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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication used to treat and prevent blood clots. Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. It is taken by mouth.
Eculizumab, sold under the brand name Soliris among others, is a recombinant humanized monoclonal antibody used to treat paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, and neuromyelitis optica. In people with paroxysmal nocturnal hemoglobinuria, it reduces both the destruction of red blood cells and need for blood transfusion, but does not appear to affect the risk of death. Eculizumab was the first medication approved for each of its uses, and its approval was granted based on small trials. It is given by intravenous infusion. It is a humanized monoclonal antibody functioning as a terminal complement inhibitor. It binds to the complement C5 protein and inhibits activation of the complement system, a part of the body's immune system. This binding prevents the breakdown of red blood cells in the bloodstream in people with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
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Direct factor Xa inhibitors (xabans) are anticoagulants, used to both treat and prevent blood clots in veins, and prevent stroke and embolism in people with atrial fibrillation (AF).
MorphoSys AG is a German biopharmaceutical company founded in 1992. The company is headquartered near Munich, Germany, and has a wholly owned subsidiary, MorphoSys US Inc., in Boston, Massachusetts, in the US. The company has various antibody, protein and peptide technologies that it uses to discover and develop both proprietary and partnered drug candidates. The company has more than 100 drugs in its wider pipeline that are being investigated for a variety of diseases. While many of these are being developed in partnership with pharma and biotech companies, MorphoSys also has a proprietary pipeline with a focus on cancer and autoimmune diseases.
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers.
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Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. It has not been found to be useful for other factor Xa inhibitors. It is given by injection into a vein.
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Four drugs from the class of direct Xa inhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. The second one was apixaban (Eliquis), approved in Europe in 2011 and in the United States in 2012. The third one edoxaban was approved in Japan in 2011 and in Europe and the US in 2015. Betrixaban (Bevyxxa) was approved in the US in 2017.
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Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. It is designed to bind to and prevent the activation of Complement component 5 (C5).
BeiGene, Ltd. is a multinational oncology company. It specializes in the development of drugs for cancer treatment. Founded in 2010 by chief executive officer John V. Oyler and Xiaodong Wang, the company is headquartered in Cambridge, Massachusetts and has offices in North America, Europe, South America, Asia and Australia. BeiGene has a large presence in the Chinese market. BeiGene has developed several pharmaceuticals, including tislelizumab, a checkpoint inhibitor, and zanubrutinib, a Bruton's tyrosine kinase inhibitor. On 14 November, 2024 the company announced its intention to rebrand as BeOne Medicines.
References
- 1 2 3 4 "FORM 10-K For the Fiscal Year Ended December 31, 2018". portola.com. Retrieved May 13, 2019.
- ↑ "Corporate site". portola.com. Retrieved May 11, 2019.
- ↑ Alexion to Acquire Portola, businesswire.com, Retrieved 5 May 2020.
- ↑ "EX-3.2". sec.gov.
- ↑ "Portola Pharmaceuticals prices upsized IPO at $14.50, within the range"
- ↑ "Novartis gains worldwide rights to elinogrel, a Phase II anti-clotting compound". pharmanews.eu. Retrieved November 3, 2018.
- ↑ "Collaborations, Portola Website" . Retrieved May 11, 2019.
- ↑ Godoy, Jody (August 11, 2021). "Portola Pharmaceuticals, underwriters lose bid to toss shareholder lawsuit". Reuters– via reuters.com.
- ↑ "Judge Dismisses Securities Claims As Lacking In Drug Company's Stock-Drop Suit - Lexis Legal News". lexislegalnews.com.
- ↑ "REMOTE HEARINGS". apps.cand.uscourts.gov.
- ↑ "Securities Settlement Approved in Class Action Against Portola Pharmaceuticals | Law Street Media". November 1, 2022.
- ↑ https://www.bermantabacco.com/wp-content/uploads/2022/12/portolapharmaceuticals-notice.pdf [ bare URL PDF ]
- ↑ "FDA Approval Letter - ANDEXXA, May 3, 2018". fda.gov. Retrieved May 11, 2019.
- ↑ "EMA Positive Opinion - ONDEXXYA, March 1, 2019". ema.europa.eu. Retrieved May 11, 2019.
- ↑ "European Commission Grants Conditional Marketing Authorization for Portola Pharmaceuticals' Ondexxya™ (andexanet alfa), the First and Only Antidote for the Reversal of Factor Xa Inhibitors, PM Portola, April 26, 2019". portola.com. Archived from the original on April 27, 2019. Retrieved May 11, 2019.
- ↑ "FDA approved betrixaban (BEVYXXA, Portola) for the prophylaxis of venous thromboembolism (VTE) in adult patients, FDA, June 23, 2017". fda.gov. November 3, 2018. Retrieved May 11, 2019.
- ↑ "NASDAQ: Portola's (PTLA) Lymphoma Candidate Gets Orphan Drug Status, September 26, 2018". nasdaq.com. Retrieved May 11, 2019.
