U.S. Route 77 is a major north–south United States Numbered Highway which extends for 1,305 miles (2,100 km) in the central United States. As of 2005, Its southern terminus is in Brownsville, Texas, at Veteran's International Bridge on the Mexican border, where it connects with both Mexican Federal Highway 101 and Mexican Federal Highway 180, and the highway's northern terminus is in Sioux City, Iowa, at an interchange with Interstate 29 (I-29), less than 1⁄2 mile (800 m) north of the Nebraska state line.
U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.
U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route.
U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four other north–south routes are longer: US 1, US 41, US 59, and US 87, while US 83 follows a straighter north-south path than all of these. Nearly half of its mileage is in the state of Texas. The highway's northern terminus is north of Westhope, North Dakota, at the Canadian border, where it continues as Manitoba Highway 83 (PTH 83). The southern terminus is at the Veterans International Bridge in Brownsville, Texas. Together, US 83 and PTH 83 form a continuously numbered north-south highway with a combined distance of 3,450 kilometres (2,140 mi).
U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate 90. Its southern terminus is in Refugio, Texas, at the southern intersection of U.S. Highway 77 and Alternate US 77.
Nebraska Highway 50 (N-50) is a north–south highway in the state of Nebraska. The southern terminus is at the Nebraska-Kansas border near Du Bois. The northern terminus is in the Millard neighborhood of Omaha at an intersection with U.S. Highway 275 (US 275) and N-92. It is a two lane highway except for the section from Springfield north to the southern edge of the Millard neighborhood in Omaha, which is a divided highway.
Nebraska Highway 5 (N-5) is a 11.04-mile (17.77 km) state highway in Thayer County, Nebraska, United States, that connects U.S. Route 136 (US 136), just north of Deshler, with Nebraska Highway 4 (N-4), between Davenport and Carleton. N-5 is entirely a two-lane road that runs through rural agricultural area and is part of three National Historic Trails: the Oregon National Historic Trail, the California National Historic Trail, and the Pony Express National Historic Trail.
Nebraska Highway 8 (N-8) is a highway in southern and southeastern Nebraska. Its western terminus is at Nebraska Highway 14 in Superior and its eastern terminus is at U.S. Highway 73 (US 73) in Falls City. It runs through the southern tier of counties in Nebraska and is always within 10 miles (16 km) of the Kansas border.
Nebraska Highway 11 (N-11) is a state highway in central and northern Nebraska, United States. Its southern terminus is at Interstate 80 (I-80) south of Wood River. Its northern terminus is at the South Dakota border north of Butte. The highway goes through the eastern portion of the Sand Hills.
Nebraska Highway 12 is a highway in northern and northeastern Nebraska. It has a western terminus at U.S. Highway 83 in Valentine and an eastern terminus at U.S. Highway 20 west of Jackson. The highway largely lies within 10 miles (16 km) of the South Dakota border its entire length. The highway has been designated the Outlaw Trail Scenic Byway.
Nebraska Highway 99 is a highway in southeastern Nebraska. It has a southern terminus at the Kansas border south of Burchard and just north of Summerfield, Kansas. Its northern terminus is north of Burchard at an intersection with Nebraska Highway 4. It lies entirely in Pawnee County. It is a part of a three-state "Highway 99" which includes K-99 in Kansas and Oklahoma State Highway 99.
Nebraska Highway 14 (N-14) is a highway in the U.S. state of Nebraska. It has a southern terminus at the Kansas border, where it continues south as K-14, southwest of Superior and a northern terminus east of Niobrara at the South Dakota border.
Nebraska Highway 25 is a highway in southwestern Nebraska. It runs for 87 miles (140 km). Its southern terminus is at the Kansas border south of Trenton. Its northern terminus is at U.S. Highway 30 in Sutherland.
Nebraska Highway 27 is a highway in Nebraska. It is divided into three segments. The southernmost segment begins at the Kansas border and goes north to Haigler. The middle segment begins at Interstate 80 near Chappell and goes north to Oshkosh. The northernmost segment begins at Ellsworth and goes north to the South Dakota border.
Nebraska Highway 61 (N-61) is a 234.82-mile (377.91 km) state highway in western Nebraska, United States. The southern terminus of N-61 is at the Kansas border south of Benkelman, where the highway continues south as K-161. The northern terminus is at the South Dakota border north of Merriman, where the highway continues north as South Dakota Highway 73.
Nebraska Highway 87 is a highway in northwestern Nebraska. It has a southern terminus at Nebraska Highway 2 in Alliance. Its northern terminus is at the South Dakota border where it continues in northward as South Dakota Highway 407.
Nebraska Highway 121 is a highway in northeastern Nebraska. It is a discontinuous highway with three segments:
Nebraska Highway 71 is a highway in western Nebraska. Its southern terminus is at the Colorado border south of Kimball, as a continuation of Colorado State Highway 71. Its northern terminus is at the South Dakota border northwest of Crawford, where it continues as South Dakota Highway 71.
K-19 is a 33.915-mile-long (54.581 km) state highway in the U.S. state of Kansas. From U.S. Route 50 (US-50) to K-19 Spur it is signed as north–south and from K-19 Spur to US-281 it is signed as east–west. K-19's southern terminus is at US-50 in Belpre, and the eastern terminus is at US-281 east of Seward.
Wyoming Highway 92 (WYO 92) is a 16.47-mile-long (26.51 km) Wyoming state highway in the eastern Goshen County that travels from Torrington to the Nebraska state line. It is part of a continuous 886-mile (1,426 km) four-state "Highway 92" which begins in Wyoming, goes through Nebraska and Iowa, and ends in La Moille, Illinois.
K-15 south of Fairbury 
SD 19 northeast of Maskell 
