HLA-DPB1

HLA-DPB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M
Identifiers
Aliases	HLA-DPB1 , DPB1, HLA-DP, HLA-DP1B, HLA-DPB, major histocompatibility complex, class II, DP beta 1
External IDs	OMIM: 142858 HomoloGene: 129927 GeneCards: HLA-DPB1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,089,696 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; monocyte; ; gallbladder; ; spleen; ; upper lobe of left lung; ; right lung; ; duodenum; ; right coronary artery; ; rectum;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding ;
Cellular component	integral component of membrane ; endocytic vesicle membrane ; clathrin-coated endocytic vesicle membrane ; endosome ; Golgi apparatus ; trans-Golgi network membrane ; endoplasmic reticulum membrane ; membrane ; Golgi membrane ; plasma membrane ; transport vesicle membrane ; MHC class II protein complex ; cell surface ; lysosomal membrane ; endoplasmic reticulum ; ER to Golgi transport vesicle membrane ; lysosome ; integral component of lumenal side of endoplasmic reticulum membrane ; endosome membrane ;
Biological process	antigen processing and presentation ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; interferon-gamma-mediated signaling pathway ; immune system process ; T cell costimulation ; positive regulation of interferon-gamma production ; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ; positive regulation of T cell activation ; positive regulation of T cell proliferation ; immune response ; T cell receptor signaling pathway ; adaptive immune response ;
	Sources:Amigo / QuickGO
Orthologs
	3115
	n/a
ENSG00000236693 ; ENSG00000230708 ; ENSG00000229295 ; ENSG00000226826 ; ENSG00000215048 ;
	ENSG00000223865 ; ENSG00000230763 ; ENSG00000237710
	n/a
	P04440
	n/a
	NM_002121
	n/a
	NP_002112
	n/a
	Wikidata
View/Edit Human

Last updated April 02, 2024

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.^[3]

Related Research Articles

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<span class="mw-page-title-main">Major histocompatibility complex, class II, DQ alpha 1</span> Protein-coding gene in the species Homo sapiens

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References

1 2 3 ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 GRCh38: Ensembl release 89: ENSG00000236693, ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".

Mitsunaga S, Kuwata S, Tokunaga K, Uchikawa C, Takahashi K, Akaza T, Mitomi Y, Juji T (1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): 203–11. doi:10.1016/0198-8859(92)90113-2. PMID 1358867.
Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229–43. doi:10.1111/j.1399-0039.1992.tb02050.x. PMID 1362295.
Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108–10. doi:10.1111/j.1399-0039.1992.tb01969.x. PMID 1412416.
Korioth F, Hartung K, Deicher H, Frey J (1992). "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus". Tissue Antigens. 39 (4): 216–9. doi:10.1111/j.1399-0039.1992.tb01938.x. PMID 1529429.
de Koster HS, Kenter MJ, D'Amaro J, Luiten RM, Schroeijers WE, Giphart MJ, Termijtelen A (1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics. 34 (1): 12–22. doi:10.1007/BF00212307. PMID 1713190. S2CID 21845822.
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Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi: 10.4049/jimmunol.144.2.526 . PMID 1967269.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi: 10.1073/pnas.87.22.9052 . PMC 55099 . PMID 1978941.
Bugawan TL, Begovich AB, Erlich HA (1990). "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes". Immunogenetics. 32 (4): 231–41. doi:10.1007/BF00187094. PMID 2242906. S2CID 39873046.
Lair B, Alber C, Yu WY, Watts R, Bahl M, Karr RW (1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. Immunol. 141 (4): 1353–7. doi: 10.4049/jimmunol.141.4.1353 . PMID 2456351.
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Begovich AB, Bugawan TL, Nepom BS, Klitz W, Nepom GT, Erlich HA (1990). "A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9489–93. doi: 10.1073/pnas.86.23.9489 . PMC 298522 . PMID 2512583.
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[refGRCh38Ensembl-1] 1 2 3 ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 GRCh38: Ensembl release 89: ENSG00000236693, ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".

[1]

[2]

[3]

v t e Major histocompatibility complex classes
MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G
MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5
Other	Human leukocyte antigen Minor histocompatibility antigen Blood transfusion Arrestin Calgranulin Human blood group systems Cell adhesion molecules Cluster of differentiation

HLA-DPB1

Contents

See also

Related Research Articles

References

Further reading