Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6]
Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
When taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by Psilocybin (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state.[9]
This combination starts as a classic Candyflip and ends in a Nexus flip.
The LSD[11] is taken first, followed by the MDMA 4 hours later and then 2C-B[11] is taken 2 hours after the MDMA[11] ( so 6 hours after the LSD ).
MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.
This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to be able to experience an enhanced "Candyflipping"[12] with a twist in the end and a smoother comedown. The whole experience is long-lasting and can be too intense for some individuals as all of these molecules synergize and potentiate each other.
This combination starts as a classic Love flip and ends in a Nexus flip.
The Mescaline is taken first, followed by the MDMA 4 to 5 hours later and then 2C-B is taken 2 hours after the MDMA.
MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the Mescaline, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.
This combination's goal is to have an experience close to an Ali Flip,[16] but more focused on the empathogenic effects. The idea is to experience an enhanced "Love Flip" with a twist with the 2C-B with a smoother comedown. The whole experience is very long-lasting and can be too intense for some individuals, as all of these molecules synergize and potentiate each other. Be careful, as some Mescaline cacti may contain MAOIs, which can interact dangerously with serotonergic empathogens.
The Elias Flip inspired by the Ali Flip[10] with the use of 2C-E instead of LSD, it can have effects similar to a Selma Flip but with a shorter duration. Be careful with this combination, as 2C-E can have a heavy body load and is different from other 2C-x drugs.
The Alias flip is a very powerful mix between an Elias flip and an Ali flip.[10] The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E.
The Ivan Flip inspired by the Ali Flip[10] with the use of 2C-B-Fly instead of LSD, it can have effects similar to a Selma Flip as 2C-B-Fly is closely related to Mescaline with a shorter duration. Be careful with this combination, as 2C-B-Fly can have a heavy body load and is different from other 2C-x drugs as it is part of the FLY (psychedelics) family.
Low to moderate doses of CBD might reduce some of the paranoia, anxiety,[23] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[24][25][26] Low doses of Kanna might also help counteract the anxiety.[27][28]
A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Generally, the MDMA is taken approximately 4 hours after the LSD ingestion. A variant of this combination consists of adding 2C-B on top of it before the Candy Flip starts coming down and it transforms it into a longer experience known as an Ali Flip.[10]
↑ Grelotti DJ, Closson EF, Smit JA, Mabude Z, Matthews LT, Safren SA, Bangsberg DR, Mimiaga MJ. Whoonga: potential recreational use of HIV antiretroviral medication in South Africa. AIDS Behav. 2014 Mar;18(3):511-8. doi:10.1007/s10461-013-0575-0PMID23955659
↑ Lankenau, Stephen; Clatts, Michael; Welle, Dorinda; Goldsamt, Lloyd; Gwadz, Marya (January 2005). "Street careers: homelessness, drug use, and sex work among young men who have sex with men (YMSM)". International Journal of Drug Policy. 16 (1): 10–18. doi:10.1016/j.drugpo.2004.07.006.
1 2 Keup, Wolfram (June 1971). "The Vocabulary of the Drug User and Alcoholic: A Glossary". The International Journal of the Addictions. 6 (2): 348. doi:10.3109/10826087109057793. PMID4950517.
1 2 McCarthy G, Myers B, Siegfried N (April 2005). "Treatment for methaqualone dependence in adults". The Cochrane Database of Systematic Reviews (2): CD004146. doi:10.1002/14651858.CD004146.pub2. PMID15846700.{{cite journal}}: CS1 maint: article number as page number (link)
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