Squalene methyltransferase

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Squalene methyltransferase
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EC no. 2.1.1.262
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Squalene methyltransferase (EC 2.1.1.262, TMT-1, TMT-2) is an enzyme with systematic name S-adenosyl-L-methionine:squalene C-methyltransferase. [1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + squalene 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (overall reaction)
(1a) S-adenosyl-L-methionine + squalene S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene

There are two isoforms in the green alga Botryococcus braunii BOT22 that differ in their specificity .

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References

  1. ↑ Niehaus TD, Kinison S, Okada S, Yeo YS, Bell SA, Cui P, Devarenne TP, Chappell J (March 2012). "Functional identification of triterpene methyltransferases from Botryococcus braunii race B". The Journal of Biological Chemistry. 287 (11): 8163–73. doi: 10.1074/jbc.m111.316059 . PMC   3318757 . PMID   22241476.
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