Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. [5] [6] [7]
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM] [7]
HDAC10 has been shown to interact with Histone deacetylase 2 [8] and Nuclear receptor co-repressor 2. [8]
Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones. As such, it plays an important role in gene expression by facilitating the formation of transcription repressor complexes and for this reason is often considered an important target for cancer therapy.
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.
Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.
Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.
Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.
Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders.
Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.
Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.
DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.
Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene.
General transcription factor II-I repeat domain-containing protein 1 is a protein that in humans is encoded by the GTF2IRD1 gene.
Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AM gene.
Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.
Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.
Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene.
Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.
THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.