Cordylobia anthropophaga

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Cordylobia anthropophaga
Cordylobia anthropophaga00.png
Adult
Cordylobia anthropophaga01.png
Larva
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Calliphoridae
Genus: Cordylobia
Species:
C. anthropophaga
Binomial name
Cordylobia anthropophaga
(Blanchard, 1872)
Synonyms

Ochromyia anthropophaga Blanchard, 1872

Cordylobia anthropophaga, the mango fly, tumbu fly, tumba fly, putzi fly, or skin maggot fly, is a species of blow-fly common in East and Central Africa. It is a parasite of large mammals (including humans) during its larval stage. [1] C. anthropophaga is found in the tropics of Africa and is a common cause of myiasis in humans in the region. [2]

Contents

Its specific epithet anthropophaga derives from the Greek word anthropophagos, "human eater".

The mode of infection by the Cayor Worm. Doctors Rodhain and Bequaert conclude, from their observations in the Congo Free State, that Cordylobia anthropophaga lays its eggs on the ground. The larvae, known generally as Cayor Worms, crawl over the soil until they come in contact with a mammal, penetrate the skin and lie in the subcutaneous tissue, causing the formation of tumors. On reaching full growth, the larvae leave the host, fall to the ground, bury themselves and then pupate. This fly is said to be the most common cause of human or animal myiasis in tropical Africa, from Senegal to Natal. In the region of Lower Katanga where these investigations were made, dogs appeared to be the principal hosts, although Cordylobia larvae were found also in guinea-pigs, a monkey, and two humans. The larvae are always localized on those parts of the hosts which come in immediate contact with the soil."

Ann. Soc. Entom. de Belgique, Iv, pp. 192–197, 1911) summary translation in Entomological News. 1911 Vol. xxii:467.

History of discovery

The larvae of the tumbu fly, Cordylobia anthropophaga, were first described in Senegal in 1862, and Blanchard first described the adult and gave it its name in 1872. In 1903, Grünberg placed the tumbu fly in a new genus, Cordylobia . [3]

Life cycle

Female tumbu flies deposit around 300 eggs in sandy soil, often contaminated with feces. The hatched larvae can remain viable in the soil for 9–15 days, when they need to find a host to continue developing. [4] If a larva finds a host, it penetrates the skin and takes 8–12 days developing through three larval stages before it reaches the prepupal stage. It then leaves the host, drops to the ground, buries itself, and pupates. It then becomes an adult fly able to reproduce and begin the cycle all over again. [5]

Clinical presentation in humans

Successful penetrations in humans results in furuncular (boil-like) myiasis, typically on the backs of arms or about the waist, lower back, or buttocks. [6]

C. anthropophaga rarely causes severe problems, and mainly causes cutaneous myiasis. Geary et al. describe the presentation of cutaneous myiasis caused by the tumbu fly: "At the site of penetration, a red papule forms and gradually enlarges. At first the host may experience only intermittent, slight itching, but pain develops and increases in frequency and intensity as the lesions develop into a furuncle. The furuncle's aperture opens, permitting fluids containing blood and waste products of the maggot to drain." [5]

Transmission

Female tumbu flies lay their eggs in soil contaminated with feces or urine or on damp clothing or bed linens. Damp clothing hanging to dry makes for a perfect spot. The larvae hatch in 2–3 days and attach to unbroken skin and penetrate the skin, producing swelling and infection. [7] If the larvae hatch in soil, any disturbance of the soil causes them to wriggle to the surface to penetrate the skin of the host. [5]

Reservoir and vector

A natural reservoir is defined as an organism that can harbor a pathogen indefinitely with no ill effects. Although C. anthropophaga larvae can cause ill effects for animal hosts, relative to myiasis in humans, animal hosts are reservoirs.

Many animals are hosts of C. anthropophaga. The dog is the most common domestic host and several species of wild rats are the preferred field hosts. Domestic fowl are dead-end hosts; the larvae cannot develop when they enter the tissue of a fowl. [3]

Humans are, in fact, accidental hosts; tumbu fly larvae do not usually infect humans. [2]

A vector is an organism that carries the parasites (the larvae) from one host to another. The tumbu fly itself is the vector in a loose sense, because the female deposits the eggs in soil or on damp cloth, where the larvae can hatch and attach to human or animal skin. [7]

Diagnostics

Cutaneous myiasis caused by the tumbu fly should be suspected when a patient who has just spent time in Africa tropics presents with ulcers or boil-like sores. Definitive diagnosis is only possible when the larvae are found. They should be removed and allowed to develop into adult flies for identification and examination purposes.

Treatment

When C. anthropophaga causes cutaneous myiasis, the larvae more often than not can be removed without any incision. Covering the punctum (the breathing hole) with petroleum jelly or similar substances cuts off the air supply and forces the maggot to the surface, where it is easy to capture with forceps. If this does not work, local anesthetic can be administered and an incision made to widen the punctum and remove the maggot. [5] Another treatment discussed in the March 2014 Journal of the American Medical Association is to inject a combination of anaesthetic and epinephrine into the insect's chamber. Less drastically, because larvae of C. anthropophaga have smaller hooked bristles on the cuticle than those of Dermatobia hominis , it often is practical just to push on each side of the hole to squeeze the maggot out, especially after first enlarging the punctum. It is important not to burst the larva to prevent the risk of granulomatous or serious inflammatory reaction. [8]

Patients should be monitored for additional and subsequent lesions, as development does not occur in unison and some larvae may take longer to reach the prepupal stage. Antiseptics or antibiotics may be useful to prevent bacterial infection after removal of the larvae, but in practice are not often necessary; the secretions of the larva tend to discourage bacterial growth. As a rule, the wound may be expected to heal readily. [9]

Epidemiology

The tumbu fly is endemic to the tropical regions of Africa, south of the Sahara. Myiasis caused by C. anthropophaga is the most common cause of myiasis in Africa, but can be seen worldwide because of air travel, as human movements carry infestation outside endemic areas. [7]

Public health and prevention strategies

The fly commonly infects humans by laying its eggs on wet clothes, left out to dry. [10] The eggs hatch in one to three days and the larvae (which can survive without a host for up to 15 days) then burrow into the skin when the clothes are worn. [1] A prevention method is to iron all clothes, including underwear, which kills the eggs/larvae. [11] [12]

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<span class="mw-page-title-main">Botfly</span> Parasitic insect

Botflies, also known as warble flies, heel flies, and gadflies, are a family of flies known as the Oestridae. Their larvae are internal parasites of mammals, some species growing in the host's flesh and others within the gut. Dermatobia hominis is the only species of botfly known to parasitize humans routinely, though other species of flies cause myiasis in humans.

<span class="mw-page-title-main">Myiasis</span> Infestation of parasitic maggots

Myiasis, also known as flystrike or fly strike, is the parasitic infestation of the body of a live animal by fly larvae (maggots) that grow inside the host while feeding on its tissue. Although flies are most commonly attracted to open wounds and urine- or feces-soaked fur, some species can create an infestation even on unbroken skin and have been known to use moist soil and non-myiatic flies as vector agents for their parasitic larvae.

<span class="mw-page-title-main">Boil</span> Medical condition (infection)

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<i>Dermatobia hominis</i> Species of fly

The human botfly, Dermatobia hominis, is a species of botfly whose larvae parasitise humans. It is also known as the torsalo or American warble fly, though the warble fly is in the genus Hypoderma and not Dermatobia, and is a parasite on cattle and deer instead of humans.

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<i>Cochliomyia</i> Genus of insects

Cochliomyia is a genus in the family Calliphoridae, known as blowflies, in the order Diptera. Cochliomyia is commonly referred to as the New World screwworm flies, as distinct from Old World screwworm flies. Four species are in this genus: C. macellaria, C. hominivorax, C. aldrichi, and C. minima. C. hominivorax is known as the primary screwworm because its larvae produce myiasis and feed on living tissue. This feeding causes deep, pocket-like lesions in the skin, which can be very damaging to the animal host. C. macellaria is known as the secondary screwworm because its larvae produce myiasis, but feed only on necrotic tissue. Both C. hominivorax and C. macellaria thrive in warm, tropical areas.

<i>Chrysomya rufifacies</i> Species of fly

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Cordylobia is a genus of flies from the family Calliphoridae. The larvae of Cordylobia are parasitic on mammals, especially rodents. Two species, C. anthropophaga and C. rodhaini, also are known as parasites of humans. The adult flies feed on rotting fruits, vegetables, and animal faeces, and are most abundant in the wet season. Like many tropical insects, they are most active in the morning and evening. Cordylobia species are largely confined to Africa, though they have been recorded elsewhere when transported by human travellers.

<i>Ancylostoma braziliense</i> Species of worm

Ancylostoma braziliense is a species of hookworm belonging to the genus Ancylostoma. It is an intestinal parasite of domestic cats and dogs. Severe infection is often fatal to these pets, especially in puppies and kittens. The infection is particularly endemic in the southern United States. It is most often confused with the zoonotic hookworm species Ancylostoma ceylanicum because of their uncanny resemblance.

<i>Chrysomya bezziana</i> Species of fly

Chrysomya bezziana, also known as the Old World screwworm fly or screwworm, is an obligate parasite of mammals. Obligate parasitic flies require a host to complete their development. Named to honor the Italian entomologist Mario Bezzi, this fly is widely distributed in Asia, tropical Africa, India, and Papua New Guinea. The adult can be identified as metallic green or blue with a yellow face and the larvae are smooth, lacking any obvious body processes except on the last segment.

<i>Lucilia cuprina</i> Species of fly

Lucilia cuprina, formerly named Phaenicia cuprina, the Australian sheep blowfly is a blow fly in the family Calliphoridae. It causes the condition known as "sheep strike"'. The female fly locates a sheep with ideal conditions, such as an open wound or a build-up of faeces or urine in the wool, in which she lays her eggs. The emerging larvae cause large lesions on the sheep, which may prove to be fatal.

<i>Oestrus ovis</i> Species of fly

Oestrus ovis, the sheep bot fly, is a widespread species of fly of the genus Oestrus. It is known for its parasitic predation and damage to sheep, deer, goats and sometimes cattle. There have also been many records of horse, dog and human infestation. In some areas of the world it is a significant pest which affects the agricultural economy.

Cordylobia rodhaini, also known as the Lund's fly, derived its common name from captain Lund, who was the first European to show symptoms of the disease caused by the larvae of the same fly. Lund’s fly belongs to the genus Cordylobia, flies from the family Calliphoridae. The larvae of the Lund’s fly are parasites of thinned-skinned mammals, especially the Gambian rat, mona monkey and small antelopes and are only accidental parasites of humans. The adult flies feeds on rotting fruits, vegetables and animal feces, and are most abundant in the wet season. Like many tropical insects they are most active in the dark periods and have the greatest activity early in the morning and late in the evening while resting typically between 8am to 5pm. The Lund’s fly are largely confined to tropical Africa, especially the rainforest areas in Sub-Saharan Africa. As a result of human migration, though, the parasitic infections they cause have been recorded in other continents, including Europe and Asia.

References

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  3. 1 2 Rice, Paul L.; Neva Gleason (January 1972). "Two cases of myiasis in the United States by the African tumbu fly, Cordylobia anthropophaga (Diptera, Calliphoridae)". American Journal of Tropical Medicine and Hygiene. 21 (2): 62–5. doi:10.4269/ajtmh.1972.21.62. PMID   5007189. Archived from the original on 2013-02-24. Retrieved 2009-03-17.
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