List of polysubstance combinations

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A drug combination chart designed for harm reduction by TripSit Combo 2.png
A drug combination chart designed for harm reduction by TripSit

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.

Contents

Table

To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

Drug 1Drug 2Drug 3Drug 4Polysubstance slang, [2] [3] [4]
or brand name
Intoxication nameComment
Any dissociative Any dissociative Void flipVoid flipping
Any dissociative DMT Dime bar, angel flipDimension flipping, angel flipping
Any depressant Any stimulant Speedball, powerball, over and underPowerballing, speedballing [5]
Any pharmaceutical Any pharmaceutical Polypharmacy Pharming [ citation needed ]Polypharmacy is most commonly defined as the use of five or more medications daily by an individual. [6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications. [6]
Any drug Cannabis Amp joint [7]
Any β-Carboline
containing plant (e.g.
Banisteriopsis caapi
or Peganum harmala )
DMT Ayahuasca, Changa Ayahuasca is drunk. Changa is smoked or vaped.
Any antiretroviral drug Black tar heroin Whoonga, Nyaope [8] Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
Any Benzodiazepine Psilocybin or psilocybin mushrooms Warp TripWarping / Warp TrippingWhen taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by Psilocybin (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state. [9]
Any deliriant or diphen­hydramine MDMA Nightmare flipNightmare flipping
2C-B or the closely related 2C-x LSD or any of the Lysergamides MDMA or any Empathogen-entactogen Ali flip [10] Ali flipping [10] This combination start as a classic Candyflip and end in a Nexus flip.

The LSD [11] is taken first, followed by the MDMA 4 hours later and then 2C-B [11] is taken 2 hours after the MDMA [11] ( so 6 hours after the LSD ).

MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.

This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" [12] with a twist in the end and a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.

2C-B or the closely related 2C-x Mescaline MDMA or any Empathogen-entactogen Selma flip [13] [14] [10] Selma flipping [15] [14] [10] This combination start as a classic Love flip and end in a Nexus flip.

The Mescaline is taken first, followed by the MDMA 4 to 5 hours later and then 2C-B is taken 2 hours after the MDMA .

MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the Mescaline, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.

This combination's goal is to have an experience close to an Ali Flip, [16] but more focused on the empathogenic effects, like the Elias Flip. The idea is to experience an enhanced "Love Flip" with a twist with the 2C-B with a smoother comedown. The whole experience is very long-lasting and can be too intense, as all of these molecules synergize and potentiate each other. Be careful, as some Mescaline cacti may contain MAOIs, which can interact dangerously with serotonergic empathogens.

2C-B MDMA Nexus flip [15] [14] Nexus flipping [15] [14] The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½).

The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.

2C-B DXM Nexuswalk [17] NexuswalkNexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-B LSD There is no official name for this combination, when an empathogen like MDMA is added to this combination it becomes an Ali Flip.
2C-E LSD MDMA Haychmaich flip [5] Haychmaich flipping
2C-P 2C-E Meskini TripMeskini Tripping
2C-E MDMA or any Empathogen-entactogen 2C-B or the closely related 2C-x Elias flip [15] [14] Elias flipping [15] [14] The Elias Flip inspired by the Ali Flip [10] with the use of 2C-E instead of LSD, it can have effects similar to a Selma Flip but with a shorter duration. Be careful with this combination, as 2C-E can have a heavy body load and is different from other 2C-x drugs.
2C-E LSD or closely related Lysergamides MDMA or any Empathogen 2C-B or closely related 2C-x Alias Flip [10] Alias flipping [10] The Alias flip is a very powerful mix between an Elias flip and an Ali flip. [10] The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E.
2C-B-Fly MDMA or any Empathogen-entactogen 2C-B or the closely related 2C-x Ivan flip [15] [14] Ivan flipping [15] [14] The Ivan Flip inspired by the Ali Flip [10] with the use of 2C-B-Fly instead of LSD, it can have effects similar to a Selma Flip as 2C-B-Fly is closely related to Mescaline with a shorter duration. Be careful with this combination, as 2C-B-Fly can have a heavy body load and is different from other 2C-x drugs as it is part of the FLY (psychedelics) family.
Alcohol Caffeine Caffeinated alcoholic drink Irish Coffee
Alcohol Cannabis Tincture of cannabis. Herb and Al. Judgement DayCross fading, twisting, getting twisted [18] Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol Cocaine Snow-coneSnow-coningEthanol is metabolized into cocaethylene [19]
Alcohol MDMA Tipsy flipTipsy flippingIt may be dangerous
Alcohol Nicotine Nicotini A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine Barbiturates Inbetweens [20] Bam
Amphetamine Cannabis LSD Hippie heart attack [ citation needed ]
Amphetamine Cocaine Snow seals
Amphetamine Heroin Bombido [20]
Amphetamine Xanax Orange Dream BlossomCloud RushThe combination is crushed together and insufflated
Belladonna Hashish Alamout black hash [5] Mixed
Caffeine Cannabis Hippie-speedball [21] [22] Hippie-speedballing
Caffeine Diphen­hydramine Sleep walkSleepwalking
Caffeine Meth­amphetamine Ya ba, biker's coffee, kamikaze
Cacao bean Magic mushroom Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD THC Low to moderate doses of CBD might reduce some of the paranoia, anxiety, [23] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose. [24] [25] [26] Low doses of Kanna might also help counteract the anxiety. [27] [28]
Cannabis Cocoa solids Cannabis-infused brownie Cannabis edible
Cannabis Crack cocaine Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola) [29] Cocoa puffs, splitting
Cannabis Crack cocaine Heroin Major Pronin, El Diablo
Cannabis Crack cocaine PCP Jim Jones
Cannabis Damiana Damiana and other herbs can be used as a tobacco alternative for rolling joints. [30]
Cannabis DXM Nicotine Candy blunt
Cannabis Heroin or opium A-bomb, Atom bomb, stuff [5]
Cannabis MDMA Stoner flipStoner flipping
Cannabis Ketamine Stoner Kitty
Cannabis Ketamine Cocaine SimmeredGetting Simmered
Cannabis Nicotine Blunt, joint, spliff, JonkoA rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis Opium Demetra
Cannabis PCP Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom)IllingWet is cannabis dipped in PCP [31]
Cannabis PCP Nicotine Wet blunt, dust blunt, dusted blunt, Kendrick Lamar bluntIlling
Cocaine Heroin Snowball. Other names: Belushi, bombita, murder one, whiz bangSnowballing
Cocaine Heroin LSD Frisco special [5]
Cocaine Heroin Nicotine Flamethrower, primosCigarette laced with cocaine and heroin
Cocaine Ketamine CK1, Calvin Klein, Cable, Party bag, Coquette
Cocaine Ketamine MDMA Ketamollicaine
Cocaine LSD MDMA Candy-flip on a stringCandy-flipping on a stringHigh risk on health
Cocaine MDMA Sugar flipSugar flipping
Cocaine Morphine C & M
Cocaine PCP Space, whack
Cocaine Wine Coca wine Ethanol is metabolized into cocaethylene
Cocaine Quetiapine Q-ball
Codeine Glutethimide Pancakes and syrupsCombination of glutethimide and codeine cough syrup
Codeine Promethazine Lean, purple drank, oil
Crack cocaine Fentanyl Dirty fentanyl, takeover [ citation needed ]
Crack cocaine Heroin Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine LSD Cracid, outerlimits
Crack cocaine Meth­amphetamine Fire, twisters
Crack cocaine Nicotine Coolie, crimmie, woolas
Crack cocaine Nicotine PCP Ozone
Crack cocaine PCP Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magicMissile basing, space basing
Diphen­hydramine DXM OTC flip, counterflippingOTC flipping, robowalking on a string
DMT LSD Cosmo flip, Meadow flipCosmo flipping, meadow flipping
DMT LSD Psilocybin or psilocybin mushroom Super flipSuper flipping
DMT MAOIs Pharmahuasca
DMT Psilocybin or psilocybin mushroom Terence flipTerence flipping
DMT Nitrous oxide Dimension flipDimension flippingNitrous oxide can, allegedly, briefly multiply the effects of psychedelics like DMT or NB-DMT [32]
DMT Alcohol Spyder, Spyder spinSpyder spinning
DXM LSD LSDXM
DXM MDMA Robo flipRobo flipping
DXM Psilocybin or psilocybin mushroom Cherry-bombCherry-bombing
Fentanyl Heroin Birria, chiva loca, Facebook
Fentanyl
(and/or heroin)
Xylazine Tranq, Tranq dope
GHB MDMA Gamma flipGamma flipping
GHB Meth­amphetamine Cherry meth
Hashish Crack cocaine Double zero
Hashish LSD Royal temple ball
Hashish Opium Black hash, black Russian
Heroin Meth­amphetamine Goofball
Heroin Morphine New Jack swing
Heroin PCP Alien sex fiend [5]
Ketamine Amphetamine Fruit of the loom [33]
Ketamine LSD Dolphin flipDolphin flipping
Ketamine MDMA Kitty flip, [34] MK-ultraKitty flipping
Ketamine Psilocybin or Psilocybin mushrooms Funky flip, chonkFunky flipping, chonking
LSD Caffeine Hoffmann FlipHoffmann flipping
LSD Ketamine MDMA Holy Trident, Martin Luther King flip, Galaxy flipHoly Tridenting, Martin Luther King flipping, Galaxy Flipping
LSD MDMA Candy flip [15] [14] Candy flipping [10] [15] [14] Generally, the MDMA is taken approximately 4 hours after the LSD ingestion. A variant of this combination consist on adding 2C-B on top of it before the Candy Flip start coming down and it transforms it into a longer experience known as an Ali Flip. [10]
LSD MDMA Psilocybin or psilocybin mushroom Jedi flip, [34] twilight flipJedi flipping, twilight flipping
LSD MDMA Mushrooms Ketamine Quantum FlipQuantum Flipping
LSD Nitrous oxide GasidNitrous oxide can, allegedly, briefly multiply the effects of psychedelics like LSD. [32]
LSD PCP Black acid
LSD MDMA Ketamine Swalap FlipSwalaped
LSD Psilocybin or psilocybin mushroom God's flesh, Soul Bomb, Alice, [5] Wizard flipWizard flipping
LSD Dissociatives, especially long-lasting ones such as DMXE and/or DCK. MDMA Pixie flipPixie flipping
LSD Dissociatives, especially long-lasting ones such as DMXE and/or DCK. MDMA DMT Behind the curtain, portal flipClimbing behind the curtain, portal flipping
LSD Metocin (4-HO-MET) Neon Bomb, Diamond BombNeon Bombing, Diamond Bombing
MDMA Mescaline or psychoactive cactus Love flip, love tripLove flippingWhen 2C-B is added to this combination it becomes a Selma Flip.
MDMA Methadone Chocolate flipChocolate flipping
MDMA Meth­amphetamine Trailer flipTrailer flipping
MDMA DMT Shaman flip, time flipShaman flipping, time flipping
MDMA Nitrous oxide Nox
MDMA Opiates Poppy flipPoppy flipping
MDMA PCP Domex, elephant flipElephant flipping
MDMA Psilocybin or psilocybin mushroom Hippie flipHippie flipping [35]
MDMA or any Empathogen-entactogen 5-MeO-MiPT 2C-B or the closely related 2C-x Stella Flipping [15] [14] Stella Flip [15] [14]
MDMA Viagra (or other PDE5 inhibitors such as Cialis or Levitra)Sextacy
MDMA Xanax Zen flipZen flipping
MDMA Ketamine Mushrooms Obama FlipObama Flipping
Meth­amphetamine Secobarbital, or other barbituratesPoor man's speedball
Methamphetamine Alpha-PVP Cartel meth
Methaqualone Cannabis White pipe [36] [37] Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India. [37]
Nicotine PCP Chipping, fry cigarette
Pentazocine Tripelannamine T's and blues
Venlafaxine Mirtazepine California rocket fuel

See also

References

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