Sheena Radford | |
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Born | Sheena Elizabeth Radford |
Alma mater | |
Spouse | Alan Berry [1] |
Scientific career | |
Fields | |
Institutions | |
Thesis | Domains and conformational flexibility in the catalytic mechanism of the 2-oxo acid dehydrogenase complexes (1987) |
Website | https://biologicalsciences.leeds.ac.uk/biological-sciences/staff/127/professor-sheena-radford https://astbury.leeds.ac.uk/people/professor-sheena-radford/ |
Sheena Elizabeth Radford is a British biophysicist, and Astbury Professor of Biophysics and a Royal Society Research Professor in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. [1] [2] [3] [4] Radford is the Associate Editor of the Journal of Molecular Biology. [5]
Radford received her BSc in Biochemistry at the University of Birmingham [5] in 1984, [6] and her PhD in Biochemistry at the University of Cambridge in 1987. [1] [7] [8] Radford completed a post-doctoral fellowship at the University of Oxford. [6]
Radford was a postdoc and Royal Society University Research Fellow at the University of Oxford, then worked as a Lecturer in Biochemistry and Molecular Biology at the University of Leeds in 1995, progressing to Reader in 1998 and Professor in 2000. She became the deputy director of the Astbury Centre for Structural Molecular Biology in 2009 then Director in 2012 - 2021. [5] Radford's research [9] investigates protein folding, protein aggregation and amyloid disease. Her multi-disciplinary research focuses include such disciplines as biochemistry, chemistry and medicine.
One major research focus is the role of protein misfolding in the onset of amyloidogenic diseases, including dialysis-related amyloidosis, Alzheimer's, Parkinson's and Type II diabetes. This has been done with the use of native mass spectrometry, NMR and single molecule methods to characterize intermediates of protein folding and in amyloid formation. [5] A second research focus is on the folding of outer membrane proteins of Gram-negative organisms. Understanding the mechanics of how these proteins fold will help derive new antibiotics. A third arm looks at how the shelf life of pharmaceutical drugs could be extended.
Radford was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2010 [10] and a Fellow of the Royal Society (FRS) in 2014. [11]
Radford is a member of Faculty of 1000. [12]
Radford was appointed Officer of the Order of the British Empire (OBE) in the 2020 Birthday Honours for services to molecular biology research. [13]
Sir Alan Roy Fersht is a British chemist at the MRC Laboratory of Molecular Biology, Cambridge, and an Emeritus Professor in the Department of Chemistry at the University of Cambridge. He was Master of Gonville and Caius College, Cambridge from 2012 to 2018. He works on protein folding, and is sometimes described as a founder of protein engineering.
Sir John Ernest Walker is a British chemist who won the Nobel Prize in Chemistry in 1997. As of 2015 Walker is Emeritus Director and Professor at the MRC Mitochondrial Biology Unit in Cambridge, and a Fellow of Sidney Sussex College, Cambridge.
Richard Henderson is a British molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank. "Thanks to his work, we can look at individual atoms of living nature, thanks to cryo-electron microscopes we can see details without destroying samples, and for this he won the Nobel Prize in Chemistry."
Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.
Dame Jean Olwen Thomas, is a Welsh biochemist, former Master of St Catharine's College, Cambridge, and Chancellor of Swansea University.
Dame Janet Maureen Thornton, is a senior scientist and director emeritus at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL). She is one of the world's leading researchers in structural bioinformatics, using computational methods to understand protein structure and function. She served as director of the EBI from October 2001 to June 2015, and played a key role in ELIXIR.
Dame Carol Vivien Robinson is a British chemist and former president of the Royal Society of Chemistry (2018–2020). She was a Royal Society Research Professor and is the Dr Lee's Professor of Physical and Theoretical Chemistry, and a professorial fellow at Exeter College, University of Oxford. She is the founding director of the Kavli Institute for Nanoscience Discovery, University of Oxford, and she was previously professor of mass spectrometry at the chemistry department of the University of Cambridge.
Sir Christopher Martin Dobson was a British chemist, who was the John Humphrey Plummer Professor of Chemical and Structural Biology in the Department of Chemistry at the University of Cambridge, and Master of St John's College, Cambridge.
Roger Sidney Goody is an English chemist who served as director at the Max Planck Institute for Molecular Physiology in Dortmund from 1993 until 2013. Since 2013 he is Emeritus Director of the institute.
Richard Nelson Perham, FRS, FMedSci, FRSA, was Professor of biochemistry at the University of Cambridge, and Master of St John's College, Cambridge 2004–07. He was also editor-in-chief of FEBS Journal from 1998 to 2013.
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David Ron FRS is a British biochemist.
Gideon John Davies is a professor of chemistry in the Structural Biology Laboratory (YSBL) at the University of York, UK. Davies is best known for his ground-breaking studies into carbohydrate-active enzymes, notably analysing the conformational and mechanistic basis for catalysis and applying this for societal benefit. In 2016 Davies was appointed the Royal Society Ken Murray Research Professor at the University of York. Gideon Davies has recently been elected to the Council of the Royal Society.
G. Marius Clore MAE, FRSC, FMedSci, FRS is a British-born, Anglo-American molecular biophysicist and structural biologist. He was born in London, U.K. and is a dual U.S./U.K. Citizen. He is a Member of the National Academy of Sciences, a Fellow of the Royal Society, a Fellow of the Academy of Medical Sciences, a Fellow of the American Academy of Arts and Sciences, a NIH Distinguished Investigator, and the Chief of the Molecular and Structural Biophysics Section in the Laboratory of Chemical Physics of the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. National Institutes of Health. He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. Clore's discovery of previously undetectable, functionally significant, rare transient states of macromolecules has yielded fundamental new insights into the mechanisms of important biological processes, and in particular the significance of weak interactions and the mechanisms whereby the opposing constraints of speed and specificity are optimized. Further, Clore's work opens up a new era of pharmacology and drug design as it is now possible to target structures and conformations that have been heretofore unseen.
Jane Clarke is a British biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge. In 2023, she was elected to the National Academy of Sciences.
Iain William Mattaj FRS FRSE is a British scientist and Honorary Professor at Heidelberg University in Germany. From 2005 to 2018 he was Director General of the European Molecular Biology Laboratory (EMBL). He stepped down from the position at the end of 2018 following his appointment to Human Technopole. In January 2019 he took office as the first Director of Human Technopole, the new Italian institute for life sciences in Milan, Italy.
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Sir David Ian Stuart is a Medical Research Council Professor of Structural Biology at the Wellcome Trust Centre for Human Genetics at the University of Oxford where he is also a Fellow of Hertford College, Oxford. He is best known for his contributions to the X-ray crystallography of viruses, in particular for determining the structures of foot-and-mouth disease virus, bluetongue virus and the membrane-containing phages PRD1 and PM2. He is also director of Instruct and Life Sciences Director at Diamond Light Source.
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