HDAC10

HDAC10
Identifiers
Aliases	HDAC10 , HD10, histone deacetylase 10
External IDs	OMIM: 608544 MGI: 2158340 HomoloGene: 23749 GeneCards: HDAC10
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.33 Start 50,245,183 bp [1] End 50,251,405 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E3 Start 89,007,510 bp [2] End 89,012,903 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary spleen canal of the cervix body of stomach minor salivary gland skin of abdomen right lobe of thyroid gland right lobe of liver left lobe of thyroid gland Top expressed in esophagus lip proximal tubule lacrimal gland neural tube thymus spleen morula superior frontal gyrus autonomic nervous system More reference expression data BioGPS n/a
Gene ontology Molecular function NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding protein binding enzyme binding hydrolase activity histone deacetylase activity zinc ion binding deacetylase activity acetylputrescine deacetylase activity acetylspermidine deacetylase activity metal ion binding Cellular component cytoplasm histone deacetylase complex nucleoplasm nucleus Biological process histone H3 deacetylation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated protein deacetylation oligodendrocyte development negative regulation of transcription, DNA-templated histone deacetylation chromatin organization macroautophagy positive regulation of mismatch repair peptidyl-lysine deacetylation homologous recombination polyamine deacetylation spermidine deacetylation DNA repair DNA recombination autophagy cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83933 170787 Ensembl ENSG00000100429 ENSMUSG00000062906 UniProt Q969S8 Q08AP5 Q6P3E7 RefSeq (mRNA) NM_032019 NM_001159286 NM_199198 RefSeq (protein) NP_001152758 NP_114408 NP_954668 Location (UCSC) Chr 22: 50.25 – 50.25 Mb Chr 15: 89.01 – 89.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. ^{[5] [6] [7]}

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM] ^[7]

Interactions

HDAC10 has been shown to interact with Histone deacetylase 2 ^[8] and Nuclear receptor co-repressor 2. ^[8]

See also

• Histone deacetylase

References

1. GRCh38: Ensembl release 89: ENSG00000100429 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062906 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem. 277 (1): 187–93. doi: 10.1074/jbc.M108931200 . PMID   11677242.
6. Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem. 277 (5): 3350–6. doi: 10.1074/jbc.M109861200 . PMID   11726666.
7. "Entrez Gene: HDAC10 histone deacetylase 10".
8. Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. United States. 277 (8): 6656–66. doi: 10.1074/jbc.M108055200 . ISSN   0021-9258. PMID   11739383.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Fischer DD, Cai R, Bhatia U, et al. (2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. 277 (8): 6656–66. doi: 10.1074/jbc.M108055200 . PMID   11739383.
• Tong JJ, Liu J, Bertos NR, Yang XJ (2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Res. 30 (5): 1114–23. doi:10.1093/nar/30.5.1114. PMC   101247 . PMID   11861901.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi: 10.1074/jbc.C300407200 . PMID   14578343.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Osada H, Tatematsu Y, Saito H, et al. (2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". Int. J. Cancer. 112 (1): 26–32. doi: 10.1002/ijc.20395 . PMID   15305372. S2CID   23452893.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• HDAC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.