| Name | Birth | Birthplace | Death | Place of death | Notes |
|---|
| Persecution under Septimus Severus (202–210) begins |
| Irenaeus [1] | 130 | Smyrna | 202 | Lugdunum | Bishop of Lyons |
| Leonides of Alexandria [2] | | | 202 | Alexandria, Egypt; | father of Origen |
| Plutarch, Potamiaena, and Companions [3] | | | 202 | Alexandria, Egypt | |
| Charalampias [4] | 89 | Magnesia, Greece | 203 | Antioch, Pisidia | |
| Gundenis | | | 203 | Carthage, Africa Province | |
| Perpetua and Felicity [5] | | | 203 | Carthage, Africa Province | |
| Zoticus of Comana [6] | | | 204 | | Bishop of Comana |
| Abdon and Sennen [7] | | | 205 | | |
| Basilides and Potamiana | | | 205 | Alexandria, Egypt | |
| Andeolus | | Smyrna | 208 | Viviers, Gaul | |
| Serapion of Antioch | | | 211 | | Patriarch of Antioch |
| Felix, Fortunatus, and Achilleus | | | 212 | Valence, Gaul | introduced Christianity to Valence, Drôme |
| Ferreolus and Ferrutio | | | 212 | | |
| Mavilus of Adrumetum | | | 212 | Adrumetum, Africa Province | killed by wild beasts |
| Narcissus of Jerusalem | 100 | | 212 | Aelia Capitolina Syria Palaestina | Patriarch of Jerusalem |
| Urciscenus | | | 216 | | Bishop of Pavia (183-216) |
| Asclepiades of Antioch | | | 217 | | Patriarch of Antioch (211-217) |
| Clement of Alexandria | 150 | Athens, Greece | 217 | | |
| Zephyrinus | | Rome, Roman Empire | 217 | Rome, Roman Empire | Pope |
| Theodore, Philippa, and Companions | | | 220 | Pamphylia | |
| Callixtus I (Callistus) | | | 222 | Todi, Roman Empire | Pope |
| Asterius of Ostia | | | 223 | Ostia, Roman Empire | |
| Martina of Rome | | | 228 | Rome, Roman Empire | |
| Cecilia [8] | | Rome, Roman Empire | 230 | Sicily, Roman Empire | |
| Tatiana of Rome [9] | | Rome, Roman Empire | 230 | Rome, Roman Empire | |
| Thespesius | | | 230 | Cappadocia | |
| Urban I | | Rome, Roman Empire | 230 | Rome, Roman Empire | Pope |
| Demetrius of Alexandria | | Alexandria, Roman Empire | 231 | | Pope of Alexandria |
| Calepodius | | | 232 | | |
| Persecution under Maximinus Thrax (235-238) begins |
| Andrew of Trier | | | 235 | | Bishop of Trier |
| Barbara [10] | | Nicomedia, Roman Empire | 235 | Nicomedia, Roman Empire | |
| Florentius and Felix | | | 235 | Furcona, Roman Empire | |
| Pontian | | | 235 | Sardinia, Roman Empire | Pope |
| Quiriacus | | | 235 | | Bishop of Ostia |
| Anterus | | | 236 | Rome, Roman Empire | Pope |
| Hippolytus | 170 | Rome, Roman Empire | 236 | Sardinia, Roman Empire | |
| Orentius and Patientia | | Osca, Hispania | 240 | Aragon, Hispania | |
| Heraclas | | | 247 | | Patriarch of Alexandria |
| Apollonia [11] | | | 249 | Alexandria, Egypt | |
| Cointha (Quinta) | | | 249 | Alexandria, Egypt | |
| Cyriaca (Dominica) [12] | Rome, Roman Empire | | 249 | | |
| Monas | | | 249 | | Bishop of Milan |
| Persecution under Decius (250-251) begins |
| Agabius | | | 250 | | Bishop of Verona |
| Alexander of Fermo | | | 250 | | Bishop of Fermo |
| Alexander | | | 250 | | |
| Ammonaria (two women with the same name) | | | 250 | | |
| Babylas of Antioch | | | 250 | | Patriarch of Antioch |
| Barsimaeus | | | 250 | | Bishop of Edessa |
| Bassus | | | 250 | | Bishop of Nice |
| Cassian of Imola | | | 250 | | |
| Castus and Emilius | | | 250 | | |
| Christopher | | | 250 | | |
| Cyril of Caesarea | | | 250 | | |
| Denis, Rusticus and Eleutherius | | | 250 | | |
| Epicharis | | | 250 | | |
| Epimachus | | | 250 | | |
| Fabian [10] | | | 250 | | Pope |
| Faustus, Abibus and Dionysius of Alexandria | | | 250 | | |
| Felinus and Gratian | | | 250 | | |
| Florentius | | | 250 | | |
| Fusca and Marura | | | 250 | | |
| Germanus | | | 250 | | |
| Heliconis | | | 250 | | |
| Heron | | | 250 | | |
| Lucian and Marcian | | | 250 | | |
| Macarius | | | 250 | | |
| Macarius | | | 250 | | |
| Maximus of Aquila | | | 250 | | |
| Maximus of Nola | | | 250 | | Bishop of Nola |
| Maximus of Ephesus | | | 250 | | |
| Mercurius | | | 250 | | |
| Metranus (Metras) | | | 250 | | |
| Minias (Miniato) | | | 250 | | |
| Moses (Moysetes) | | | 250 | | |
| Moseus and Ammonius | | | 250 | | |
| Myron | | | 250 | | Bishop of Crete |
| Nemesion | | | 250 | | |
| Papias | | | 250 | | |
| Paramon and Companions | | | 250 | | |
| Parasceva | | | 250 | | |
| Parmenius | | | 250 | | |
| Pionius | | | 250 | | |
| Saturninus of Rome | | | 250 | | |
| Saturninus (Sernin) | | | 250 | | Bishop of Toulouse |
| Saturninus, Thrysus, and Victor | | | 250 | | |
| Secundian | | | 250 | | |
| Secundina | | | 250 | | |
| Ten Martyrs of Crete | | | 250 | | |
| The Seven Sleepers of Ephesus | | | 250 | | |
| Troadius | | | 250 | | |
| Venatius of Camerino | | | 250 | | |
| Vissa | | | 250 | | |
| Agatha | | | 251 | | |
| Agatho | | | 251 | | |
| Alexander | | | 251 | | Bishop of Jerusalem |
| Alphius | | | 251 | | |
| Caerealis and Sallustia | | | 251 | | |
| Callinica and Basilissa | | | 251 | | |
| Conon the Gardener | | | 251 | | martyr |
| Galation (Galacteon) and Episteme | | | 251 | | |
| Maximus and Olympiades (Olympias) | | | 251 | | |
| Maximus | | | 251 | | |
| Menignus | | | 251 | | |
| Moses | | | 251 | | |
| Myrope | | | 251 | | |
| Nestor | | | 251 | | Bishop of Magydos |
| Pergentinus and Laurentinus | | | 251 | | |
| Peter of Lampsacus, Andrew, Paul, and Denise (Dionysia) | | | 251 | | |
| Quintus, Simplicius, and companions | | | 251 | | |
| Thyrsus, Leucius, and Callinicus | | | 251 | | |
| Trypho (Tryphon) | | | 251 | | |
| Serapion | | | 252 | | |
| Cornelius | | | 253 | | Pope |
| Victoria of Tivoli | | | 253 | | |
| Felician | 160 | | 254 | | |
| Lucius I | | | 254 | | Pope |
| Messalina | | | 254 | | |
| Martyrs of Saragossa | | | 254 | Zaragoza | |
| Maximus | | | 255 | | |
| Paternus | | | 255 | | |
| Restituta | | | 255 | | |
| Tarsicius | | | 255 | | |
| Venantius | | | 255 | | Bishop of Dalmatia |
| Rogatian | | | 256 | | |
| Persecution under Valerian (257-259) begins |
| Anastasia II and Cyril | | | 257 | | |
| Athanasius | | | 257 | | Bishop of Tarsus |
| Basilla of Rome | | Rome | 257 | Rome | |
| Dionysius, Faustus, Gaius, Peter, Paul and companions | | | 257 | | |
| Eugenia | | | 257 | | |
| Protus and Hyacinthus | | | 257 | | |
| Quadratus of Herbipolis | | | 257 | | |
| Rufina and Secunda | | | 257 | | |
| Stephen I | | | 257 | | Pope |
| Tertullinus | | | 257 | | |
| Agapitus | | | 258 | | |
| Codratus of Corinth, Dionysius, Cyprian, Anectus, Paul, and Crescens | | | 258 | | |
| Crescentian | | | 258 | | |
| Curomotus | | | 258 | | Bishop of Iconium |
| Cyprian | | | 258 | | Bishop of Carthage |
| Jovinus and Basileus | | | 258 | | |
| Lawrence of Rome | 225 | | 258 | | |
| Romanus Ostiarius | | | 258 | | |
| Sixtus II, Pope and martyr, and Companions | | | 258 | | |
| Twelve Holy Brothers | | | 258 | | |
| Saint Agapius of Spain | | | 259 | | |
| Candidus | | | 259 | | |
| Digna and Emerita | | | 259 | | |
| Fructuosus, Augurius and Eulogius | | | 259 | | |
| Justin | | | 259 | | |
| Marian, James, and companions | | | 259 | | |
| Montanus, Flavian, Julian, Lucius, Victoricus, and 5 Companions | | | 259 | | |
| Patroclus | | | 259 | | |
| Polyeuctus | | | 259 | | |
| Pontian | | | 259 | | |
| Alexander, Malchus and Priscus | | | 260 | | |
| Felix of Nola | | | 260 | | |
| Leo and Paregorius | | | 260 | | |
| Lucilla, Antoninus, Eugene, Flora, Theodore, Aucejas, and 18 Companions | | | 260 | | |
| Martyrs of Utica | | | 260 | | |
| Peter, Julian, and Companions | | | 260 | | |
| Priscus, Malchus, and Alexander | | | 260 | | |
| Regulus (Rieul, Rule) | | | 260 | | Bishop of Civitas Silvanectium |
| Martyrs of Alexandria | | | 261 | | |
| Peregrine | | | 261 | | Bishop of Auxerre |
| Agrippina [13] | | | 262 | | |
| Asterius | | | 262 | Caesarea Palaestina | |
| Marinus, Roman soldier and martyr, | | | 262 | Caesarea Palaestina | |
| Heraclius and Zosimus | | | 263 | | |
| Cassius | | | 264 | | |
| Antholian (Anatolianus) | | | 265 | | |
| Antidius (Tude) | | | 265 | | Bishop of Besançon |
| Dionysius | | | 265 | | Patriarch of Antioch |
| Dionysius | | | 268 | | Pope |
| Zama | | | 268 | | Bishop of Bologna |
| Athenodorus | | | 269 | | |
| Theodosius | | | 269 | | |
| Valentine | | | 269 | | |
| Persecution under Aurelian (270-275) begins |
| Aurea | | | 270 | | |
| Gregory Thaumaturgus (the wonderworker) | | | 270 | | Bishop of Neocaesarea |
| Heliodorus | | | 270 | | |
| Hermes | | | 270 | | |
| Honestus | | | 270 | | |
| Martha | | | 270 | | |
| Paul and Juliana | | | 270 | | |
| Philip | | | 270 | | Bishop of Fermo |
| Prisca | | | 270 | | |
| Theodotus | | | 270 | | |
| Restituta of Sora | | | 271 | | |
| Agapitus | | | 272 | | |
| Julia of Troyes | | | 272 | | |
| Priscus (Prix) and Companions | | | 272 | | |
| Reverianus | | | 272 | | |
| Sabas (the Goth) | | | 272 | | |
| Agpae (Agape) | | | 273 | | |
| Lucillian, Paula, Claudius, Dionysius, Hypatius, and Paul | | | 273 | | |
| Saturninus, Castulus, Magnus, and Lucius | | | 273 | | |
| Anastasius Cornicularius | | | 274 | | |
| Columba of Sens | | | 274 | | |
| Felix I | | | 274 | | Pope |
| Alexander the Charcoal-Burner | | | 275 | | Bishop of Comana |
| Basilides and 22 Companions | | | 275 | | |
| Conon and Conon | | | 275 | | |
| Mamas [14] | | | 275 | | |
| Philomenus | | | 275 | | |
| Trophimus | | | 280 | | Bishop of Arles |
| Maximus | | | 282 | | |
| Anatolius | | | 283 | | Bishop of Laodicea |
| Cosmas and Damian [10] | | | 283 | | |
| Diodorus and Marianus | | | 283 | | |
| Justus and Abundius | | | 283 | | |
| Pelagius | | | 283 | | |
| Ariston | | | 284 | | |
| Chrysanthus and Daria | | | 284 | | |
| Claudius | | | 284 | | |
| Hilarius of Aquileia (Hilary of Panonia) | | | 284 | | Bishop of Aquileia, Italy. Beheaded in the persecutions of Numerian |
| Maximilian | | | 284 | | Bishop of Lorch |
| Thalelaeus | | | 284 | | |
| Theopemptus (Theopompus), Bishop of Nicomedia and martyr, and Theonas | | | 284 | | |
| Victorinus and Companions | | | 284 | | |
| Castulus | | | 286 | | |
| Crispin and Crispian | | | 286 | | |
| Marcus and Marcellianus (Mark and Marcellian), deacons | | | 286 | | |
| Piaton (Piat) | | | 286 | | |
| Regina (Reine) | | | 286 | | |
| Tranquillinus | | | 286 | | |
| Victor and Companions | | | 286 | | |
| Victor and Ursus | | | 286 | | |
| Zoe [15] | | | 286 | | |
| Alban | | | 287 | | |
| Boniface of Tarsus | | | 287 | | |
| Crescentian | | | 287 | | |
| Faith (Foy, Fides) | | | 287 | | |
| Maurice and Companions | | | 287 | | |
| Maxentius | | | 287 | | |
| Palmatius | | | 287 | | |
| Quentin (Quintinius) | | | 287 | | |
| Sabinus | | | 287 | | |
| Valerius and Rufinus | | | 287 | | |
| Victoricus, Fuscian, and Gentian | | | 287 | | |
| Sebastian | 257 | | 288 | | |
| Donatian and Rogatian | | | 289 | | |
| Apollinaris | | | 290 | | |
| Firmus and Rusticus | | | 290 | | |
| Hermes and Adrian | | | 290 | | |
| Justin | | | 290 | | |
| Lucian of Beauvais | | | 290 | | |
| Paul | | | 290 | | Bishop of Narbonne |
| Pompeius | | | 290 | | Bishop of Pavia |
| Rhipsime, Gaiana, and Companions | | | 290 | | |
| Serena | | | 290 | | |
| Victor of Marseilles | | | 290 | | |
| Vincent of Agen | | | 292 | | |
| Aquilina | | | 293 | | |
| Archelais, Thecla, and Susanna | | | 293 | | |
| Carpophorus | | | 295 | | |
| Domnio | | | 295 | | |
| Maximilian of Tebessa | 273 | | 295 | | |
| Maximus, Alexander, Claudius, Cutias, and Praepedigna | | | 295 | | |
| Meletius | | | 295 | | Bishop of Pontus |
| Rufus and Carpophorus | | | 295 | | |
| Tiburtius and Susanna | | | 295 | | |
| Urpasian | | | 295 | | |
| Felix and Fortunatus | | | 296 | | |
| Gabinus | | | 296 | | |
| Caius | | | 296 | | Pope |
| Octavius | | | 297 | | |
| Primus and Felician | | | 297 | | |
| Romanus of Samosata | | | 297 | Samosata, Syria | |
| Ananias III | | | 298 | | |
| Cassian | | | 298 | | |
| Marcellus the Centurion | | | 298 | | |
| Timothy and Maura (Martha) | | | 298 | | |
| Restitutus | | | 299 | | |
| Agileus | | | 300 | | |
| Agrippinus | | | 300 | | Bishop of Naples |
| Alexandra, Claudia, Euphrasia, Matrona, Juliana, Euphemia, Theodosia, Derphuta and her sister | | | 300 | | |
| Amandus, Alexander, Lucius and Audaldus | | | 300 | | |
| Andrew the Tribune | | | 300 | | |
| Ardalion | | | 300 | | |
| Autonomous | | | 300 | | |
| Callistratus | | | 300 | | |
| Candida | | | 300 | | |
| Carpophorus and Abundius | | | 300 | | |
| Cindeus | | | 300 | | |
| Clerus | | | 300 | | |
| Crescentius of Perugia | | | 300 | | |
| Dasius | | | 300 | | |
| Epicharis | | | 300 | | |
| Flavius | | | 300 | | Bishop of Nicomedia |
| Hermes | | | 300 | | |
| Hieron | | | 300 | | |
| Hieronides | | | 300 | | |
| Jovinian | | | 300 | | |
| Leontius | | | 300 | | |
| Lucy and Geminian | | | 300 | | |
| Lupercus (Luperculus) | | | 300 | | |
| Marciana | | | 300 | | |
| Mary the Slave or Rome | | | 300 | | |
| Memmius (Menge, Meinge) | | | 300 | | Bishop of Châlons-sur-Marne |
| Mercurius | | | 300 | | |
| Montanus | | | 300 | | |
| Papas | | | 300 | | |
| Papulus | | | 300 | | |
| Sanctinus | | | 300 | | Bishop of Meaux |
| Severinus | | | 300 | | Bishop of Trier |
| Theonas | | | 300 | | Patriarch of Antioch |
| Theophilus Scholasticus (the Lawyer) | | | 300 | | |
| Trophimus and Thalus | | | 300 | | |
| Zeno | | | 300 | | |