Dimethylallyltranstransferase

Last updated
FDPS
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FDPS , FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDs OMIM: 134629 MGI: 104888 HomoloGene: 1519 GeneCards: FDPS
EC number 2.5.1.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253751
NM_134469
NM_180985

RefSeq (protein)

NP_001240680
NP_608219

Location (UCSC) Chr 1: 155.31 – 155.32 Mb Chr 3: 89 – 89.01 Mb
PubMed search [3] [4]
Wikidata
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Dimethylallyltranstransferase
2f8z.jpg
Identifiers
EC no. 2.5.1.1
CAS no. 9032-79-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins
Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
SymbolFDPS
NCBI gene 2224
HGNC 3631
OMIM 134629
RefSeq NM_002004
UniProt P14324
Other data
EC number 2.5.1.1
Locus Chr. 1 q22
Search for
Structures Swiss-model
Domains InterPro

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP). [5] [6]

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160752 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059743 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.
  6. Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID   736921.