| Methionine-S-oxide reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.8.4.5 | ||||||||
| CAS no. | 70248-65-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Methionine-S-oxide reductase (EC 1.8.4.5, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase) is an enzyme with systematic name L-methionine:thioredoxin-disulfide S-oxidoreductase. [1] [2] [3] This enzyme catalyses the following chemical reaction
- L-methionine + thioredoxin disulfide + H2O L-methionine S-oxide + thioredoxin
In the reverse reaction, dithiothreitol can replace reduced thioredoxin.
S-Methionine-S-oxide and R-Methionine-S-oxide require different Methionine-S-oxide reductases, named Methionine-S-oxide reductase A and Methionine-S-oxide reductase B respectively. [4] A Methionine-S-oxide reductase B named AtMSRB plays a large role in salt tolerance in Arabidopsis Thaliana. [5]
