FKBP10

FKBP10
Identifiers
Aliases	FKBP10 , FKBP65, OI11, OI6, PPIASE, hFKBP65, BRKS1, FK506 binding protein 10, FKBP prolyl isomerase 10
External IDs	OMIM: 607063 MGI: 104769 HomoloGene: 7718 GeneCards: FKBP10
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 41,812,680 bp [1] End 41,823,213 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 63.47 cM Start 100,306,523 bp [2] End 100,315,650 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ascending aorta anterior pituitary right coronary artery canal of the cervix left coronary artery left uterine tube gallbladder Right adrenal gland smooth muscle tissue Top expressed in calvaria internal carotid artery external carotid artery body of femur fossa molar vas deferens dermis condyle ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding isomerase activity peptidyl-prolyl cis-trans isomerase activity metal ion binding FK506 binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum cytoplasm nucleolus Biological process chaperone-mediated protein folding histone peptidyl-prolyl isomerization peptidyl-proline modification protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60681 14230 Ensembl ENSG00000141756 ENSMUSG00000001555 UniProt Q96AY3 Q61576 RefSeq (mRNA) NM_021939 NM_001163481 NM_010221 RefSeq (protein) NP_068758 NP_001156953 NP_034351 Location (UCSC) Chr 17: 41.81 – 41.82 Mb Chr 11: 100.31 – 100.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene. ^{[5] [6] [7]}

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141756 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001555 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Patterson CE, Schaub T, Coleman EJ, Davis EC (Feb 2001). "Developmental Regulation of FKBP65: An ER-localized Extracellular Matrix Binding-Protein". Mol Biol Cell. 11 (11): 3925–35. doi:10.1091/mbc.11.11.3925. PMC   15047 . PMID   11071917.
6. Ishikawa Y, Vranka J, Wirz J, Nagata K, Bachinger HP (Nov 2008). "The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens". J Biol Chem. 283 (46): 31584–90. doi: 10.1074/jbc.M802535200 . PMID   18786928.
7. "Entrez Gene: FKBP10 FK506 binding protein 10, 65 kDa".

Further reading

• Patterson CE, Gao J, Rooney AP, Davis EC (2002). "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family". Genomics. 79 (6): 881–9. doi:10.1006/geno.2002.6777. PMID   12036304.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID   12754519. S2CID   581283.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID   16396496.