Epidemiology and Health. 39: e2017009. doi:10.4178/epih.e2017009. ISSN   2092-7193. PMC   5543298 . PMID   28292008. Creative Commons by small.svg  This article incorporates text by Kamal Niaz, Faheem Maqbool, Fazlullah Khan, Haji Bahadar, Fatima Ismail Hassan, Mohammad Abdollahi available under the CC BY 4.0 license.
  27. 1 2 Drope, Jeffrey; Cahn, Zachary; Kennedy, Rosemary; Liber, Alex C.; Stoklosa, Michal; Henson, Rosemarie; Douglas, Clifford E.; Drope, Jacqui (2017). "Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine". CA: A Cancer Journal for Clinicians. 67 (6): 449–471. doi: 10.3322/caac.21413 . ISSN   0007-9235. PMID   28961314.
  28. 1 2 3 Vidyasagaran, A. L.; Siddiqi, K.; Kanaan, M. (2016). "Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis" (PDF). European Journal of Preventive Cardiology. 23 (18): 1970–1981. doi:10.1177/2047487316654026. ISSN   2047-4873. PMID   27256827. S2CID   206820997.
  29. Gupta, Ruchika; Gupta, Sanjay; Sharma, Shashi; Sinha, Dhirendra N; Mehrotra, Ravi (2019-01-01). "Risk of Coronary Heart Disease Among Smokeless Tobacco Users: Results of Systematic Review and Meta-Analysis of Global Data". Nicotine & Tobacco Research. 21 (1): 25–31. doi:10.1093/ntr/nty002. ISSN   1469-994X. PMC   6941711 . PMID   29325111.
  30. Chugh, Aastha; Arora, Monika; Jain, Neha; Vidyasagaran, Aishwarya; Readshaw, Anne; Sheikh, Aziz; Eckhardt, Jappe; Siddiqi, Kamran; Chopra, Mansi; Mishu, Masuma Pervin; Kanaan, Mona; Rahman, Muhammad Aziz; Mehrotra, Ravi; Huque, Rumana; Forberger, Sarah (June 2023). "The global impact of tobacco control policies on smokeless tobacco use: a systematic review". The Lancet Global Health. 11 (6): e953–e968. doi:10.1016/S2214-109X(23)00205-X. PMID   37202029.
  31. 1 2 "Smokeless Tobacco: Health Effects". Centers for Disease Control and Prevention. 1 December 2016.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  32. Bird, Patrick J.. "Chewing Tobacco the Spitting Image of Baseball". Ocala Star-Banner April 11, 1989: 7C.
  33. "Garagiola, Who Quit, Warns About Chewing Tobacco" Archived 2016-02-04 at the Wayback Machine , Sports of The Times By George Vecsey Published: May 29, 2010
  34. "Smokeless Tobacco". KidsHealth.org Archived 2010-03-18 at the Wayback Machine . April 28, 2010.
  35. Goldstein, Richard. "Big League Anti-Tobacco Advocate Dies". No-Smoking.org Archived 2007-09-27 at the Wayback Machine July 30, 1998.
  36. Lawrence, Andrew. "Tony Gwynn's last days: Cancer, tobacco and the death of a legend". Sports Illustrated. Archived from the original on 29 December 2016. Retrieved 28 December 2016.
  37. "Report: CBA includes smokeless tobacco ban for new players". ESPN.com. December 2016. Archived from the original on 29 December 2016. Retrieved 28 December 2016.
  38. "MLB takes a swing at smokeless tobacco". The Washington Post. Archived from the original on 28 December 2016. Retrieved 28 December 2016.
  39. 1 2 3 Smith, Donna. "Smokeless Tobacco Use Rising Among Teens" Archived 2021-01-28 at the Wayback Machine . Reuters. April 28, 2010.
  40. 1 2 "Youth Risk Behavior Surveillance --- United States, 2009" Archived 2017-09-05 at the Wayback Machine . Center for Disease Control – June 4, 2010.
  41. "globalink". Archived from the original on 26 September 2006. Retrieved 30 May 2015.
  42. A History of the United States since the Civil War Volume: 1. by Ellis Paxson Oberholtzer; 1917. p. 93.
  43. Fiske, Warren; Eisman, Dale (18 September 2006). "'Meet the Press' hosts debate for Allen, Webb". The Virginian-Pilot . Archived from the original on 10 December 2007.