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Early rule Conquest of the Persian Empire Expedition into India Death and legacy Cultural impact | ||
The death of Alexander the Great and subsequent related events have been the subjects of debates. According to a Babylonian astronomical diary, Alexander died in the palace of Nebuchadnezzar II in Babylon between the evening of 10 June and the evening of 11 June 323 BC, [1] at the age of 32.
Macedonians and local residents wept at the news of the death, while Achaemenid subjects were forced to shave their heads. [2] The mother of Darius III, Sisygambis, having learned of Alexander's death, became depressed and killed herself later. [3] Historians vary in their assessments of primary sources about Alexander's death, which has resulted in different views about its cause and circumstances.
In February 323 BC, Alexander ordered his armies to prepare for the march to Babylon. [4] According to Arrian, after crossing the Tigris Alexander was met by Chaldeans, who advised him not to enter the city because their deity Bel had warned them that to do so at that time would be fatal for Alexander. [5] The Chaldeans also warned Alexander against marching westwards as he would then look to the setting sun, a symbol of decline. [5] It was suggested that he enter Babylon via the Royal Gate, in the western wall, where he would face to the east. Alexander followed this advice, but the route turned out to be unfavorable because of swampy terrain. [5] According to Jona Lendering, "it seems that in May 323" the Babylonian astrologers tried to avert the misfortune by substituting Alexander with an ordinary person on the Babylonian throne, who would take the brunt of the omen. [4] The Greeks, however, did not understand that ritual. [4]
Calanus was likely to be a Hindu Naga sadhu, whom Greeks called gymnosophists. He had accompanied the Greek army back from Punjab, upon request by Alexander. He was 73 years of age at that time. However, when Persian weather and travel fatigue weakened him, he informed Alexander that he would rather die than live disabled. He decided to take his life by self-immolation. Alexander tried to dissuade him from doing so but upon the insistence of Calanus, Alexander relented and the job of building a pyre was entrusted to Ptolemy. [6] The place where this incident took place was Susa in 323 BC. [7] Calanus is mentioned also by Alexander's admiral, Nearchus and Chares of Mytilene. [8] He did not flinch as he burnt to the astonishment of those who watched. [9] [10] Before immolating himself alive on the pyre, his last words to Alexander were "We shall meet in Babylon". [11] [12] Thus he is said to have prophesied the death of Alexander in Babylon. At the time of the death of Calanus, Alexander, however, did not have any plan to go to Babylon. [12] [13] No one understood the meaning of his words "We shall meet in Babylon". It was only after Alexander fell sick and died in Babylon, that the Greeks came to realize what Calanus intended to convey.
According to historical accounts, Alexander's body began to decompose six days after his death. Proposed causes of Alexander's death include alcoholic liver disease, fever, and strychnine poisoning, but little data support those versions. [14] According to the University of Maryland School of Medicine report of 1998, Alexander probably died of typhoid fever [15] (which, along with malaria, was common in ancient Babylon). [16] In the week before his death, historical accounts mention chills, sweats, exhaustion and high fever, typical symptoms of infectious diseases, including typhoid fever. [15] According to David W. Oldach from the University of Maryland Medical Center, Alexander also had "severe abdominal pain, causing him to cry out in agony". [15] The associated account, however, comes from the unreliable Alexander Romance . According to Andrew N. Williams and Robert Arnott, in his last days Alexander was unable to speak, which was due to a previous injury to his neck during the Siege of Cyropolis. [17]
Other popular theories contend that Alexander either died of malaria or was poisoned. Other retrodiagnoses include noninfectious diseases as well. [18] According to author Andrew Chugg, there is evidence Alexander died of malaria, having contracted it two weeks before the onset of illness while sailing in the marshes to inspect flood defences. Chugg based his argument [19] on the Ephemerides (Journal) compiled by Alexander's secretary, Eumenes of Cardia. [20] Chugg also showed in a paper in the Ancient History Bulletin [21] that the Ephemerides are probably authentic. Chugg further noted that Arrian states that Alexander "No longer had any rest from the fever" halfway through his fatal illness. [22] This is evidence that the fever had initially been intermittent, which is the signature fever curve of Plasmodium falciparum (the expected malarial parasite, given Alexander's travel history and the severity of the illness), thus enhancing the likelihood of malaria. [23] The malaria version was also supported by Paul Cartledge.[ citation needed ]
Throughout the centuries suspicions of possible poisoning have fallen on a number of alleged perpetrators, including one of Alexander's wives, his generals, his illegitimate half-brother or the royal cup-bearer. [24] The poisoning version is featured particularly in the politically motivated Liber de Morte Testamentoque Alexandri (The Book On the Death and Testament of Alexander), which tries to discredit the family of Antipater. It was argued that the book was compiled in Polyperchon's circle, not before c. 317 BC. [25] This theory was also advanced by Justin in his Historia Philippicae et Totius Mundi Origines et Terrae Situs where he stated that Antipater murdered Alexander by feeding him a poison so strong that it "could be conveyed [only] in the hoof of a horse.". [26]
In Alexander the Great: The Death of a God, Paul C. Doherty claimed that Alexander was poisoned with arsenic by his possibly illegitimate half-brother Ptolemy I Soter. [24] However, this was disputed by New Zealand National Poisons Centre toxicologist Dr. Leo Schep, who discounted arsenic poisoning and instead suggested that he could have been poisoned by a wine made from the plant Veratrum album , known as white hellebore. [27] This poisonous plant can produce prolonged poisoning symptoms that match the course of events as described in the Alexander Romance, and was known to the Ancient Greeks. The article was published in the peer-reviewed medical journal Clinical Toxicology and suggested that if Alexander was poisoned, Veratrum album offers the most plausible cause. [27] [28] This theory is supported by the writings of the Ancient Greek historian Diodorus, who had recorded Alexander becoming "stricken with pain after drinking a large bowl of wine" [29] at a banquet hosted by one of his officers, Medius of Larissa. However, historian Robin Lane Fox has argued that allegations of poisoning are "technically implasuible" [6] given the length of time between Alexander's first reported symptoms and his death. "The poisons of herbalists were swift and irremediable, whether hemlocks, hellebores or belladonnas, and except as an explanation of mysterious illness, a slow poison met no need in the poison-chests of ancient Greece. If Alexander had been poisoned, he should surely have been given a massive dose which was absolutely certain to kill him at once. And yet Diaries, pamphlets and official calendars insist that twelve days elapsed between Medius's fateful banquet and the death of the king." [6]
Epidemiologist John Marr and Charles Calisher put forward the West Nile fever as the possible cause of Alexander's death. This version was deemed "fairly compelling" by University of Rhode Island epidemiologist Thomas Mather, who nonetheless noted that the West Nile virus tends to kill the elderly or those with weakened immune systems. [30] The version of Marr and Calisher was also criticized by Burke A. Cunha from Winthrop University Hospital. [31] According to analysis of other authors in response to Marr and Calisher, the West Nile virus could not have infected humans before the 8th century AD. [31]
Other causes that have been put forward include acute pancreatitis provoked by "heavy alcohol consumption and a very rich meal", [32] acute endocarditis, [16] schistosomiasis brought on by Schistosoma haematobium , [16] porphyria, [16] and Guillain-Barré syndrome. [33] Fritz Schachermeyr proposed leukemia and malaria. When Alexander's symptoms were entered into databases of the Global Infectious Disease Epidemiology Network, influenza gained the highest probability (41.2%) on the list of differential diagnoses. [18] However, according to Cunha, the symptoms and course of Alexander's disease are inconsistent with influenza, as well as with malaria, schistosomiasis, and poisoning in particular. [14]
Another theory moves away from disease and hypothesizes that Alexander's death was related to a congenital scoliotic syndrome. [34] It has been discussed that Alexander had structural neck deformities and oculomotor deficits, [35] which could be associated with Klippel–Feil syndrome, a rare congenital scoliotic disorder. [36] His physical deformities and symptoms leading up to his death are what lead experts to believe this. Some believe that as Alexander fell ill in his final days, he suffered from progressive epidural spinal cord compression, which left him quadriplegic. [37] However, this hypothesis cannot be proven without a full analysis of Alexander's body. [36]
Some have speculated that he suffered from Guillain-Barré syndrome, which typhoid fever can lead to when complicated with other maladies. He may have contracted this disease from a Helicobacter pylori infection after his lung wound during the siege of Multan, where it was common at the time. [38] [39] Proponents say this would explain why Alexander's body reportedly did not decompose for 6 days following his 'death' as he may well have been still alive but in a deep coma. [40]
One ancient account reports that the planning and construction of an appropriate funerary cart to convey the body out from Babylon took two years from the time of Alexander's death. [41] It is not known exactly how the body was preserved for about two years before it was moved from Babylon. In 1889, E. A. Wallis Budge suggested that the body was submerged in a vat of honey, [42] while Plutarch reported treatment by Egyptian embalmers. [41]
Egyptian and Chaldean embalmers who arrived on 16 June are said to have attested to Alexander's lifelike appearance. [3] This was interpreted as a complication of typhoid fever, known as ascending paralysis, which causes a person to appear dead prior to death. [15]
On its way back to Macedonia, the funerary cart with Alexander's body was met in Syria by one of Alexander's generals, the future ruler Ptolemy I Soter. In late 322 or early 321 BC Ptolemy diverted the body to Egypt where it was interred in Memphis. In the late 4th or early 3rd century BC Alexander's body was transferred from the Memphis tomb to Alexandria for reburial [41] (by Ptolemy Philadelphus in c. 280 BC, according to Pausanias). Later Ptolemy Philopator placed Alexander's body in Alexandria's communal mausoleum. [41] Shortly after the death of Cleopatra, Alexander's tomb was visited by Augustus, who is said to have placed flowers on the tomb and a golden diadem upon Alexander's head. [41] By the 4th century AD, the location of Alexander's body was no longer known; later authors, such as Ibn Abd al-Hakam, Al-Masudi and Leo Africanus, report having seen Alexander's tomb. [41] Leo Africanus in 1491 and George Sandys in 1611 reportedly saw the tomb in Alexandria. [43] According to one legend, the body lies in a crypt beneath an early Christian church. [44]
Alexander III of Macedon, most commonly known as Alexander the Great, was a king of the ancient Greek kingdom of Macedon. He succeeded his father Philip II to the throne in 336 BC at the age of 20 and spent most of his ruling years conducting a lengthy military campaign throughout Western Asia, Central Asia, parts of South Asia, and Egypt. By the age of 30, he had created one of the largest empires in history, stretching from Greece to northwestern India. He was undefeated in battle and is widely considered to be one of history's greatest and most successful military commanders.
Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called SalmonellaTyphi. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several days. This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting. Some people develop a skin rash with rose colored spots. In severe cases, people may experience confusion. Without treatment, symptoms may last weeks or months. Diarrhea may be severe, but is uncommon. Other people may carry it without being affected, but are still contagious. Typhoid fever is a type of enteric fever, along with paratyphoid fever. Salmonella enterica Typhi is believed to infect and replicate only within humans.
Fever or pyrexia in humans is a symptom of an anti-infection defense mechanism that appears with body temperature exceeding the normal range due to an increase in the body's temperature set point in the hypothalamus. There is no single agreed-upon upper limit for normal temperature: sources use values ranging between 37.2 and 38.3 °C in humans.
This article concerns the period 329 BC – 320 BC.
Ptolemy I Soter was a Macedonian Greek general, historian, and successor of Alexander the Great who went on to found the Ptolemaic Kingdom centered on Egypt. Ptolemy was basileus and pharaoh of Ptolemaic Egypt from 305/304 BC to his death in 282 BC, and his descendants continued to rule Egypt until 30 BC. During their rule, Egypt became a thriving bastion of Hellenistic civilization and Alexandria a great seat of Greek culture.
Seleucus I Nicator was a Macedonian Greek general, officer and successor of Alexander the Great who went on to found the eponymous Seleucid Empire, led by the Seleucid dynasty. Initially a secondary player in the power struggles following Alexander's death, Seleucus rose to become the total ruler of Asia Minor, Syria, Mesopotamia, and the Iranian plateau, assuming the title of basileus (king). The Seleucid Empire was one of the major powers of the Hellenistic world, until it was overcome by the Roman Republic and Parthian Empire in the late second and early first centuries BC.
Alexander IV, sometimes erroneously called Aegus in modern times, was the posthumous son of Alexander the Great by his wife Roxana of Bactria. As his father's only surviving legitimate child, Alexander IV inherited the throne of the Macedonian Empire after him, however he was murdered in his early teens, never wielding actual power.
Hephaestion, son of Amyntor, was an ancient Macedonian nobleman of probable "Attic or Ionian extraction" and a general in the army of Alexander the Great. He was "by far the dearest of all the king's friends; he had been brought up with Alexander and shared all his secrets." This relationship lasted throughout their lives, and was compared, by others as well as themselves, to that of Achilles and Patroclus.
Dinocrates of Rhodes was a Greek architect and technical adviser for Alexander the Great. He is known for his plan for the city of Alexandria, the monumental funeral pyre for Hephaestion and the reconstruction of the Temple of Artemis at Ephesus, as well as other works.
Nectanebo II was the last native ruler of ancient Egypt, as well as the third and last pharaoh of the Thirtieth Dynasty, reigning from 358 to 340 BC.
The Plague of Athens was an epidemic that devastated the city-state of Athens in ancient Greece during the second year of the Peloponnesian War when an Athenian victory still seemed within reach. The plague killed an estimated 75,000 to 100,000 people, around 25% of the population, and is believed to have entered Athens through Piraeus, the city's port and sole source of food and supplies. Thucydides, an Athenian survivor, wrote that much of the eastern Mediterranean also saw an outbreak of the disease, albeit with less impact.
Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of three types of Salmonella enterica. Symptoms usually begin 6–30 days after exposure and are the same as those of typhoid fever. Often, a gradual onset of a high fever occurs over several days. Weakness, loss of appetite, and headaches also commonly occur. Some people develop a skin rash with rose-colored spots. Without treatment, symptoms may last weeks or months. Other people may carry the bacteria without being affected; however, they are still able to spread the disease to others. Typhoid and paratyphoid are of similar severity. Paratyphoid and typhoid fever are types of enteric fever.
Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure.
Human parasites include various protozoa and worms.
Mosquito-borne diseases or mosquito-borne illnesses are diseases caused by bacteria, viruses or parasites transmitted by mosquitoes. Nearly 700 million people contract mosquito-borne illnesses each year, resulting in more than a million deaths.
The tomb of Alexander the Great is attested in several historical accounts, but its current exact location remains an enduring mystery. Following Alexander's death in Babylon, his body was initially buried in Memphis by one of his generals, Ptolemy I Soter, before being transferred to Alexandria, where it was reburied. Julius Caesar, Cleopatra and Augustus, among others, are noted as having visited Alexander's tomb in Alexandria in antiquity. Its later fate is unknown, and it had possibly been destroyed by the 4th or 5th centuries; since the 19th century, over one hundred official attempts have been made to try to identify the site of Alexander's tomb in Alexandria.
Kalanos, also spelled Calanus, was an ancient Indian gymnosophist and philosopher from Taxila who accompanied Alexander the Great to Persis and later self-immolated, after falling ill, entered himself into a pyre, in front of Alexander and his army. Diodorus Siculus called him Caranus.
John S. Marr is an American physician, epidemiologist, and author. His professional life has concerned outbreaks of infectious disease and thus his subsequent writing career has focused on that topic, particularly historical epidemics.
The Ptolemaic cult of Alexander the Great was an imperial cult in ancient Egypt during the Hellenistic period, promoted by the Ptolemaic dynasty. The core of the cult was the worship of the deified conqueror-king Alexander the Great, which eventually formed the basis for the ruler cult of the Ptolemies themselves. The head priest of the imperial cult was the chief priest in the Ptolemaic Kingdom.
The malaria therapy is an archaic medical procedure of treating diseases using artificial injection of malaria parasites. It is a type of pyrotherapy by which high fever is induced to stop or eliminate symptoms of certain diseases. In malaria therapy, malarial parasites (Plasmodium) are specifically used to cause fever, and an elevated body temperature reduces the symptoms of or cure the diseases. As the primary disease is treated, the malaria is then cured using antimalarial drugs. The method was developed by Austrian physician Julius Wagner-Jauregg in 1917 for the treatment of neurosyphilis for which he received the 1927 Nobel Prize in Physiology or Medicine.