The United States Drug Enforcement Administration (DEA) maintains lists regarding the classification of illicit drugs (see DEA Schedules). It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act [1] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.
Although the list is controlled by the Attorney General, the list is considered a DEA list because the DEA publishes and enforces the list.
Suppliers of these products are subject to regulation and control measures: [2]
Regulation | List I | List II | Tableting and Encapsulating Machines | Special Surveillance List |
---|---|---|---|---|
Know your customer | X | X | X | X |
Annual manufacturing, inventory, and use reports for bulk manufacturers | X | X | X | |
15 day advanced DEA notice required for imports, exports, and transshipments | X | X | ||
15 day advanced DEA notice required for international transactions | X | X | ||
Keep transaction records for at least two years | X | X | ||
Maintain effective security controls | X | X | ||
Required reporting for unusual sales and losses or sales to DEA-identified companies | X | X | ||
Registration required for manufacturing, distribution, import, or export | X | |||
Reports of mail-order sales to non-regulated entities | X |
These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances: [3]
Chemical | Illicit drug |
---|---|
Alpha-phenylacetoacetonitrile and its salts, optical isomers, and salts of optical isomers (APAAN) | phenylacetone, methamphetamine, amphetamine |
Anthranilic acid, its esters, and its salts | methaqualone and analogues |
Benzyl cyanide | phenylacetic acid, phenylacetone, amphetamine |
Ephedrine, its salts, optical isomers, and salts of optical isomers | methamphetamine |
Ergonovine and its salts | lysergic acid diethylamide |
Ergotamine and its salts | lysergic acid diethylamide |
N-Acetylanthranilic acid, its esters, and its salts | methaqualone |
Norpseudoephedrine, its salts, optical isomers, and salts of optical isomers | amphetamine |
Phenylacetic acid, its esters, and its salts | phenylacetone, amphetamine, methamphetamine |
Phenylpropanolamine, its salts, optical isomers, and salts of optical isomers | amphetamine, methamphetamine |
Piperidine and its salts | phencyclidine and analogues |
Pseudoephedrine, its salts, optical isomers, and salts of optical isomers | methamphetamine |
3,4-Methylenedioxyphenyl-2-propanone | MDMA, MDA, MDEA, MDOH |
Methylamine and its salts | methamphetamine |
Ethylamine and its salts | etilamfetamine |
Propionic anhydride | fentanyl |
Isosafrole | MDMA, MDA |
Safrole | MDMA, MDA |
Piperonal | MDMA, MDA |
N-Methylephedrine, its salts, optical isomers, and salts of optical isomers | methamphetamine |
N-Methylpseudoephedrine, its salts, optical isomers, and salts of optical isomers | methamphetamine |
Hydroiodic acid | methamphetamine, amphetamine |
Benzaldehyde | methamphetamine, amphetamine |
Nitroethane | methamphetamine, amphetamine |
Gamma butyrolactone (other names include: GBL; dihydro-2(3H)-furanone; 1,2-butanolide; 1,4-butanolide; 4-hydroxybutanoic acid lactone; gamma-hydroxybutyric acid lactone) | Gamma-Hydroxybutyric acid (GHB) |
Red phosphorus | methamphetamine, amphetamine |
White phosphorus (other names: yellow phosphorus) | methamphetamine, amphetamine |
Hypophosphorous acid and its salts (including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite and sodium hypophosphite) | methamphetamine, amphetamine |
N-Phenethyl-4-piperidone (NPP) | fentanyl |
Iodine | methamphetamine, amphetamine |
Ergocristine and its salts | lysergic acid diethylamide |
N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide (benzylfentanyl) and its salts | fentanyl |
N-phenylpiperidin-4-amine(4-anilinopiperidine; N-phenyl-4-piperidinamine; 4-AP), its amides, its carbamates, and its salts | fentanyl |
3,4-MDP-2-P methyl glycidate (PMK glycidate) and its optical and geometric isomers | MDMA and other "ecstasy"-type substances |
3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) and its salts, optical and geometric isomers, and salts of isomers | MDMA and other "ecstasy"-type substances |
Alpha-phenylacetoacetamide (APAA) and its optical isomers | amphetamine, methamphetamine |
Methyl alpha-phenylacetoacetate (MAPA; methyl 3-oxo-2-phenylbutanoate) and its optical isomers | phenylacetone, methamphetamine, amphetamine |
4-Piperidone | fentanyl |
1-boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) and its salts | fentanyl |
These chemicals are designated as those that are used in the manufacture of controlled substances: [4]
All listed chemicals [5] as specified in 21 CFR 1310.02 (a) or (b). This includes supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls. For each chemical, its illicit manufacturing use is given in parentheses. Some Special Surveillance List chemicals do not have an exclusive manufacturing use for a specific illicit drug but rather have a broad range of uses in both legitimate and illicit manufacturing operations.
Chemical | Illicit drug |
---|---|
Phenyl-2-nitropropene | substituted amphetamines |
1-(4-bromophenyl)propan-1-one | substituted cathinones and substituted amphetamines |
1-(4-chlorophenyl)propan-1-one | substituted cathinones and substituted amphetamines |
1-(4-methylphenyl)propan-1-one | substituted cathinones and substituted amphetamines |
Carbonyldiimidazole | LSD |
1,1-Dichloro-1-fluoroethane | solvent |
N-benzyl-4-piperidone | fentanyl |
chloroephedrine | methamphetamine |
Butyrophenone | substituted cathinones |
Valerophenone | substituted cathinones |
Propiophenone | substituted cathinones |
2C-H | 2C-x and DOx |
2-bromo-1-(4-chlorophenyl)propan-1-one | substituted cathinones and substituted amphetamines |
2-bromo-1-(4-methoxyphenyl)propan-1-one | substituted cathinones and substituted amphetamines |
2-bromo-1-(4-methylphenyl)propan-1-one | substituted cathinones and substituted amphetamines |
2-bromo-1-phenylpentan-1-one | substituted cathinones and substituted amphetamines |
2-bromo-1-phenylpropan-1-one | substituted cathinones and substituted amphetamines |
BMK glycidic acid and esters | methamphetamine |
3-oxo-2-phenylbutanoic acid and its esters | methamphetamine |
3,4-methylenedioxyphenyl-2-nitropropene (MDP2NP) | MDMA |
Ammonia gas | amphetamine, methamphetamine |
Ammonium formate | amphetamine, methamphetamine |
Azobisisobutyronitrile | radical initiator |
Bromobenzene | phencyclidine |
1,4-Butanediol | GHB and Gamma-Butyrolactone |
Cyclohexanone | phencyclidine |
Diethylamine and its salts | lysergic acid diethylamide |
ethyl 3-oxo-4-phenylbutanoate | phenylacetone |
ethyl-3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate (MDP2P ethyl glycidate) | MDMA |
Formamide | amphetamine, methamphetamine |
Formic acid | amphetamine, methamphetamine |
Lithium aluminum hydride | amphetamine, methamphetamine |
Lithium metal | amphetamine, methamphetamine |
Magnesium metal (turnings) | phencyclidine |
Mercuric chloride | amphetamine, methamphetamine |
methyl 2-(1,3-benzodioxol-5-yl)-3-oxobutanoate | MDMA |
N-Methylformamide | amphetamine, methamphetamine |
Organomagnesium halides (Grignard reagents) (e.g. ethylmagnesium bromide and phenylmagnesium bromide) | phencyclidine |
ortho-Toluidine | methaqualone |
2-Phenylethyl bromide | fentanyl |
Phenylethanolamine and its salts | |
Phosphorus pentachloride | lysergic acid diethylamide |
Potassium dichromate | general-purpose oxidizing agent |
Pyridine and its salts | general-purpose solvent |
Sodium borohydride | reducing agent |
Sodium dichromate | general-purpose oxidizing agent |
Sodium metal | phenylacetone |
Sodium triacetoxyborohydride | reducing agent |
para-fluoro-1-boc-4-anilopiperidine | parafluorofentanyl |
Thioglycolic acid | modafinil |
Thionyl chloride | lysergic acid diethylamide |
Trichloromonofluoromethane (aka freon-11, carrene-2) | |
1,1,2-Trichloro-1,2,2-trifluoroethane (aka freon 113) |
The equipment list: [5]
The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 and signed into law by President Richard Nixon. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs.
Butanone, also known as methyl ethyl ketone (MEK) or ethyl methyl ketone, is an organic compound with the formula CH3C(O)CH2CH3. This colorless liquid ketone has a sharp, sweet odor reminiscent of acetone. It is produced industrially on a large scale, but occurs in nature only in trace amounts. It is partially soluble in water, and is commonly used as an industrial solvent. It is an isomer of another solvent, tetrahydrofuran.
Clandestine chemistry is chemistry carried out in secret, and particularly in illegal drug laboratories. Larger labs are usually run by gangs or organized crime intending to produce for distribution on the black market. Smaller labs can be run by individual chemists working clandestinely in order to synthesize smaller amounts of controlled substances or simply out of a hobbyist interest in chemistry, often because of the difficulty in ascertaining the purity of other, illegally synthesized drugs obtained on the black market. The term clandestine lab is generally used in any situation involving the production of illicit compounds, regardless of whether the facilities being used qualify as a true laboratory.
Acetic anhydride, or ethanoic anhydride, is the chemical compound with the formula (CH3CO)2O. Commonly abbreviated Ac2O, it is the simplest isolable anhydride of a carboxylic acid and is widely used as a reagent in organic synthesis. It is a colorless liquid that smells strongly of acetic acid, which is formed by its reaction with moisture in the air.
The United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 is one of three major drug control treaties currently in force. It provides additional legal mechanisms for enforcing the 1961 Single Convention on Narcotic Drugs and the 1971 Convention on Psychotropic Substances. The Convention entered into force on November 11, 1990. As of June 2020, there are 191 Parties to the Convention. These include 186 out of 193 United Nations member states and the Holy See, the European Union, the Cook Islands, Niue, and the State of Palestine.
The Misuse of Drugs Act 1973 is a drug control law in Singapore classifying substances into three categories, Classes A, B, and C. Section 44 provides that "The Minister may, by an order published in the Gazette" add, remove, or transfer drugs among the classes. The statute's penal provisions are severe by most nations' standards, providing for long terms of imprisonment, caning, and capital punishment. The law creates a presumption of trafficking for certain threshold amounts, e.g. 30 grams of cannabis. It also creates a presumption that a person possesses drugs if he possesses the keys to a premises containing the drugs, and that "Any person found in or escaping from any place or premises which is proved or presumed to be used for the purpose of smoking or administering a controlled drug shall, until the contrary is proved, be presumed to have been smoking or administering a controlled drug in that place or premises." Thus, one runs the risk of arrest for drug use by simply being in the company of drug users. The law also allows officers to search premises and individuals, without a search warrant, if he "reasonably suspects that there is to be found a controlled drug or article liable to seizure". Moreover, Section 31 allows officers to demand urinalysis of suspected drug offenders while section 8A prohibits any citizen or permanent resident of Singapore to use any prohibited drug outside of the country, and if found guilty to be punished as if they committed that act within the country.
Cyclohexanone is the organic compound with the formula (CH2)5CO. The molecule consists of six-carbon cyclic molecule with a ketone functional group. This colorless oily liquid has a sweet odor reminiscent of benzaldehyde. Over time, samples of cyclohexanone assume a pale yellow color. Cyclohexanone is slightly soluble in water and miscible with common organic solvents. Billions of kilograms are produced annually, mainly as a precursor to nylon.
3,4-Methylenedioxyphenylpropan-2-one or piperonyl methyl ketone is a chemical compound consisting of a phenylacetone moiety substituted with a methylenedioxy functional group. It is commonly synthesized from either safrole or its isomer isosafrole via oxidation using the Wacker oxidation or peroxyacid oxidation methods. MDP2P is unstable at room temperature and must be kept in the freezer in order to be preserved properly.
The Chemical Diversion and Trafficking Act of 1988 was an amendment to the Controlled Substances Act to regulate precursor chemicals, essential chemicals, tableting machines, and encapsulating machines by imposing record keeping and import/export reporting requirements on transactions involving these materials. Prior to these restrictions being put in place, the U.S. had been the primary source of chemicals used in South American cocaine manufacture. According to the DEA, the Act sharply reduced these precursor exports and cocaine manufacturers responded by purchasing from chemical suppliers outside the U.S. The U.S. in turn successfully lobbied for inclusion of chemical controls in the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, which included two Tables of controlled precursors.
Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble in organic solvents. It is a mono-substituted benzene derivative, consisting of an acetone attached to a phenyl group. As such, its systematic IUPAC name is 1-phenyl-2-propanone.
Phenylacetic acid, also known by various synonyms, is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a strong honey-like odor. Endogenously, it is a catabolite of phenylalanine. As a commercial chemical, because it can be used in the illicit production of phenylacetone, it is subject to controls in countries including the United States and China.
Benzyl chloride, or α-chlorotoluene, is an organic compound with the formula C6H5CH2Cl. This colorless liquid is a reactive organochlorine compound that is a widely used chemical building block.
The Étard reaction is a chemical reaction that involves the direct oxidation of an aromatic or heterocyclic bound methyl group to an aldehyde using chromyl chloride. For example, toluene can be oxidized to benzaldehyde.
N-Phenethyl-4-piperidinone (NPP) is a derivative of 4-piperidinone with the molecular formula C13H17NO. It is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl.
Ergocristine is an ergopeptine and one of the ergot alkaloids. As of February 24, 2010 ergocristine has been federally regulated. Because of the existing Controlled Substance Act regulatory controls on the LSD precursors lysergic acid, lysergic acid amide, ergotamine, and ergonovine, clandestine laboratory operators have sought uncontrolled sources of precursor material for the production of LSD. This has led to the illicit utilization of the precursor chemical ergocristine as a direct substitute for ergotamine and ergonovine for the illicit production of LSD. In fact, the largest clandestine LSD laboratory ever, William Leonard Pickard and Clyde Apperson, that was seized by the Drug Enforcement Administration (DEA) utilized ergocristine as the LSD precursor according to court documents.
The Decree-Law 15/93 of January 22 is a Portuguese drug control law implementing the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
The Comprehensive Methamphetamine Control Act of 1996 is a bill enacted into law by the 104th Congress of the United States. It mandated registration of persons trading in list I chemicals from the DEA list of chemicals. A fee for such registration was initially $595 but later reduced to $116. It is regarded as one of the major drug laws in the United States.
European law on illicit drug precursors:
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.