Protein geranylgeranyltransferase type I

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CAAX-protein geranylgeranyltransferase
Identifiers
EC no. 2.5.1.59
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a protein geranylgeranyltransferase type I (EC 2.5.1.59) is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate + protein-cysteine S-geranylgeranyl-protein + diphosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.

Structural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1S63, 1S64, 1SA4, 1SA5, 1TNB, 1TNO, 1TNU, 1TNY, 1TNZ, 1X81, 2BED, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, and 2IEJ.

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References