L-olivosyl-oleandolide 3-O-methyltransferase

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L-olivosyl-oleandolide 3-O-methyltransferase
Identifiers
EC no. 2.1.1.239
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L-olivosyl-oleandolide 3-O-methyltransferase (EC 2.1.1.239, OleY) is an enzyme with systematic name S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase. [1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + L-olivosyl-oleandolide S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide

The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus .

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References

  1. ↑ Rodríguez L, Rodríguez D, Olano C, Braña AF, Méndez C, Salas JA (September 2001). "Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus". Journal of Bacteriology. 183 (18): 5358–63. doi:10.1128/jb.183.18.5358-5363.2001. PMC   95419 . PMID   11514520.
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