Methyl halide transferase

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Methyl halide transferase
Identifiers
EC no. 2.1.1.165
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Methyl halide transferase (EC 2.1.1.165, MCT, methyl chloride transferase, S-adenosyl-L-methionine:halide/bisulfide methyltransferase, AtHOL1, AtHOL2, AtHOL3, HMT, S-adenosyl-L-methionine: halide ion methyltransferase, SAM:halide ion methyltransferase) is an enzyme with systematic name S-adenosylmethionine:iodide methyltransferase. [1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

Contents

S-adenosyl-L-methionine + iodide S-adenosyl-L-homocysteine + methyl iodide

This enzyme contributes to the methyl halide emissions from Arabidopsis thaliana .

Chloride transfer

The salt marsh plant Batis maritima contains the enzyme methyl chloride transferase that catalyzes the synthesis of chloromethane (CH3Cl) from S-adenosine-L-methionine and chloride. [7] This protein has been purified and expressed in E. coli , and seems to be present in other organisms such as white rot fungi ( Phellinus pomaceus ), [2] red algae ( Endocladia muricata ), and the ice plant ( Mesembryanthemum crystallinum ), each of which is a known CH3Cl producer. [7] [8]

Related Research Articles

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References

  1. ↑ Ni, X.; Hager, L.P. (1999). "Expression of Batis maritima methyl chloride transferase in Escherichia coli". Proc. Natl. Acad. Sci. USA. 96 (7): 3611–3615. Bibcode:1999PNAS...96.3611N. doi: 10.1073/pnas.96.7.3611 . PMC   22342 . PMID   10097085.
  2. 1 2 Saxena, D.; Aouad, S.; Attieh, J.; Saini, H.S. (1998). "Biochemical characterization of chloromethane emission from the wood-rotting fungus Phellinus pomaceus". Appl. Environ. Microbiol. 64 (8): 2831–2835. Bibcode:1998ApEnM..64.2831S. doi:10.1128/AEM.64.8.2831-2835.1998. PMC   106779 . PMID   9687437.
  3. ↑ Attieh, J.M.; Hanson, A.D.; Saini, H.S. (1995). "Purification and characterization of a novel methyltransferase responsible for biosynthesis of halomethanes and methanethiol in Brassica oleracea". J. Biol. Chem. 270 (16): 9250–9257. doi: 10.1074/jbc.270.16.9250 . PMID   7721844.
  4. ↑ Itoh, N.; Toda, H.; Matsuda, M.; Negishi, T.; Taniguchi, T.; Ohsawa, N. (2009). "Involvement of S-adenosylmethionine-dependent halide/thiol methyltransferase (HTMT) in methyl halide emissions from agricultural plants: isolation and characterization of an HTMT-coding gene from Raphanus sativus (daikon radish)". BMC Plant Biol. 9: 116. doi: 10.1186/1471-2229-9-116 . PMC   2752461 . PMID   19723322.
  5. ↑ Ohsawa, N.; Tsujita, M.; Morikawa, S.; Itoh, N. (2001). "Purification and characterization of a monohalomethane-producing enzyme S-adenosyl-L-methionine: halide ion methyltransferase from a marine microalga, Pavlova pinguis". Biosci. Biotechnol. Biochem. 65 (11): 2397–2404. doi: 10.1271/bbb.65.2397 . PMID   11791711.
  6. ↑ Nagatoshi, Y.; Nakamura, T. (2007). "Characterization of three halide methyltransferases in Arabidopsis thaliana". Plant Biotechnol. 24 (5): 503–506. doi: 10.5511/plantbiotechnology.24.503 .
  7. 1 2 Ni X, Hager LP; Purification of the Enzyme (1998). "cDNA Cloning of Batis maritima Methyl Chloride Transferase". Proc Natl Acad Sci USA. 95 (22): 12866–71. doi: 10.1073/pnas.95.22.12866 . PMC   23635 . PMID   9789006.
  8. ↑ Ni X, Hager LP (1999). "Expression of Batis maritima Methyl Chloride Transferase in Escherichia coli". Proc Natl Acad Sci USA. 96 (7): 3611–5. Bibcode:1999PNAS...96.3611N. doi: 10.1073/pnas.96.7.3611 . PMC   22342 . PMID   10097085.
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