Drug precursors, also referred to as precursor chemicals or simply precursors , are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances. [1]
International regulators of precursor chemicals consider it necessary to recognise and protect the legal trade of these chemicals, while at the same time preventing their diversion from such trade for use in the illegal manufacture of narcotic drugs and psychoactive substances. For example, phenylacetic acid is used legally in the production of penicillin, flavourings, perfume, and cleaning solutions, but it can also be used in the illegal manufacture of amphetamines and methamphetamine.
The international framework for precursor control is set out under Articles 12 and 13 of the 1988 United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, requiring UN member states to establish and enforce regulatory systems that monitor the trade in their country, as well as movement of precursor chemicals into and out of their country (e.g. transshipment). [2] Monitoring is carried out through measures including the licensing and registration of operators, procedures and requirements governing movement of chemicals, as well as documentation, record keeping and labelling requirements.
The International Narcotics Control Board has also established tools including the Pre-Export Notification Online (PEN-Online) and Precursors Incident Communication (PICS) systems, in addition to annual information reporting through 'Form D' and the International Special Surveillance List (ISSL) for non-controlled and designer chemicals which can be used as precursors themselves for certain illicit drugs or pre-precursors, to support UN Member States in their domestic regulatory efforts and cross-border coordination. There is also harmonised legislation across Europe which puts a control system in place with the aim to achieve a balance between precursor diversion prevention without inhibiting legal trade.
The East Asia and Southeast Asia regions are referred to by many regulatory and law enforcement experts as the largest source for precursor chemicals used for illicit drug production, including by the INCB and UN Office on Drugs and Crime, in-part because a wide variety of chemicals are frequently diverted and trafficked within the region and to other parts of the world including to North America, Central and South America, Oceania (Australia and New Zealand), Europe, and Africa. [3]
Organized crime groups operating in East and Southeast Asia have demonstrated significant sophistication in recent years, as well as their comparative advantage when it comes to sourcing precursors and specialized non-controlled precursor and pre-precursor chemicals for the illicit manufacture of drugs. [4] Aside from regulatory controls that are easily bypassed, Southeast Asia, and in particular the Mekong sub-region, is situated next to two of the world's leading chemical-producing countries, China and India.
However, while the chemical and pharmaceutical industries of China, and to a lesser extent India, are known to be the primary sources of the chemicals used for illicit drug production in Southeast Asia, these industries have also grown rapidly within the region itself in recent years and play an increasingly important role in the illicit drug trade. For example, between 2010 and 2018, outputs of chemicals and their products in Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam, increased in value by nearly 40 per cent from US$132 billion to US$181 billion. [5]
Examples of such precursors and drugs made with them are listed below.
Club drugs, also called rave drugs or party drugs, are a loosely defined category of recreational drugs which are associated with discothèques in the 1970s and nightclubs, dance clubs, electronic dance music (EDM) parties, and raves in the 1980s to today. Unlike many other categories, such as opiates and benzodiazepines, which are established according to pharmaceutical or chemical properties, club drugs are a "category of convenience", in which drugs are included due to the locations they are consumed and/or where the user goes while under the influence of the drugs. Club drugs are generally used by adolescents and young adults.
Methcathinone is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration. It is usually snorted, but can be smoked, injected, or taken orally.
The Misuse of Drugs Act 1971 is an act of the Parliament of the United Kingdom. It represents action in line with treaty commitments under the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
Uncle Fester is the pen name of Steve Preisler, author of such controversial books as Secrets of Methamphetamine Manufacture and Silent Death.
Clandestine chemistry is chemistry carried out in secret, and particularly in illegal drug laboratories. Larger labs are usually run by gangs or organized crime intending to produce for distribution on the black market. Smaller labs can be run by individual chemists working clandestinely in order to synthesize smaller amounts of controlled substances or simply out of a hobbyist interest in chemistry, often because of the difficulty in ascertaining the purity of other, illegally synthesized drugs obtained on the black market. The term clandestine lab is generally used in any situation involving the production of illicit compounds, regardless of whether the facilities being used qualify as a true laboratory.
3,4-Methylenedioxyamphetamine is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug. In its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA). In most countries, the drug is a controlled substance and its possession and sale are illegal.
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids.
The Misuse of Drugs Act 1975 is a New Zealand drug control law that classifies drugs into three classes, or schedules, purportedly based on their projected risk of serious harm. However, in reality, classification of drugs outside of passing laws, where the restriction has no legal power, is performed by the governor-general in conjunction with the Minister of Health, neither of whom is actually bound by law to obey this restriction.
The Misuse of Drugs Act 1973 is a statute of the Parliament of Singapore that enables authorities to prosecute offenders for crimes involving illegal drugs. The law is designed specifically to grant the Government of Singapore, through its agencies such as the Central Narcotics Bureau, enforcement powers to combat offences such as the trafficking, importation or exportation, possession, and consumption of controlled drugs.
Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble in organic solvents. It is a mono-substituted benzene derivative, consisting of an acetone attached to a phenyl group. As such, its systematic IUPAC name is 1-phenyl-2-propanone.
Phenylacetones are a group of organic compounds containing a phenyl moiety and an acetone moiety bonded together, the archetypal example being phenylacetone.
Lacing or cutting, in drug culture, refer to the act of using a substance to adulterate substances independent of the reason. The resulting substance is laced or cut.
The illegal drug trade in China is influenced by factors such as history, location, size, population, and current economic conditions. China has one-sixth of the world's population and a large and expanding economy. China's large land mass, close proximity to the Golden Triangle, Golden Crescent, and numerous coastal cities with large and modern port facilities make it an attractive transit center for drug traffickers. Opium has played an important role in the country's history since before the First and Second Opium Wars in the mid-19th century.
The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971. The Single Convention on Narcotic Drugs of 1961 did not ban the many newly discovered psychotropics, since its scope was limited to drugs with cannabis, coca and opium-like effects.
The Decree-Law 15/93 of January 22 is a Portuguese drug control law implementing the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
MDAI (5,6-methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) in vitro and produces entactogen effects in humans.
3,4-Methylenedioxy-N-ethylamphetamine is an empathogenic psychoactive drug. MDEA is a substituted amphetamine and a substituted methylenedioxyphenethylamine. MDEA acts as a serotonin, norepinephrine, and dopamine releasing agent and reuptake inhibitor.
The Brazilian Controlled Drugs and Substances Act, officially Portaria nº 344/1998, is Brazil's federal drug control statute, issued by the Ministry of Health through its National Health Surveillance Agency (Anvisa). The act also serves as the implementing legislation for the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances in the country.
N-t-BOC-MDMA is a chemical compound which can be both a synthetic precursor to, or a prodrug of the empathogenic drug MDMA. It was first identified in Australia in 2015 as a seizure by customs, and has subsequently been found in China, the Netherlands and other European countries. Originally it was thought to be intended as a non-illegal form of MDMA which could be easily converted into the prohibited final product after importation, however one seizure by police found N-t-BOC-MDMA in the process of being pressed into pills, and experiments with simulated gastric fluid confirmed that it can be broken down to MDMA by human stomach acid. Similar N-protected compounds such as N-t-BOC-methamphetamine, N-p-tosyl-methamphetamine, N-t-BOC-ketamine, N-t-BOC-norketamine, and N-methoxycarbonyl-MDA have also been encountered by law enforcement.