Mamushi

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Mamushi
Mamushi togurosugata.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Chordata
Class: Reptilia
Order: Squamata
Suborder: Serpentes
Family: Viperidae
Genus: Gloydius
Species:
G. blomhoffii
Binomial name
Gloydius blomhoffii
(H. Boie, 1826)
Synonyms
  • Trigonocephalus Blomhoffii
    H. Boie, 1826
  • Trigonocephalus [(Halys)] affinis
    Gray, 1849
  • Trigonocephalus [(Halys)] Blomhoffii
    — Gray, 1849
  • T[rigonocephalus]. Blomhoffii var. megaspilus
    Cope, 1860
  • Halys blomhoffii
    W. Peters, 1862
  • T[rigonocephalus]. blomhoffii
    Jan, 1963
  • Ancistrodon blomhoffii
    Boulenger, 1896
  • Agkistrodon blomhoffii ? affinis
    Stejneger, 1907
  • Ancistrodon halys blomhoffii
    — Ross Smith, 2019
  • Agkistrodon blomhoffii blomhoffii
    Sternfeld, 1916
  • A[ncistrodon]. blomhoffii blomhoffii
    F. Werner, 1922
  • Agkistrodon blomhoffii affinis
    — F. Werner, 1922
  • Ankistrodon halys blomhoffii
    — Pavloff, 1926
  • Agkistrodon halys blomhoffii
    — Mell, 1929
  • Agkistrodon halys affinis
    — Mell, 1929
  • Gloydius blomhoffii blomhoffii
    Hoge & Romano-Hoge, 1981
  • Agkistrodon affinis
    Gloyd & Conant, 1990 [2]

Gloydius blomhoffii, commonly known as the mamushi, [3] Japanese moccasin, Japanese pit viper, Qichun snake, Salmusa or Japanese mamushi, [4] is a venomous pit viper species found in Japan. It was once considered to have 4 subspecies, but it is now considered monotypic. [5]

Contents

This species, along with the yamakagashi ( Rhabdophis tigrinus ) and the Okinawan habu ( Protobothrops flavoviridis ), are the most venomous snakes in Japan. [6] Every year, 2000–3000 people in Japan are bitten by a mamushi. Bitten victims typically require one week of treatment in a hospital. Severe bites require intensive care, and approximately 10 victims die annually. [7] [8]

Etymology

The specific name, blomhoffii, is in honor of Jan Cock Blomhoff, who was director of the Dutch trading colony in Nagasaki, Japan from 1817 to 1824. [9]

Description

The average length of mature individuals is 45–81 cm (17+34-31+78 inches); the longest specimen ever recorded had a length of 91 cm (36 in). [3]

The body pattern consists of a pale gray, reddish-brown, or yellow-brown background, overlaid with a series of irregularly-shaped lateral blotches. These blotches are bordered with black and often have lighter centers. The head is dark brown or black, with beige or pale-gray sides. [3]

Sign warning for mamushi in Kyoto, Japan Mamushi chui.jpg
Sign warning for mamushi in Kyoto, Japan

Common names

The common name in English is mamushi, [3] or Japanese mamushi. [4] The common name in Japanese is mamushi (). In Korea, it is known as Korean : 살무사; RR : salmusa or Korean : 살모사; RR : salmosa. In China, it is known as the Qichun snake (七寸子) or soil snake/viper (土巴蛇、土蝮蛇、土夫蛇、土公蛇).

Geographic range

It is found in Japan. According to Gloyd and Conant, there is no evidence to support claims that this species occurs in the Ryukyu Islands. [10] The type locality given is "Japan". [2]

Habitat

It occurs in a range of habitats, including swamps, marshes, meadows, open woodland, rocky hillsides, and montane rock outcroppings. [3]

Diet

A mamushi lurking in a bush a little above ground-level, waiting to ambush passing prey Gloydius blomhoffii.jpg
A mamushi lurking in a bush a little above ground-level, waiting to ambush passing prey

It is typically an ambush predator that uses its excellent camouflage to hide itself in vegetation or leaf litter. It hunts and eats mainly rodents, but also small birds, lizards, and insects. It is often found in and around farmland due to the associated rodent populations. [3]

Venom

Characteristics

The venom of this species varies very little in Japan in terms of both its potency and its effects. [11] According to Yoshimitsu (2005), this species and the Okinawan habu (Protobothrops flavoviridis), another pit viper, are the most venomous snakes in Japan. [6] The venom's lethality as measured by LD50 in mice following intraperitoneal injection is in the range 0.3 mg/kg [12] to 1.22 mg/kg. [13] The venom mostly contains haemolytic toxins, but it also has two neurotoxins—an alpha-toxin that is a post-synaptic inhibitor and a beta-toxin that is a pre-synaptic inhibitor. [13] Because the beta-toxin acts pre-synaptically, its effects cannot be blocked or treated by anticholinesterases. [13] The venom contains an anticoagulant, mamushi L-amino-acid oxidase (M-LAO). [14] It also contains the peptide ablomin which is highly similar in amino acid sequence to that of the venom, helothermine, of the Mexican beaded lizard (Heloderma horridum). [15]

Treatments for envenomations

There is an effective antivenom manufactured in both Japan and China. [11] Its effectiveness is increased when co-administered with a serine protease inhibitor such as FOY (see, e.g. Camostat). [16] In common with many other venomous snakes, the mamushi is highly resistant to its own venom because of various neutralising factors present in its sera including phospholipase A2 (PLA2) inhibitors; these and other inhibitors are the target of antivenom development. [17]

Every year, 2000-3000 people in Japan are bitten by mamushi, severe bites require intensive care, and approximately 10 victims die. [7] There have been case reports of kidney failure, [18] visual disturbances, [19] palsy, and miscarriage in pregnant women. [20]

In one study in Japan, mamushi bite victims required a median duration of 7 days of hospital treatment followed by a median of 31 days of out-patient treatment; the time to achieve a full recovery was even longer, taking up to several months. [8] The treatment protocol involved incision of the wound for exclusion of the venom, and injection of mamushi antivenom. [8]

Taxonomy

This species is similar to the cottonmouths and copperheads ( Agkistrodon sp.) of the Americas, and it was long considered part of the same group (see synonymy). [2]

Related Research Articles

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<span class="mw-page-title-main">Eastern copperhead</span> Species of reptile

The eastern copperhead, also known simply as the copperhead, is a species of venomous snake, a pit viper, endemic to eastern North America; it is a member of the subfamily Crotalinae in the family Viperidae.

<span class="mw-page-title-main">Mamba</span> Genus of venomous snakes

Mambas are fast-moving, highly venomous snakes of the genus Dendroaspis in the family Elapidae. Four extant species are recognised currently; three of those four species are essentially arboreal and green in colour, whereas the black mamba, Dendroaspis polylepis, is largely terrestrial and generally brown or grey in colour. All are native to various regions in sub-Saharan Africa and all are feared throughout their ranges, especially the black mamba. In Africa there are many legends and stories about mambas.

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<span class="mw-page-title-main">Snakebite</span> Injury caused by bite from snakes

A snakebite is an injury caused by the bite of a snake, especially a venomous snake. A common sign of a bite from a venomous snake is the presence of two puncture wounds from the animal's fangs. Sometimes venom injection from the bite may occur. This may result in redness, swelling, and severe pain at the area, which may take up to an hour to appear. Vomiting, blurred vision, tingling of the limbs, and sweating may result. Most bites are on the hands, arms, or legs. Fear following a bite is common with symptoms of a racing heart and feeling faint. The venom may cause bleeding, kidney failure, a severe allergic reaction, tissue death around the bite, or breathing problems. Bites may result in the loss of a limb or other chronic problems or even death.

<i>Gloydius</i> Genus of snakes

Gloydius is a genus of venomous pitvipers endemic to Asia, also known as Asian moccasins or Asian ground pit vipers. Named after American herpetologist Howard K. Gloyd, this genus is very similar to the North American genus Agkistrodon. 24 species are currently recognized.

<span class="mw-page-title-main">Snake venom</span> Highly modified saliva containing zootoxins

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<i>Gloydius himalayanus</i> Species of snake

Gloydius himalayanus also known as the Himalayan pit viper or the Himalayan viper is a venomous pitviper species found along the southern slopes of the Himalayas in Pakistan, India and Nepal. No subspecies are currently recognized. Himalayan pit vipers have been found up to 4900m above sea level, which makes it the highest living snake ever found.

<i>Deinagkistrodon</i> Genus of snakes

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<i>Protobothrops</i> Genus of snakes

Protobothrops is a genus of venomous pit vipers found in Asia.

<i>Daboia palaestinae</i> Species of snake

Daboia palaestinae, also known as the Palestine viper, is a viper species endemic to the Levant. Like all vipers, it is venomous. It is considered a leading cause of snakebite within its range. No subspecies are currently recognized.

<i>Gloydius saxatilis</i> Species of snake

Gloydius saxatilis is a venomous pitviper species endemic to Russia, China and the Korean Peninsula. No subspecies are currently recognized.

<i>Ovophis okinavensis</i> Species of snake

Ovophis okinavensis, commonly known as the hime habu (ヒメハブ), Ryukyu Island pit viper, and the Okinawan pitviper, is a venomous pitviper species found in the Ryukyu Islands of Japan. No subspecies are currently recognized.

<i>Gloydius brevicauda</i> Species of snake

Gloydius brevicauda is a venomous pitviper species endemic to China and the Korean Peninsula.

<i>Gloydius tsushimaensis</i> Species of snake

Gloydius tsushimaensis, or the Tsushima Island pitviper, is a species of venomous snake in the family Viperidae. The species is endemic to Tsushima Island in Japan.

Ablomin is a toxin present in the venom of the Japanese Mamushi snake, which blocks L-type voltage-gated calcium channels.

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<span class="mw-page-title-main">Cysteine-rich secretory protein</span>

Cysteine-rich secretory proteins, often abbreviated as CRISPs, are a group of glycoproteins. They are a subgroup of the CRISP, antigen 5 and Pr-1 (CAP) protein superfamily and also contain a domain related to the ShK toxins. They are substantially implicated in the functioning of the mammalian reproductive system. CRISPs are also found in a variety of snake venoms where they inhibit both smooth muscle contraction and cyclic nucleotide-gated ion channels.

References

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  9. Beolens, Bo; Watkins, Michael; Grayson M (2011). The Eponym Dictionary of Reptiles. Baltimore: Johns Hopkins University Press. xiii + 296 pp. ISBN   978-1-4214-0135-5. (Gloydius blomhoffi, p. 28).
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  11. 1 2 Fukuda, Tadashi; Iwaki, Masaaki; Hong, Seung Hwa; Oh, Ho Jung; Wei, Zhu; Morokuma, Kazunori; Ohkuma, Kunio; Dianliang, Lei; Arakawa, Yoshichika; Takahashi, Motohide (2006). "Standardization of Regional Reference for Mamushi (Gloydius blomhoffii ) Antivenom in Japan, Korea, and China". Japanese Journal of Infectious Diseases. 59 (1): 20–4. PMID   16495629.
  12. Hung, Yao-Ching; Sava, Vasyl; Hong, Meng-Yen; Huang, G. Steven (2004). "Inhibitory effects on phospholipase A2 and antivenin activity of melanin extracted from Thea sinensis Linn". Life Sciences. 74 (16): 2037–47. doi:10.1016/j.lfs.2003.09.048. PMID   14967198.
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  14. Sakurai, Yoshihiko; Shima, Midori; Matsumoto, Tomoko; Takatsuka, Hideo; Nishiya, Katsumi; Kasuda, Shogo; Fujimura, Yoshihiro; Yoshioka, Akira (2003). "Anticoagulant activity of M-LAO, l-amino acid oxidase purified from Agkistrodon halys blomhoffii, through selective inhibition of factor IX". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1649 (1): 51–57. doi:10.1016/S1570-9639(03)00157-2. PMID   12818190.
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  19. Takeshita, T; Yamada, K; Hanada, M; Oda-Ueda, N (2003). "Case report: Extraocular muscle paresis caused by snakebite". Kobe Journal of Medical Sciences. 49 (1–2): 11–5. PMID   12698017.
  20. Nasu, Kaei; Ueda, Tami; Miyakawa, Isao (2004). "Intrauterine Fetal Death Caused by Pit Viper Venom Poisoning in Early Pregnancy". Gynecologic and Obstetric Investigation. 57 (2): 114–6. doi:10.1159/000075676. PMID   14691344. S2CID   39491397.

Further reading