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Cerebral amyloid angiopathy (CAA) is a form of angiopathy in which amyloid beta peptide deposits in the walls of small to medium blood vessels of the central nervous system and meninges. The term congophilic is sometimes used because the presence of the abnormal aggregations of amyloid can be demonstrated by microscopic examination of brain tissue after staining with Congo red. The amyloid material is only found in the brain and as such the disease is not related to other forms of amyloidosis.
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Familial amyloid polyneuropathy, also called transthyretin-related hereditary amyloidosis, transthyretin amyloidosis abbreviated also as ATTR, or Corino de Andrade's disease, is an autosomal dominant neurodegenerative disease. It is a form of amyloidosis, and was first identified and described by Portuguese neurologist Mário Corino da Costa Andrade, in 1952. FAP is distinct from senile systemic amyloidosis (SSA), which is not inherited, and which was determined to be the primary cause of death for 70% of supercentenarians who have been autopsied. FAP can be ameliorated by liver transplantation.
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References
- ↑ "Pepys, Prof. Mark Brian". Who's Who. doi:10.1093/ww/9780199540884.013.U30545. ISBN 978-0-19-954088-4 . Retrieved 28 April 2019.
- 1 2 3 "EC/1998/26: Pepys, Mark Brian". London: The Royal Society. Archived from the original on 13 July 2015.
- ↑ "Iris View Profile". iris.ucl.ac.uk. Retrieved 13 December 2017.
- ↑ Booth, D. R.; Sunde, M; Bellotti, V; Robinson, C. V.; Hutchinson, W. L.; Fraser, P. E.; Hawkins, P. N.; Dobson, C. M.; Radford, S. E.; Blake, C. C.; Pepys, M. B. (1997). "Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis". Nature. 385 (6619): 787–93. Bibcode:1997Natur.385..787B. doi:10.1038/385787a0. PMID 9039909. S2CID 4347837.
- ↑ "Prof Sir Mark Pepys". Institutional Research Information Service. Retrieved 28 April 2019.
- ↑ "The Royal Society GlaxoSmithKline Prize and Lecture (1976) (2002)". royalsociety.org. Archived from the original on 9 June 2008. Retrieved 3 April 2009.
- ↑ "Mark Pepys". royalsociety.org. Retrieved 13 December 2017.
- ↑ "No. 60009". The London Gazette (Supplement). 31 December 2011. p. 1.
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