Nucleoporin 205

NUP205
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	5IJN, 5IJO
Identifiers
Aliases	NUP205 , C7orf14, NPHS13, nucleoporin 205kDa, nucleoporin 205
External IDs	OMIM: 614352 MGI: 2141625 HomoloGene: 45971 GeneCards: NUP205
Gene location (Human)
Chr.	Chromosome 7 (human)
End	135,648,757 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	35,224,531 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; anterior pituitary; ; skin of abdomen; ; left uterine tube; ; tibial nerve; ; right uterine tube; ; cerebellar hemisphere; ; minor salivary gland; ; spleen;
	Top expressed in
	spermatocyte; ; hand; ; primitive streak; ; spermatid; ; seminiferous tubule; ; maxillary prominence; ; abdominal wall; ; hair follicle; ; endocardial cushion; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of nuclear pore ; protein binding ;
Cellular component	nuclear membrane ; nuclear envelope ; membrane ; nuclear periphery ; nuclear pore inner ring ; nuclear pore ; nucleus ; host cell ;
Biological process	mRNA transport ; nuclear pore complex assembly ; viral transcription ; protein sumoylation ; mitotic nuclear membrane disassembly ; nucleocytoplasmic transport ; regulation of cellular response to heat ; protein transport ; viral process ; intracellular transport of virus ; tRNA export from nucleus ; mRNA export from nucleus ; regulation of gene silencing by miRNA ; regulation of glycolytic process ; transport ; nuclear pore organization ;
	Sources:Amigo / QuickGO
Orthologs
	23165
	70699
	ENSG00000155561
	ENSMUSG00000038759
	Q92621
	n/a
	NM_015135 ; NM_001329434
	NM_027513
	NP_001316363 ; NP_055950
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.^[5]^[6]^[7]

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.^[5] It has also been recently shown that Nup205 is required for proper viral gene expression.^[8]

Related Research Articles

Nuclear pore glycoprotein-210 (gp210) is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane. and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore. A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.

Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene.

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.

Nucleoporin GLE1 is a protein that in humans is encoded by the GLE1 gene on chromosome 9.

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.

Nucleoporin 37 (Nup37) is a protein that in humans is encoded by the NUP37 gene.

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.

Gene gating is a phenomenon by which transcriptionally active genes are brought next to nuclear pore complexes (NPCs) so that nascent transcripts can quickly form mature mRNA associated with export factors. Gene gating was first hypothesised by Günter Blobel in 1985. It has been shown to occur in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster as well as mammalian model systems.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155561 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038759 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: NUP205 nucleoporin 205kDa".
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
↑ Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664 . PMID 9348540.
↑ Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG (Nov 2014). "Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression". J Virol. 88 (22): 13249–59. doi:10.1128/JVI.00933-14. PMC 4249058 . PMID 25210169.

Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243 . PMID 15703211.
Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664 . PMID 9348540.
Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S (2002). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–8. doi: 10.1074/jbc.M207439200 . PMID 12228227.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Hase ME, Cordes VC (2003). "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex". Mol. Biol. Cell. 14 (5): 1923–40. doi:10.1091/mbc.E02-09-0620. hdl:11858/00-001M-0000-0028-3D33-F. PMC 165087 . PMID 12802065.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422 . PMID 19615732.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155561 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038759 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: NUP205 nucleoporin 205kDa".

[pmid9039502-6] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.

[pmid9348540-7] Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664 . PMID 9348540.

[8] Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG (Nov 2014). "Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression". J Virol. 88 (22): 13249–59. doi:10.1128/JVI.00933-14. PMC 4249058 . PMID 25210169.

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v t e Autoantigens
Dehydrogenase	Branched-chain alpha-keto acid dehydrogenase complex Oxoglutarate dehydrogenase Pyruvate dehydrogenase
Transglutaminase	Epidermal transglutaminase Tissue transglutaminase
Nucleoporins	NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP210 NUP205 NUP214
Other	Acetylcholine receptor Actin Apolipoprotein H Cardiolipin Centromere Filaggrin (Citrullinate) Gangliosides Sp100 nuclear antigen Thrombin Topoisomerase

Nucleoporin 205

Contents

Function

Related Research Articles

References

Further reading