Tincture of cannabis

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Tincture of cannabis, sometimes known as green dragon, is an alcoholic cannabis concentrate. The solubility of THC in ethanol is greater than 1 g/mL. [1]


According to the European Medicines Agency (EMA) cannabis tinctures (tincturea) are a type of liquid cannabis extract obtained using ethanol, water, glycerol, propylene glycol and fatty oils as extraction solvents, depending on the type of tincture (and also on the solvent used) it can have a specific mass/volume ratio or a specific therapeutic agents content. [2]

Cannabis tinctures are used in the production of specific extracts, like nabiximols.


Cannabis tincture appeared in the United States Pharmacopoeia until 1942 (Australia 1977, UK 1970s). [3] In the 20th century cannabis lost its appeal as a medicinal product, largely due to the development of apparently suitable alternatives, such as the hypodermic needle, water-soluble analgesics and synthetic hypnotics. [4] A major concern of the regulatory authorities at that time was the widespread recreational use of cannabis. [5]

The pharmacological target for cannabis, the endocannabinoid system, has been researched since its discovery in the 1980s.


The tincture is typically made by soaking the dried flowers of the female hemp plant (marijuana) in ethanol. The tetrahydrocannabinol (THC) and other cannabinoids dissolve into the alcohol. Some preparations also extract some of the water-based plant products such as chlorophyll, resulting in a dark green or brown liquid. Baking or drying the cannabis to decarboxylate prior to the alcohol bath increases the amount of THC in the resulting preparation. [6] [ unreliable source? ]

Methods of use

The tincture is ordinarily consumed orally, but may also be applied to the skin.

See also

Related Research Articles

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Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term THC usually refers to the Delta-9-THC isomer with chemical name (−)-trans9-tetrahydrocannabinol. THC is a terpenoid found in cannabis and, like many pharmacologically active phytochemicals, it is assumed to be involved in the plant's evolutionary adaptation against insect predation, ultraviolet light, and environmental stress. THC was first discovered and isolated by Israeli chemist Raphael Mechoulam in Israel in 1964. It was found that, when smoked, THC is absorbed into the bloodstream and travels to the brain, attaching itself to endocannabinoid receptors located in the cerebral cortex, cerebellum, and basal ganglia. These are the parts of the brain responsible for thinking, memory, pleasure, coordination and movement.

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  1. Giuseppe Cannazza; Cinzia Citti; Jenny Wiley; Vidhi Thakkar; Omer S.M. Hasan; Jakob Manthey; Jurgen Rehm; Astrid Otto; Charlotte Probst; Julian Sauer; Jonathon Arnold; Kevin P. Hill; Judith Spahr; Charles V. Pollack; Brock Bakewell (2018). "WHO Expert Committee on Drug – Section 1: Chemistry" (PDF). www.who.int. World Health Organization. Archived from the original (PDF) on November 12, 2020. Retrieved 19 May 2023.
  2. "Compilation of terms and definitions for Cannabis-derived medicinal products" (PDF). European Medicines Agency . 2021-09-22. Archived (PDF) from the original on 2023-06-14. Retrieved 2023-06-15.
  3. David McDonald; Rhonda Moore; Jennifer Norberry; Grant Wardlaw; Nicola Ballenden (1994), "Cannabis in context: history, laws and international treaties", Legislative options for cannabis use in Australia
  4. Affidavit of Dr. Lester Grinspoon, 1997
  5. Roger Pertwee (2006), "Cannabinoid pharmacology: the first 66 years", British Journal of Pharmacology , 147: 163–171, doi:10.1038/sj.bjp.0706406, PMC   1760722 , PMID   16402100
  6. Grotenhermen, Franjo (2001). "FAQ: Why should cannabis products be heated before eating?". cannabis-med.org. Retrieved 16 October 2010.