Dimethylallyltranstransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.1 | ||||||||
CAS no. | 9032-79-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | |||||||
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Identifiers | |||||||
Symbol | FDPS | ||||||
NCBI gene | 2224 | ||||||
HGNC | 3631 | ||||||
OMIM | 134629 | ||||||
RefSeq | NM_002004 | ||||||
UniProt | P14324 | ||||||
Other data | |||||||
EC number | 2.5.1.1 | ||||||
Locus | Chr. 1 q22 | ||||||
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Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP). [5] [6]
Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.
Phosphomevalonate kinase is an enzyme in the mevalonate pathway that in humans is encoded by the PMVK gene.
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.
Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.
Probable G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.
ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.
Decaprenyl-diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene.
Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.
Geranylgeranyl pyrophosphate synthase is an enzyme that in humans is encoded by the GGPS1 gene.
CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.
ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.
Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.
CYP4A22 also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.
ATP synthase mitochondrial F1 complex assembly factor 1, also known as ATP11 homolog, is a protein that in humans is encoded by the ATPAF1 gene.
4-Hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) also known as dihydrodipicolinate synthase-like (DHDPSL) is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from hydroxyproline. Glyoxylate is catabolised to oxalate, resulting in excess excretion of oxalate in urine, predisposing to oxalate stone; a condition known as primary hyperoxaluria type III.
Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) is an enzyme in humans that is encoded by the HMGCS2 gene.
Ceramide synthase 6 is a protein that in humans is encoded by the CERS6 gene.
Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.
Tetraspanin 14 is a protein that in humans is encoded by the TSPAN14 gene.