Phenylpyruvate tautomerase

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phenylpyruvate tautomerase
Identifiers
EC no. 5.3.2.1
CAS no. 9023-54-5
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In enzymology, phenylpyruvate tautomerase or Macrophage migration inhibitory factor (EC 5.3.2.1) is an enzyme that catalyzes the chemical reaction

keto-phenylpyruvate enol-phenylpyruvate

Phenylpyruvate tautomerase has also been found to exhibit the same keto-enol tautomerism for 4-Hydroxyphenylpyruvic acid, which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring. [1]

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.

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References

  1. Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Björk P, Jacobsson L, Rorsman H (1997). "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase". FEBS Lett. 417 (1): 85–8. Bibcode:1997FEBSL.417...85R. doi:10.1016/s0014-5793(97)01261-1. PMID   9395080. S2CID   27800700.