It is advised to check the references for photos of reaction results. [1] Reagent testers might show the colour of the desired substance while not showing a different colour for a more dangerous additive. [2] For this reason it is essential to use multiple different tests to show all adulterants.
Substance | Type | A Folin's B | Froehde | Liebermann | Mandelin |
---|---|---|---|---|---|
2C-B [1] | Substance | ? | Yellow [3] | Yellow > Black [4] | No reaction |
2C-E | Substance | ? | ? | ? | ? |
2C-I [1] | Substance | ? | ? | ? | No reaction |
2C-T-2 | Substance | ? | ? | ? | ? |
2C-T-7 | Substance | ? | Violet and orange streaks [5] | ? | Maroon to Black |
4-MEC | Substance | ? | ? | ? | ? |
Acetaminophen | Adulterant | ? | No reaction [3] | ? | Moderate olive [6] |
Alcohol | Substance | ? | ? | ? | ? |
Alkaloids | Forms | ? | ? | ? | ? |
Amines, and amino acids | Forms | ? | ? | ? | ? |
Amphetamine | Substance | ? | Red | ? | Moderate bluish green [6] |
Asbestos (talc) | Adulterant | ? | ? | ? | ? |
Aspirin | Adulterant | ? | Grayish purple [6] | ? | Grayish olive green [6] |
Barbiturates | Class | ? | ? | ? | ? |
Benzocaine | Adulterant | ? | ? | ? | ? |
Benzodiazepines | Class | ? | ? | ? | ? |
Benzphetamine | Substance | ? | ? | ? | Brilliant yellow green |
Boric acid | Adulterant | ? | ? | ? | ? |
Brodifacoum (pesticide) | Adulterant | ? | ? | ? | ? |
Caffeine | Substance | ? | No reaction | ? | No reaction |
CBD | Substance | ? | ? | ? | ? |
Chloral hydrate | Substance | ? | ? | ? | ? |
Chloroquine | Adulterant | ? | ? | ? | ? |
Chlorpromazine | Substance | ? | Very deep red [7] [6] | ? | Dark olive |
Cocaine | Substance | ? | No reaction [3] | ? | Deep orange yellow [6] |
Codeine | Substance | ? | Dark Green [7] [8] > Red/Brown [9] [6] | ? | Dark olive [6] |
Creatine | Adulterant | ? | ? | ? | ? |
Diacetylmorphine (Heroin) | Substance | ? | Purple/red > to green [3] | ? | Moderate reddish brown |
Diltiazem | Adulterant | ? | ? | ? | ? |
Dimethoxy-meth | Substance | ? | ? | ? | Dark olive brown |
Dimethylterephthalate | Adulterant | ? | ? | ? | ? |
DMT | Substance | ? | ? | ? | ? |
DOM | Substance | ? | ? | ? | ? |
Doxepin | Substance | ? | Deep reddish brown [7] | ? | Very reddish brown |
Dristan | Substance | ? | Light bluish green [7] [6] | ? | Greyish olive |
DXM | Substance | ? | No reaction | ? | White w/ green edges [10] |
Fentanyl | Substance | ? | ? | ? | ? |
Formaldehyde | Adulterant | ? | ? | ? | ? |
GHB | Substance | ? | ? | ? | ? |
Hydrochlorides | Forms | ? | ? | ? | ? |
Hydroxyzine | Adulterant | ? | ? | ? | ? |
Indoles | Forms | ? | ? | ? | ? |
Isopropylbenzylamine | Adulterant | ? | ? | ? | ? |
Ketamine | Substance | ? | No reaction [3] | ? | Orange/brown |
Levamisole | Adulterant | ? | ? | ? | ? |
Lidocaine | Adulterant | ? | ? | ? | ? |
LSD | Substance | ? | Moderate yellow green [6] | ? | ? |
Mace | Substance | ? | Light olive yellow [7] [6] | ? | Moderate olive green [6] |
Mannitol | Adulterant | ? | ? | ? | ? |
MDA | Substance | ? | Greenish black [3] [7] [6] | ? | Bluish black [11] [6] |
MDEA | Substance | ? | ? | ? | Dark purple |
MDMA | Substance | ? | Black w/ hints of greenish brown [3] | ? | Bluish black [11] |
Mephedrone | Substance | ? | No reaction | ? | No reaction |
Mescaline | Substance | ? | Green > to Blue [9] or Yellow [12] | ? | Dark yellowish brown [6] |
Methadone | Substance | ? | ? | ? | Dark greyish blue |
Methamphetamine | Substance | ? | No reaction [5] | ? | Dark yellowish green [6] |
Methaqualone | Substance | ? | ? | ? | Very orange yellow [6] |
Methoxetamine | Substance | ? | Yellow to green | ? | No reaction |
Methylone [1] | Substance | ? | Deep green [13] | ? | Yellow |
Methylphenidate | Substance | ? | No reaction [7] | ? | Brilliant orange yellow |
Methylsulfonylmethane | Adulterant | ? | ? | ? | ? |
MXE | Substance | ? | ? | ? | ? |
Nutmeg | Adulterant | ? | ? | ? | ? |
Opiates | Class | ? | ? | ? | ? |
Synthetic opioids (gray death) | Class | ? | ? | ? | ? |
PCP | Substance | ? | ? | ? | ? |
Phenacetin | Adulterant | ? | ? | ? | ? |
Phytocannabinoids | Class | ? | ? | ? | ? |
PMA | Substance | ? | n [3] | ? | Green to brown |
Primary amines | Forms | ? | ? | ? | ? |
Procaine | Adulterant | ? | ? | ? | Deep orange [6] |
Psilocybin | Substance | ? | ? | ? | ? |
Quinine | Adulterant | ? | ? | ? | Deep greenish yellow [6] |
Reducing sugars (sugar) | Adulterant | No reaction | White > light brown | White w/ light purple edges | White > brown |
Secondary amines | Forms | ? | ? | ? | ? |
Sodium bicarbonate | Adulterant | ? | ? | ? | ? |
Strychnine | Adulterant | ? | ? | ? | ? |
Sulfates | Forms | ? | ? | ? | ? |
Synthetic cannabinoids | Class | ? | ? | ? | ? |
THC | Substance | ? | ? | ? | ? |
Tocopheryl acetate | Adulterant | ? | ? | ? | ? |
Tramadol | Substance | ? | ? | ? | ? |
Substance | Type | Marquis | Mecke | A Morris B | A Simon's B |
---|---|---|---|---|---|
2C-B [1] | Substance | Yellow to green [5] [3] | Yellow/brown | ? | No reaction |
2C-E | Substance | ? | ? | ? | ? |
2C-I [1] | Substance | Yellow to green | Dark brown | ? | No reaction |
2C-T-2 | Substance | ? | ? | ? | ? |
2C-T-7 | Substance | Apricot | Red to purple | ? | No reaction |
4-MEC | Substance | No reaction [5] | Light green | ? | ? |
Acetaminophen | Adulterant | ? | ? | ? | ? |
Alcohol | Substance | ? | ? | ? | ? |
Alkaloids | Forms | ? | ? | ? | ? |
Amines, and amino acids | Forms | ? | ? | ? | ? |
Amphetamine | Substance | Strong reddish orange/Dark reddish brown [6] | No reaction | ? | No reaction |
Asbestos (talc) | Adulterant | ? | ? | ? | ? |
Aspirin | Adulterant | Deep red [6] | ? | ? | ? |
Barbiturates | Class | ? | ? | ? | ? |
Benzocaine | Adulterant | ? | ? | ? | ? |
Benzodiazepines | Class | ? | ? | ? | ? |
Benzphetamine | Substance | Deep reddish brown [6] | ? | ? | ? |
Boric acid | Adulterant | ? | ? | ? | ? |
Brodifacoum (pesticide) | Adulterant | ? | ? | ? | ? |
Caffeine | Substance | No reaction | No reaction | ? | No reaction |
CBD | Substance | ? | ? | ? | ? |
Chloral hydrate | Substance | ? | ? | ? | ? |
Chloroquine | Adulterant | ? | ? | ? | ? |
Chlorpromazine | Substance | Deep purplish red [6] | Blackish red [6] | ? | ? |
Cocaine | Substance | No reaction | ? | ? | ? |
Codeine | Substance | Deep purplish red [6] | Very dark bluish green [6] | ? | ? |
Creatine | Adulterant | ? | ? | ? | ? |
Diacetylmorphine (Heroin) | Substance | Deep purplish red [6] | Deep bluish green [6] | ? | ? |
Diltiazem | Adulterant | ? | ? | ? | ? |
Dimethoxy-meth | Substance | Moderate olive | Dark brown | ? | ? |
Dimethylterephthalate | Adulterant | ? | ? | ? | ? |
DMT | Substance | ? | ? | ? | ? |
DOM | Substance | ? | ? | ? | ? |
Doxepin | Substance | Blackish red [6] | Very dark red | ? | ? |
Dristan | Substance | Dark grayish red [6] | Light olive brown [6] | ? | ? |
DXM | Substance | Grey with smoke | Yellow | ? | No reaction |
Fentanyl | Substance | ? | ? | ? | ? |
Formaldehyde | Adulterant | ? | ? | ? | ? |
GHB | Substance | ? | ? | ? | ? |
Hydrochlorides | Forms | ? | ? | ? | ? |
Hydroxyzine | Adulterant | ? | ? | ? | ? |
Indoles | Forms | ? | ? | ? | ? |
Isopropylbenzylamine | Adulterant | ? | ? | ? | ? |
Ketamine | Substance | No reaction | No reaction | ? | No reaction |
Levamisole | Adulterant | ? | ? | ? | ? |
Lidocaine | Adulterant | ? | ? | ? | ? |
LSD | Substance | Olive black [6] | Greenish black [6] | ? | ? |
Mace | Substance | Moderate yellow [6] | Dark grayish olive [6] | ? | No reaction |
Mannitol | Adulterant | ? | ? | ? | ? |
MDA | Substance | Dark purple to black [3] [7] | Very dark blue | ? | No reaction |
MDEA | Substance | Dark purple | Dark purple | ? | Blue |
MDMA | Substance | Dark purple to black [3] | Dark purple | ? | Blue |
Mephedrone | Substance | No reaction | No reaction | ? | No reaction |
Mescaline | Substance | Strong orange [9] [6] | Moderate olive [6] | ? | ? |
Methadone | Substance | Light yellowish pink [6] | ? | ? | ? |
Methamphetamine | Substance | Deep reddish orange/Dark reddish brown [6] | No reaction | ? | Blue |
Methaqualone | Substance | No reaction | No reaction | ? | No reaction |
Methoxetamine | Substance | Pink (slow) | Yellow > green > red | ? | Slow pink > red |
Methylone [1] | Substance | Brown | Orange/brown | ? | Blue |
Methylphenidate | Substance | Moderate orange yellow [6] | ? | ? | Pale violet |
Methylsulfonylmethane | Adulterant | ? | ? | ? | ? |
MXE | Substance | ? | ? | ? | ? |
Nutmeg | Adulterant | ? | Brownish Black [6] | ? | ? |
Opiates | Class | ? | White > green > turquoise | ? | ? |
Synthetic opioids (gray death) | Class | ? | ? | ? | ? |
PCP | Substance | ? | ? | ? | ? |
Phenacetin | Adulterant | ? | ? | ? | ? |
Phytocannabinoids | Class | ? | ? | ? | ? |
PMA | Substance | No reaction | No reaction | ? | No reaction |
Primary amines | Forms | ? | ? | ? | ? |
Procaine | Adulterant | ? | ? | ? | ? |
Psilocybin | Substance | ? | ? | ? | ? |
Quinine | Adulterant | ? | ? | ? | ? |
Reducing sugars (sugar) | Adulterant | White > light yellow > black | White > light yellow > black | ? | No reaction |
Secondary amines | Forms | ? | ? | ? | ? |
Sodium bicarbonate | Adulterant | ? | ? | ? | ? |
Strychnine | Adulterant | ? | ? | ? | ? |
Sulfates | Forms | ? | ? | ? | ? |
Synthetic cannabinoids | Class | ? | ? | ? | ? |
THC | Substance | ? | ? | ? | ? |
Tocopheryl acetate | Adulterant | ? | ? | ? | ? |
Tramadol | Substance | ? | ? | ? | ? |
Substance | Type | Reagent test |
---|---|---|
Alcohols | Forms | Lucas test in alcohols is a test to differentiate between primary, secondary, and tertiary alcohols. |
Alkaloids | Forms | Froehde Liebermann Mandelin Marquis Mayer's Mecke Simon's |
Amines, and amino acids | Forms | Folin's |
Barbiturates | Class | Dille–Koppanyi Zwikker |
Benzodiazepines | Class | Zimmermann |
Phytocannabinoids | Class | Duquenois–Levine reagent |
Cocaine | Substance | Scott |
Hydrochlorides | Forms | Silver nitrate |
Indoles | Forms | DMACA reagent Ehrlich |
Primary amines | Forms | Robadope |
Reducing sugars (sugar) | Adulterant | Benedict's Fehling's |
Secondary amines | Forms | Simon's |
Sulfates | Forms | Barium chloride |
Synthetic cannabinoids | Class | Proprietary |
DanceSafe is a Berkeley, California based nonprofit organization founded in 1998 by then 30 year old Emanuel Sferios. They have 17 local chapters in the US and Canada. DanceSafe youth volunteers set up tables at music festivals, raves, and other events to distribute non-biased educational literature focused on harm reduction for safe and responsible drug use, including testing kits so that users may obtain more information about the contents of their pills. They also offer on site peer counseling, health and safety tools and patrols for events that assist in keeping patrons safe.
Marquis reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of formaldehyde and concentrated sulfuric acid, which is dripped onto the substance being tested. The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 5 mL of 40% formaldehyde. Different compounds produce different color reactions. Methanol may be added to slow down the reaction process to allow better observation of the colour change.
A drug test is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers and parole/probation officers screening for drugs prohibited by law and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC. BAC tests are typically administered via a breathalyzer while urinalysis is used for the vast majority of drug testing in sports and the workplace. Numerous other methods with varying degrees of accuracy, sensitivity, and detection periods exist.
4-Fluoroamphetamine, also known as para-fluoroamphetamine (PFA) is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects. As a recreational drug, 4-FA is sometimes sold along with related compounds such as 2-fluoroamphetamine and 4-fluoromethamphetamine.
Nimetazepam is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1964. It possesses powerful hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also a particularly potent anticonvulsant. It is marketed in 5 mg tablets known as Erimin, which is the brand name manufactured and marketed by the large Japanese corporation Sumitomo. Japan is the sole manufacturer of nimetazepam in the world. Outside of Japan, Erimin is available in much of East and Southeast Asia and was widely prescribed for the short-term treatment of severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Sumitomo has ceased manufacturing Erimin since November 2015. It is still available as a generic drug or as Lavol.
Lacing or cutting, in drug culture, refer to the act of using a substance to adulterate substances independent of the reason. The resulting substance is laced or cut.
Reagent testing is one of the processes used to identify substances contained within a pill, usually illicit substances. With the increased prevalence of drugs being available in their pure forms, the terms "drug checking" or "pill testing" may also be used, although these terms usually refer to testing with a wider variety of techniques covered by drug checking.
The Duquenois reagent used in the Rapid Modified Duquenois–Levine test, is an established screening test for the presence of cannabis. The test was initially developed in the 1930s by the French Medical Biochemist, Pierre Duquénois (1904–1986), and was adopted in the 1950s by the United Nations as the preferred test for cannabis, and originally claimed to be specific to cannabis.
Ehrlich's reagent or Ehrlich reagent is a reagent containing p-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen. Several Ehrlich tests use the reagent in a medical test; some are drug tests and others contribute to diagnosis of various diseases or adverse drug reactions. It is named after Nobel Prize winner Paul Ehrlich who used it to distinguish typhoid from simple diarrhoea.
The Liebermann reagent named after Hungarian chemist Leo Liebermann (1852-1926) is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of potassium nitrite and concentrated sulfuric acid. 1 g of potassium nitrite is used for every 10 mL of sulfuric acid. Potassium nitrite may also be substituted by sodium nitrite. It is used to test for cocaine, morphine, PMA and PMMA.
The Mecke reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of selenous acid and concentrated sulfuric acid, which is dripped onto the substance being tested.
The Mandelin reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of ammonium metavanadate and concentrated sulfuric acid. Its primary use is for the detection of ketamine and PMA Unlike the most common reagent test chemicals, it has a deep red colour that changes to yellow if there is no alkaloid, which occurs within about 48 hours of mixing.
Simon's reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It reacts with secondary amines like MDMA and methamphetamine to give a blue solution.
The Froehde reagent is used as a simple spot-test to presumptively identify alkaloids, especially opioids, as well as other compounds. It is composed of a mixture of molybdic acid or a molybdate salt dissolved in hot, concentrated sulfuric acid, which is then dripped onto the substance being tested.
The Dille–Koppanyi reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.1 g of cobalt(II) acetate dihydrate dissolved in 100 ml of methanol mixed with 0.2 ml of glacial acetic acid. Part B made up of is 5% isopropylamine (v/v) in methanol. Two drops of A are dropped onto the substance followed by one drop of B and any change in colour is observed.
The Zwikker reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.5 g of copper (II) sulfate in 100 ml of distilled water. Part B consists of 5% pyridine (v/v) in chloroform. One drop of each is added to the substance to be tested and any change in colour is observed.
The Gallic acid reagent is used as a simple spot-test to presumptively identify drug precursor chemicals. It is composed of a mixture of gallic acid and concentrated sulfuric acid.
The Zimmermann reagent is used as a simple spot-test used in chromatography to presumptively identify alkaloids, especially benzodiazepines, as well as other compounds. It is therefore used in drugs testing.
The Chen-Kao reaction is a chemical method for determining the presence of pseudoephedrine, ephedrine, and similar phenylalkylamines. The reaction is used in spot tests and is also known as Chen-Kao test. The test is often used to distinguish ephedrine, pseudoephedrine, norephedrine, cathinone and methcathinone from amphetamine and methamphetamine, which do not react with Chen’s test reagent.
Drug checking or pill testing is a way to reduce the harm from drug consumption by allowing users to find out the content and purity of substances that they intend to consume. This enables users to make safer choices: to avoid more dangerous substances, to use smaller quantities, and to avoid dangerous combinations.
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