Phenylpyruvate tautomerase

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phenylpyruvate tautomerase
Identifiers
EC no. 5.3.2.1
CAS no. 9023-54-5
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In enzymology, phenylpyruvate tautomerase or Macrophage migration inhibitory factor (EC 5.3.2.1) is an enzyme that catalyzes the chemical reaction

keto-phenylpyruvate enol-phenylpyruvate

Phenylpyruvate tautomerase has also been found to exhibit the same keto-enol tautomerism for 4-Hydroxyphenylpyruvic acid, which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring. [1]

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.

Related Research Articles

<span class="mw-page-title-main">Enoyl CoA isomerase</span> Type of enzyme

Enoyl-CoA-(∆) isomerase (EC 5.3.3.8, also known as dodecenoyl-CoA- isomerase, 3,2-trans-enoyl-CoA isomerase, ∆3 ,∆2 -enoyl-CoA isomerase, or acetylene-allene isomerase, is an enzyme that catalyzes the conversion of cis- or trans-double bonds of coenzyme A bound fatty acids at gamma-carbon to trans double bonds at beta-carbon as below:

<span class="mw-page-title-main">Macrophage migration inhibitory factor</span> Protein-coding gene in the species Homo sapiens

Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. MIF is an important regulator of innate immunity. The MIF protein superfamily also includes a second member with functionally related properties, the D-dopachrome tautomerase (D-DT). CD74 is a surface receptor for MIF.

<span class="mw-page-title-main">3-methyl-2-oxobutanoate dehydrogenase</span> Class of enzymes

In enzymology, a 3-methyl-2-oxobutanoate dehydrogenase (EC 1.2.4.4) is an enzyme that catalyzes the chemical reaction

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dTDP-4-dehydrorhamnose 3,5-epimerase Enzyme

In enzymology, a dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, a L-dopachrome isomerase is an enzyme that catalyzes the chemical reaction

In enzymology, an oxaloacetate tautomerase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-glucuronate 4-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Leukotriene-A4 hydrolase</span>

Leukotriene-A4 hydrolase is an enzyme that catalyzes the reaction which converts Leukotriene A4 to Leukotriene B4. It is a bifunctional zinc enzyme with different amino acids attached to it to aid in the catalysis of the reaction. It also acts as an aminopeptidase. Leukotriene-A4 hydrolase is a cytosolic protein and is found in almost all mammalian cells, tissues and organelles that have been examined.

<span class="mw-page-title-main">2-Dehydro-3-deoxy-phosphogluconate aldolase</span> Class of enzymes

The enzyme 2-dehydro-3-deoxy-phosphogluconate aldolase, commonly known as KDPG aldolase, catalyzes the chemical reaction

The enzyme D-dopachrome decarboxylase (EC 4.1.1.84) catalyzes the chemical reaction

<span class="mw-page-title-main">Prephenate dehydratase</span>

The enzyme prephenate dehydratase (EC 4.2.1.51) catalyzes the chemical reaction

In enzymology, a beta-galactoside alpha-2,6-sialyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Polynucleotide adenylyltransferase</span> Class of enzymes

In enzymology, a polynucleotide adenylyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Megakaryocyte-associated tyrosine kinase</span> Protein-coding gene in the species Homo sapiens

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

<span class="mw-page-title-main">MST1</span> Protein-coding gene in the species Homo sapiens

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

<span class="mw-page-title-main">DDT (gene)</span> Protein-coding gene in the species Homo sapiens

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.

<span class="mw-page-title-main">Phenylpyruvic acid</span> Chemical compound

Phenylpyruvic acid is the organic compound with the formula C6H5CH2C(O)CO2H. It is a keto acid.

<span class="mw-page-title-main">3-Maleylpyruvic acid</span> Chemical compound

3-Maleylpyruvic acid, or 3-maleylpyruvate, is a dicarboxylic acid formed by the oxidative ring opening of gentisic acid by gentisate 1,2-dioxygenase during the metabolism of tyrosine. It is converted into 3-fumarylpyruvate by maleylpyruvate isomerase.

References

  1. Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Björk P, Jacobsson L, Rorsman H (1997). "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase". FEBS Lett. 417 (1): 85–8. Bibcode:1997FEBSL.417...85R. doi:10.1016/s0014-5793(97)01261-1. PMID   9395080. S2CID   27800700.