Glycolaldehyde dehydrogenase

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glycolaldehyde dehydrogenase
Identifiers
EC no. 1.2.1.21
CAS no. 37250-89-8
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BRENDA BRENDA entry
ExPASy NiceZyme view
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MetaCyc metabolic pathway
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In enzymology, a glycolaldehyde dehydrogenase (EC 1.2.1.21) is an enzyme that catalyzes the chemical reaction

glycolaldehyde + NAD+ + H2O glycolate + NADH + H+

The 3 substrates of this enzyme are glycolaldehyde, NAD+, and H2O, whereas its 3 products are glycolate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HG2, 2ILU, and 2IMP.

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References


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