Sutterella | |
---|---|
Scientific classification | |
Domain: | |
Phylum: | |
Class: | |
Order: | |
Family: | |
Genus: | Sutterella Wexler et al. 1996 [1] |
Type species | |
Sutterella wadsworthensis [1] | |
Species | |
Sutterella megalosphaeroides Contents |
Sutterella is a genus of Gram-negative, rod-shaped, non-spore-forming, Betaproteobacteria whose species have been isolated from the human gastrointestinal tract as well as canine feces. [2] [3] The genus of the family Sutterellaceae currently encompasses 4 distinct species, though at least 5 additional species have been proposed that do not yet meet International Code of Nomenclature of Prokaryotes (ICNP) standards for classification. [4] [5] Sutterella are frequently referred to as commensal in the context of human hosts, but are associated with inflammation, [6] [7] which has implications for a number of diseases.
Sutterella cells are 0.5 to 1 μm wide and 1 to 3 μm long. They exhibit bile resistance, are nitrate reducers, do not hydrolyze urea, and do not possess the cytochrome c oxidase enzyme. They are only able to be cultured in microaerophilic and anaerobic environments. [3] The Sutterella genome encodes the sulfite reductase MccA. [8]
Imbalances in abundance of Sutterella species is correlated with a number of disordered health outcomes. Many of these are related to gut health though others are developmental and neurological disorders. Sutterella abundance has been positively correlated with irritable bowel disease, Crohn's disease, [9] and autism spectrum disorder. [10] [11] Some studies have shown correlation between Sutterella abundance and severity of down syndrome, though not the onset of the syndrome itself. [12] There is also some evidence to suggest that Sutterella may be implicated in the pathogensis of ulcerative colitis. [9] However, Sutterella abundance is negatively associated with other disorders, such as multiple sclerosis. [13]
Sutterella has been found to be mildly pro-inflammatory [6] [7] and some research suggests this is due to an ability to degrade IgA. [14] [15] This may help explain its role in human health.
There have been a number of studies indicating that diet has an effect on Sutterella abundance in the gut. Prebiotics, [16] including artificial sweeteners, [17] pectic polysaccharides, [7] and dietary fiber, [18] have been shown to alter the abundance of Sutterella species.
Sutterella was initially characterized by Wexler et. al. in 1996. Despite being mistaken for Campylobacter gracilis , it was later determined that it had a number of distinguishing features; sequencing confirmed that it was a unique species most closely related to members of the order Burkholderiales and other Betaproteobacteria. This original strain was named Sutterella wadsworthensis , chosen to honor both the laboratory where it was discovered, the Wadsworth Anaerobe Laboratory, and its decades long director, Vera Sutter. [19] [3]
In 2010, upon the discovery of the second species of Parasutterella , Parasutterella secunda , Morotomi et. al. proposed the reclassification of the closely related Sutterella and Parasutterella genera from Alcaligenaceae to a new and distinct family they named Sutterellaceae. [2]
Sutterella megalosphaeroides [20] [21] [5] [22]
Sutterella parvirubra [23] [24] [5] [22]
Sutterella faecalis [28] [5] [22]
Sutterella massiliensis [29] [5] [22]
Candidatus Sutterella merdavium [30] [5] [22]
Acidobacteriota is a phylum of Gram-negative bacteria. Its members are physiologically diverse and ubiquitous, especially in soils, but are under-represented in culture.
Thermus is a genus of thermophilic bacteria. It is one of several bacteria belonging to the Deinococcota phylum. Thermus species can be distinguished from other genera in the family Thermaceae as well as all other bacteria by the presence of eight conserved signature indels (CSIs) found in proteins such as adenylate kinase and replicative DNA helicase as well as 14 conserved signature proteins (CSPs) that are exclusively shared by members of this genus.
Ensifer is a genus of nitrogen-fixing bacteria (rhizobia), three of which have been sequenced.
Collimonas is a genus of bacteria in the family Oxalobacteraceae. Culturable representatives of this genus have the ability to lyse chitin, to use fungal hyphae as a source of food, to produce antifungal molecules and to be effective at weathering.
Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, Gram-positive gut microbes. One or more species in this genus are found in significant numbers in the human gut microbiota. The type species is R. flavefaciens. As usual, bacteria taxonomy is in flux, with Clostridia being paraphyletic, and some erroneous members of Ruminococcus being reassigned to a new genus Blautia on the basis of 16S rRNA gene sequences.
Akkermansia is a genus in the phylum Verrucomicrobiota (Bacteria). The genus was first proposed by Derrien et al. (2004), with the type species Akkermansia muciniphila.
Alistipes is a Gram-negative genus of rod-shaped anaerobic bacteria in the phylum Bacteroidota. When members of this genus colonize the human gastrointestinal (GI) tract, they provide protective effects against colitis, autism, and cirrhosis. However, this genus can also cause dysbiosis by contributing to anxiety, chronic fatigue syndrome, depression, and hypertension. Showcasing priority effects in microbiome assembly, when infant GI tracts have bacteria of the species Staphylococcus but not the species Faecalibacterium, Alistipes species become less capable of colonization. Alistipes, typically benign in the gut, can sometimes trigger infections like intra-abdominal abscesses and bloodstream infections, emphasizing the fine line between symbiosis and disease. This underscores the significance of comprehending their impact on human health within microbial ecosystems.
Parasutterella is a genus of Gram-negative, circular/rod-shaped, obligate anaerobic, non-spore forming bacteria from the Pseudomonadota phylum, Betaproteobacteria class and the family Sutterellaceae. Previously, this genus was considered "unculturable," meaning that it could not be characterized through conventional laboratory techniques, such as grow in culture due its unique requirements of anaerobic environment. The genus was initially discovered through 16S rRNA sequencing and bioinformatics analysis. By analyzing the sequence similarity, Parasutterella was determined to be related most closely to the genus Sutterella and previously classified in the family Alcaligenaceae.
Erythrobacteraceae is a bacterium family in the order of Sphingomonadales.
Christensenella is a genus of non-spore-forming, anaerobic, and nonmotile bacteria from the family Christensenellaceae. They are also part of the order Clostridiales, the class Clostridia and the phylum Firmicutes. Phylogenetic analyzes of 16S rRNA gene sequences are used to describe this family. Due to the recent discovery of the Christensenellaceae family, it was not given importance until a few years ago. This is why very little is known about its ecology and how it may be associated with host factors and other microbiota. However, recent studies establish that members of this family, with exceptions, may be associated with a healthy phenotype for humans. The species C. minuta has been published and validated, and C. timonensis and C. massiliensis have been proposed as novel species of the genus Christensenella, all isolated from human feces.
Azospirillum is a Gram-negative, microaerophilic, non-fermentative and nitrogen-fixing bacterial genus from the family of Rhodospirillaceae. Azospirillum bacteria can promote plant growth.
Mucilaginibacter is a genus from the family of Sphingobacteriaceae.
Parabacteroides is a Gram-negative, anaerobic, non-spore-forming genus from the family Tannerellaceae.
Butyricicoccus is a bacterial genus from the family of Oscillospiraceae., formerly ranked in the family of Clostridiaceae.
Brachybacterium is a genus of Gram positive, nonmotile bacteria. The cells are coccoid during the stationary phase, and irregular rods during the exponential phase. The genus name comes from Greek word brachy, meaning short, and Latin bacterium, meaning rods, referencing the short rods noted during the exponential phase.
Phytobacter is a genus of Gram-negative bacteria emerging from the grouping of isolates previously assigned to various genera of the family Enterobacteriaceae. This genus was first established on the basis of nitrogen fixing isolates from wild rice in China, but also includes a number of isolates obtained during a 2013 multi-state sepsis outbreak in Brazil and, retrospectively, several clinical strains isolated in the 1970s in the United States that are still available in culture collections, which originally were grouped into Brenner's Biotype XII of the Erwinia herbicola-Enterobacter agglomerans-Complex (EEC). Standard biochemical evaluation panels are lacking Phytobacter spp. from their database, thus often leading to misidentifications with other Enterobacterales species, especially Pantoea agglomerans. Clinical isolates of the species have been identified as an important source of extended-spectrum β-lactamase and carbapenem-resistance genes, which are usually mediated by genetic mobile elements. Strong protection of co-infecting sensitive bacteria has also been reported. Bacteria belonging to this genus are not pigmented, chemoorganotrophic and able to fix nitrogen. They are lactose fermenting, cytochrome-oxidase negative and catalase positive. Glucose is fermented with the production of gas. Colonies growing on MacConkey agar (MAC) are circular, convex and smooth with non-entire margins and a usually elevated center. Three species are currently validly included in the genus Phytobacter, which is still included within the Kosakonia clade in the lately reviewed family of Enterobacteriaceae. The incorporation of a fourth species, Phytobacter massiliensis, has recently been proposed via the unification of the genera Metakosakonia and Phytobacter.
Sediminibacillus is a genus of bacteria from the family of Bacillaceae. Sediminibacillus species are halophilic bacteria and found in salty human stools and marine sponges. Sediminibacillus species are identified from Plakortis dariae sponge of the Saint Martin's island of the Bay of Bengal, Bangladesh.
Oscillospiraceae is a family of bacteria in the class Clostridia. All Oscillospiraceae are obligate anaerobes. However, members of the family have diverse shapes, with some rod-shaped and others cocci.
Butyricimonas is a Gram-negative and anaerobic genus of bacteria from the family of Odoribacteraceae. Bacteria in this genus are present in the gastrointestinal tract of various mammals such as rats and humans.
Tumebacillus is a genus of Gram-positive, rod-shaped, spore-forming bacteria. Members of the genus can be motile or non-motile, and form white or yellow colonies on R2A agar.