Martek Biosciences Corporation

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Martek Biosciences Corporation was a pharmaceutical company based in Columbia, Maryland. [1] It was acquired by Royal DSM NV in 2011, [2] and produces nutritional ingredients for the food, beverage, dietary supplement and early life nutrition industries. By 2004, the company had a 70% market share in the United States for baby formula supplements, and about 30% globally. [3]

Martek Biosciences Corporation
FormerlyAlgatex
Nasdaq:  MATK [3]
IndustryPharmaceutical R&D
FoundedMay 1985
FounderDavid Kyle, Richard Radmer and Paul Behrens [4]
FateAcquired by DSM [5]
HeadquartersColumbia, Maryland [3]
ProductsDHA and ARA, extracted from fungus [3]
BrandsFormulaid
Revenue$185 million [3]  (2004)
$47 million [3]  (2004)
Number of employees
600 (2005) [3]

The history of this company begins in outer space. In the early-1980s, Martin Marietta began investigating the potential benefits that algae might bring to long-term space flight, having been contracted by NASA under the Closed Environment Life Support System (CELSS) program. The scientists involved realized the broader potential for algae in human health, and when Martin Marietta ended their involvement with the CELSS program in 1985 (they left bioscience research altogether), they left the company and formed Algatex in May 1985, which they renamed to Martek by September of the same year. "Martek" was in fact the name of the Martin Marietta division they had been affiliated with originally. [4] Martek research identified the microalgae Crypthecodinium cohnii , which produces high levels of DHA, and the soil fungus Mortierella alpina that yields ARA, both being important human nutrients. The company's first licensing agreement came in 1992 for commercialized versions of these nutrients, marketed as life'sDHA and life'sARA. Martek subsequently went public in 1994. [1] [6] This same year, the first commercial products supplemented with Formulaid were sold in Europe. [4]

Martek was one of the thousands of company's who have received assistance from the Small Business Administration. In fact, it received around 40 SBIR grants in its early years, constituting the firm's primary source of funds for Research & Development. The company made its first revenue seventeen years after its formation. [1]

As of 1996, the company's leading product was Formulaid, a dietary supplement containing DHA and ARA, "an algae-based, vegetable-like oil". The company was granted a U.S. patent for Formulaid formulation in 1994. [6] [note 1] By 2005, production of the supplement was done in the United States at plants in Kingstree, South Carolina and Winchester, Kentucky. [3] [note 2] In 2004, more than 50% of the company's revenue came from sales to Mead Johnson, maker of Enfamil Lipil. [3] By 2006, Martek had contracted with Mead Johnson to be its exclusive supplier of DHA and ARA supplements for infant formula products. [7]

With respect to business model, the infant formula market has been "relatively stable", allowing for firm prediction of revenue and production needs; however, stepping into the general food market (e.g. breakfast cereal additives) would lead to a substantial increase in uncertainty from a financial and supply point of view. [3] Addition of Martek's supplement to baby formula can result in a 10% to 20% price increase over the base product. [note 2] Martek's heavy revenue reliance on Mead Johnson had, in the mid-2000s, led to some investor concerns. [7] As of 2007 and 2009, supplements for infant formula accounted for 91% of the company's sales, [8] [5] bringing one commentator to note the firm was a "pure play" investment target. [9] In February 2010, Martek acquired Amerifit, a dietary supplement company, in a bid to expand beyond supplements for baby food. [5]

In 2011, Martek was acquired by DSM for $1.1 billion as part of their expansion out of bulk chemical manufacture and sales. [5] [10]

As of 2005, the company typically marked its own DHA, but contracted out for the manufacture of ARA, which requires supplemental fermentation of the source fungus. [note 2] ARA is a commonly made supplement across many manufacturers. DHA, on the other hand, has its main competition in fish oil supplements, where DHA has the advantage of being tasteless and odorless compared to fish oil. [note 2]

Related Research Articles

Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond, three atoms away from the terminal methyl group in their chemical structure. They are widely distributed in nature, being important constituents of animal lipid metabolism, and they play an important role in the human diet and in human physiology. The three types of omega−3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA can be found in plants, while DHA and EPA are found in algae and fish. Marine algae and phytoplankton are primary sources of omega−3 fatty acids. DHA and EPA accumulate in fish that eat these algae. Common sources of plant oils containing ALA include walnuts, edible seeds, and flaxseeds as well as hempseed oil, while sources of EPA and DHA include fish and fish oils, and algae oil.

<span class="mw-page-title-main">Infant formula</span> Manufactured food designed for feeding infants

Infant formula, baby formula, or simply formula ; or baby milk or infant milk, is a manufactured food designed and marketed for feeding to babies and infants under 12 months of age, usually prepared for bottle-feeding or cup-feeding from powder or liquid. The U.S. Federal Food, Drug, and Cosmetic Act (FFDCA) defines infant formula as "a food which purports to be or is represented for special dietary use solely as a food for infants by reason of its simulation of human milk or its suitability as a complete or partial substitute for human milk".

<span class="mw-page-title-main">Dietary supplement</span> Product that provides additional source of nutrients

A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order to increase the quantity of their consumption. The class of nutrient compounds includes vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential to life, but are marketed as having a beneficial biological effect, such as plant pigments or polyphenols. Animals can also be a source of supplement ingredients, such as collagen from chickens or fish for example. These are also sold individually and in combination, and may be combined with nutrient ingredients. The European Commission has also established harmonized rules to help insure that food supplements are safe and appropriately labeled.

Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them.

<i>Chlorella</i> Genus of green algae

Chlorella is a genus of about thirteen species of single-celled green algae of the division Chlorophyta. The cells are spherical in shape, about 2 to 10 μm in diameter, and are without flagella. Their chloroplasts contain the green photosynthetic pigments chlorophyll-a and -b. In ideal conditions cells of Chlorella multiply rapidly, requiring only carbon dioxide, water, sunlight, and a small amount of minerals to reproduce.

A boycott was launched in the United States on July 4, 1977, against the Swiss-based multinational food and drink processing corporation Nestlé. The boycott expanded into Europe in the early 1980s and was prompted by concerns about Nestlé's "aggressive marketing" of infant formulas, particularly in underdeveloped countries. The boycott has been cancelled and renewed because of the business practices of Nestlé and other substitute manufacturers monitored by the International Baby Food Action Network (IBFAN). Organizers of the boycott as well as public health researchers and experts consider breast milk to be the best nutrition source for infants. The World Health Organization (WHO) recommends infants to be exclusively breastfed for the first six months of their lives, nevertheless, sometimes nutritional gaps need to be filled if breastfeeding is unsuitable, not possible, or inadequate.

<span class="mw-page-title-main">Fish oil</span> Oil derived from the tissues of oily fish

Fish oil is oil derived from the tissues of oily fish. Fish oils contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), precursors of certain eicosanoids that are known to reduce inflammation in the body and improve hypertriglyceridemia. There has been a great deal of controversy in recent years about the role of fish oil in cardiovascular disease, with recent meta-analyses reaching different conclusions about its potential impact. The most promising evidence supports supplementation for prevention of cardiac death.

<span class="mw-page-title-main">Vegetarian nutrition</span> Nutritional and human health aspects of vegetarian diets

Vegetarian nutrition is the set of health-related challenges and advantages of vegetarian diets.

<span class="mw-page-title-main">DSM (company)</span> Dutch multinational corporation

Koninklijke DSM N.V., is a Dutch multinational corporation active in the fields of health, nutrition and materials. Headquartered in Heerlen, at the end of 2017 DSM employed 21,054 people in approximately 50 countries and posted net sales of €8.632 billion in 2018 and €9.204 billion in 2021.

<span class="mw-page-title-main">Eicosapentaenoic acid</span> Chemical compound

Eicosapentaenoic acid is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). It also has the trivial name timnodonic acid. In chemical structure, EPA is a carboxylic acid with a 20-carbon chain and five cis double bonds; the first double bond is located at the third carbon from the omega end.

<span class="mw-page-title-main">Docosahexaenoic acid</span> Chemical compound

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. In physiological literature, it is given the name 22:6(n-3). It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk, fatty fish, fish oil, or algae oil.

<span class="mw-page-title-main">Milk substitute</span> Alternative substance that resembles milk

A milk substitute is any substance that resembles milk and can be used in the same ways as milk. Such substances may be variously known as non-dairy beverage, nut milk, grain milk, legume milk, mock milk and alternative milk.

<span class="mw-page-title-main">Nutrition and pregnancy</span> Nutrient intake and dietary planning undertaken before, during and after pregnancy

Nutrition and pregnancy refers to the nutrient intake, and dietary planning that is undertaken before, during and after pregnancy. Nutrition of the fetus begins at conception. For this reason, the nutrition of the mother is important from before conception as well as throughout pregnancy and breast feeding. An ever-increasing number of studies have shown that the nutrition of the mother will have an effect on the child, up to and including the risk for cancer, cardiovascular disease, hypertension and diabetes throughout life.

<span class="mw-page-title-main">Similac</span>

Similac is a brand of infant formula that was developed by Alfred Bosworth of Tufts University and marketed by Abbott Laboratories. It was first released in the late 1920s, and then reformulated and concentrated in 1951. Today, Similac is sold in 96 countries worldwide.

Gripe water is a non-prescription product sold in many countries around the world to relieve colic and other gastrointestinal ailments and discomforts of infants. No evidence supports the efficacy of gripe water and one limited study in India questions whether the consumption of gripe water is related to vomiting in babies that already showed signs of colic. The original formula contained alcohol and sugar in addition to sodium bicarbonate and dill oil. Present-day products do not contain alcohol, and may contain fennel, ginger, chamomile or lemon balm in addition to or replacement for dill oil. Some gripe water products still contain sugar, while others may contain charcoal. Amounts given are one to several teaspoons per day.

Enfamil is an American brand of infant formula that is made by Mead Johnson, a subsidiary of Reckitt. From 1989 through 2011, Mead Johnson used Beatrix Potter's Peter Rabbit on its U.S. packaging. However, in 2012, the company transitioned to its signature duck across it U.S. Enfamil product line. Enfamil is a product name associated with formulas for babies.

TerraVia Holdings, Inc. was a publicly held biotechnology company in the United States. TerraVia used proprietary technology to transform a range of low-cost plant-based sugars into high-value oils and whole algae ingredients. TerraVia supplied a variety of sustainable algae-based food ingredients to a number of brands, which included Hormel Food Corporation, Utz Quality Foods Inc., and Enjoy Life Foods. TerraVia also sold its own culinary algae oil under the Thrive Algae Oil brand.

<span class="mw-page-title-main">Vegan nutrition</span> Nutritional and human health aspects of vegan diets

Vegan nutrition refers to the nutritional and human health aspects of vegan diets. A well-planned, balanced vegan diet is suitable to meet all recommendations for nutrients in every stage of human life. Vegan diets tend to be higher in dietary fiber, magnesium, folic acid, vitamin C, vitamin E, iron, and phytochemicals; and lower in calories, saturated fat, cholesterol, long-chain omega-3 fatty acids, vitamin D, calcium, zinc, and vitamin B12.

<span class="mw-page-title-main">Vegetarian and vegan dog diet</span> Adequate meat-free or animal-free nutrition

As in the human practice of veganism, vegan dog foods are those formulated with the exclusion of ingredients that contain or were processed with any part of an animal, or any animal byproduct. Vegan dog food may incorporate the use of fruits, vegetables, cereals, legumes including soya, nuts, vegetable oils, as well as any other non-animal based foods.

Seaweed oil, also called algae oil, is used for making food, with the purified product almost colorless and odorless.

References

  1. 1 2 3 "Martek Biosciences Corporation". SBA 100. Retrieved 2022-04-10.
  2. ↑ Matthews, Sheenagh DSM Says ‘No Pause’ in Acquisitions as Profit Tops Estimates Bloomberg, Apr 27, 2011.(subscription required)
  3. 1 2 3 4 5 6 7 8 9 10 DuPlessis, Jim (6 March 2005). "How algae grow baby brains, S.C. economy". Sunday Business. The State . pp. F1, F3. Retrieved 2022-04-15– via Newspapers.com.
  4. 1 2 3 Shaw, Donna (19 February 1997). "Algae a lucrative source of nutrient supplements". Post-Crescent . Knight-Ridder. pp. A8. Retrieved 2022-04-15.
  5. 1 2 3 4 Gray-Block, Aaron (21 December 2010). "DSM hits M&A road with $1.1 billion Martek buy". Reuters. Retrieved 2022-04-15.
  6. 1 2 "Nutritional Products from Space Research". NASA Spinoff (NASA Technology Transfer Program). 1996. Retrieved 2022-04-10.
  7. 1 2 "Martek Biosciences". Business (The Motley Fool). The Republic (Columbus, Indiana). 25 June 2006. pp. B2. Retrieved 2022-04-15– via Newspapers.com.
  8. ↑ "Marek Biosciences profit rises 89%". Business (Earnings). The Baltimore Sun . 5 June 2008. pp. 2D. Retrieved 2022-04-15.
  9. ↑ "Baby steps to big gains". Business Outlook (Markets). Albuquerque Journal . 7 August 2008. p. 13. Retrieved 2022-04-15– via Newspapers.com.
  10. ↑ Will Yakowicz. "With A $120 Million War Chest, Brightseed Is Unlocking The Fat-Fighting Power Of Hemp". Forbes.

Notes

  1. ↑ US 5374657 "Microbial oil mixtures and uses thereof ."
  2. 1 2 3 4 Second page of "How algae grow baby brains..."
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