Geranylgeranylglycerol-phosphate geranylgeranyltransferase

geranylgeranylglycerol-phosphate geranylgeranyltransferase
Identifiers
EC no.	2.5.1.42
CAS no.	124650-68-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase (EC 2.5.1.42) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl groups or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6U and 2F6X.

References

• Zhang DL, Daniels L, Poulter CD (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112 (3): 1264–1265. doi:10.1021/ja00159a067.