A micelle or micella is an aggregate of surfactant amphipathic lipid molecules dispersed in a liquid, forming a colloidal suspension. A typical micelle in water forms an aggregate with the hydrophilic "head" regions in contact with surrounding solvent, sequestering the hydrophobic single-tail regions in the micelle centre.
In polymer chemistry, a copolymer is a polymer derived from more than one species of monomer. The polymerization of monomers into copolymers is called copolymerization. Copolymers obtained from the copolymerization of two monomer species are sometimes called bipolymers. Those obtained from three and four monomers are called terpolymers and quaterpolymers, respectively. Copolymers can be characterized by a variety of techniques such as NMR spectroscopy and size-exclusion chromatography to determine the molecular size, weight, properties, and composition of the material.
A drug carrier or drug vehicle is a substrate used in the process of drug delivery which serves to improve the selectivity, effectiveness, and/or safety of drug administration. Drug carriers are primarily used to control the release of drugs into systemic circulation. This can be accomplished either by slow release of a particular drug over a long period of time or by triggered release at the drug's target by some stimulus, such as changes in pH, application of heat, and activation by light. Drug carriers are also used to improve the pharmacokinetic properties, specifically the bioavailability, of many drugs with poor water solubility and/or membrane permeability.
Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by the trade names Pluronic, Kolliphor, and Synperonic.
Small-angle X-ray scattering (SAXS) is a small-angle scattering technique by which nanoscale density differences in a sample can be quantified. This means that it can determine nanoparticle size distributions, resolve the size and shape of (monodisperse) macromolecules, determine pore sizes, characteristic distances of partially ordered materials, and much more. This is achieved by analyzing the elastic scattering behaviour of X-rays when travelling through the material, recording their scattering at small angles. It belongs to the family of small-angle scattering (SAS) techniques along with small-angle neutron scattering, and is typically done using hard X-rays with a wavelength of 0.07 – 0.2 nm. Depending on the angular range in which a clear scattering signal can be recorded, SAXS is capable of delivering structural information of dimensions between 1 and 100 nm, and of repeat distances in partially ordered systems of up to 150 nm. USAXS can resolve even larger dimensions, as the smaller the recorded angle, the larger the object dimensions that are probed.
Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAM, PNIPAAm, NIPA, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s. It can be synthesized from N-isopropylacrylamide which is commercially available. It is synthesized via free-radical polymerization and is readily functionalized making it useful in a variety of applications.
Temperature-responsive polymers or thermoresponsive polymers are polymers that exhibit drastic and discontinuous changes in their physical properties with temperature. The term is commonly used when the property concerned is solubility in a given solvent, but it may also be used when other properties are affected. Thermoresponsive polymers belong to the class of stimuli-responsive materials, in contrast to temperature-sensitive materials, which change their properties continuously with environmental conditions. In a stricter sense, thermoresponsive polymers display a miscibility gap in their temperature-composition diagram. Depending on whether the miscibility gap is found at high or low temperatures, either an upper critical solution temperature (UCST) or a lower critical solution temperature (LCST) exists.
Richard John Puddephatt, was born 1943 in Aylesbury, England. He is a distinguished university professor in the department of chemistry at the University of Western Ontario, in London, Ontario, Canada. Richard is a former holder of a Canada research chair in material synthesis. He has been studying the fundamental chemistry of gold and other precious metals in the development of new materials for potential applications in health care and electronics. Puddephatt's research interests involve organometallic chemistry related to catalysis and materials science, and he is considered a world expert on platinum and gold chemistry. He has authored two books: The Chemistry of Gold and The Periodic Table of Elements.
John Texter is an American engineer, chemist, and educator. He is professor emeritus of polymer and coating technology at Eastern Michigan University (EMU) in Ypsilanti, Michigan, and managing consultant of Strider Research Corporation (SRC). He is best known for his work in applied dispersion technology, small particle science, and stimuli-responsive polymers based on ionic liquids, for his international conference organization activities, including Particles 2001, Particles 2002, etc., and the Gordon Research Conferences, Chemistry at Interfaces and Chemistry of Supramolecules and Assemblies, and for his editing of the Primers page for nanoparticles.org.
Nanoparticles are classified as having at least one of its dimensions in the range of 1-100 nanometers (nm). The small size of nanoparticles allows them to have unique characteristics which may not be possible on the macro-scale. Self-assembly is the spontaneous organization of smaller subunits to form larger, well-organized patterns. For nanoparticles, this spontaneous assembly is a consequence of interactions between the particles aimed at achieving a thermodynamic equilibrium and reducing the system’s free energy. The thermodynamics definition of self-assembly was introduced by Professor Nicholas A. Kotov. He describes self-assembly as a process where components of the system acquire non-random spatial distribution with respect to each other and the boundaries of the system. This definition allows one to account for mass and energy fluxes taking place in the self-assembly processes.
Andrew Ian Cooper is a British chemist who is a professor of chemistry in the Department of Chemistry at the University of Liverpool.
Eugenia Eduardovna Kumacheva is a University Professor and Distinguished Professor of Chemistry at the University of Toronto. Her research interests span across the fields of fundamental and applied polymers science, nanotechnology, microfluidics, and interface chemistry. She was awarded the L'Oréal-UNESCO Awards for Women in Science in 2008 "for the design and development of new materials with many applications including targeted drug delivery for cancer treatments and materials for high density optical data storage". In 2011, she published a book on the Microfluidic Reactors for Polymer Particles co-authored with Piotr Garstecki. She is Canadian Research Chair in Advanced Polymer Materials. She is Fellow of the Royal Society (FRS) and a Fellow of the Royal Society of Canada (FRSC).
Rachel O'Reilly is a British chemist and Professor at the University of Birmingham. She works at the interface of biology and materials, creating polymers that can mimic natural nanomaterials such as viruses and cells. She is a Fellow of the Royal Society of Chemistry and of the Royal Society.
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential application for effective drug delivery.
Fiona C. Meldrum is a British scientist who is a Professor of Inorganic Chemistry at the University of Leeds where she works on bio-inspired materials and crystallisation processes. She won the 2017 Royal Society of Chemistry Interdisciplinary Prize.
So-Jung Park 박소정(朴昭靜) is a professor of chemistry at Ewha Womans University, Republic of Korea. Her research considers the self-assembly of nanoparticles and functional molecules for biomedical and optoelectronic devices. She serves as Associate Editor of ACS Applied Materials & Interfaces and Nanoscale.
Katharina Landfester is a German chemist who is a professor at the Max Planck Institute for Polymer Research. Her research considers the physical properties of droplets, polymerisation in emulsion and the synthesis of nanoparticles.
Vitaliy Khutoryanskiy FRSC FAPS is a British and Kazakhstani scientist, a Professor of Formulation Science and a Royal Society Industry Fellow at the University of Reading. His research focuses on polymers, biomaterials, nanomaterials, drug delivery, and pharmaceutical sciences. Khutoryanskiy has published over 200 original research articles, book chapters, and reviews. His publications have attracted > 12000 citations and his current h-index is 54. He received several prestigious awards in recognition for his research in polymers, colloids and drug delivery as well as for contributions to research peer-review and mentoring of early career researchers. He holds several honorary professorship titles from different universities.
Jimmy W. Mays is an American polymer scientist, academic, and author. He is a Professor Emeritus at the University of Tennessee.
Yves Gnanou is a French chemist, academic and author. He is the Ibn Alhaytham Distinguished Professor of Chemistry at King Abdullah University of Science and Technology.
