TRADD

TRADD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F2H, 1F3V
Identifiers
Aliases	TRADD , Hs.89862, TNFRSF1A associated via death domain
External IDs	OMIM: 603500 MGI: 109200 HomoloGene: 2807 GeneCards: TRADD
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 67,154,185 bp [1] End 67,159,909 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.04 cM Start 105,984,918 bp [2] End 105,991,241 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right uterine tube amniotic fluid parotid gland blood palpebral conjunctiva spleen minor salivary gland right coronary artery bronchial epithelial cell Top expressed in intestinal villus left colon jejunum plantaris muscle extensor digitorum longus muscle duodenum blood Epithelium of stomach crypt of lieberkuhn of small intestine mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death domain binding kinase binding protein binding identical protein binding tumor necrosis factor receptor binding protein-containing complex binding molecular adaptor activity transmembrane receptor protein tyrosine kinase adaptor activity Cellular component cytoplasm cytosol receptor complex plasma membrane death-inducing signaling complex membrane raft cytoskeleton nucleus protein-containing complex Biological process extrinsic apoptotic signaling pathway positive regulation of hair follicle development regulation of tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway death-inducing signaling complex assembly positive regulation of NF-kappaB transcription factor activity positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of extrinsic apoptotic signaling pathway via death domain receptors I-kappaB kinase/NF-kappaB signaling activation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors protein heterooligomerization positive regulation of cell migration positive regulation of inflammatory response cellular response to tumor necrosis factor positive regulation of NIK/NF-kappaB signaling transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8717 71609 Ensembl ENSG00000102871 ENSMUSG00000031887 UniProt Q15628 Q3U0V2 RefSeq (mRNA) NM_003789 NM_153425 NM_001323552 NM_001033161 RefSeq (protein) NP_001310481 NP_003780 NP_001028333 Location (UCSC) Chr 16: 67.15 – 67.16 Mb Chr 8: 105.98 – 105.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. ^{[5] [6]}

TRADD is an adaptor protein.

Function

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. ^[6]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions

TRADD has been shown to interact with:

• FADD, ^{[7] [8] [9]}
• Keratin 18 ^[10]
• RIPK1, ^[11]
• STAT1, ^[12]
• TNFRSF1A, ^{[7] [11] [13] [14] [15] [16] [17]}
• TNFRSF25, ^[18] and
• TRAF2. ^{[7] [19] [20] [21] [22] [23] [24]}

See also

• TRAF
• RIP

References

1. GRCh38: Ensembl release 89: ENSG00000102871 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031887 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu H, Xiong J, Goeddel DV (June 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell. 81 (4): 495–504. doi: 10.1016/0092-8674(95)90070-5 . PMID   7758105. S2CID   14301562.
6. "Entrez Gene: TRADD TNFRSF1A-associated via death domain".
7. Hsu H, Shu HB, Pan MG, Goeddel DV (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell. 84 (2): 299–308. doi: 10.1016/s0092-8674(00)80984-8 . PMID   8565075. S2CID   13171355.
8. Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP (September 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". J. Neurochem. 86 (5): 1260–70. doi: 10.1046/j.1471-4159.2003.01934.x . PMID   12911633. S2CID   21971958.
9. Thomas LR, Stillman DJ, Thorburn A (September 2002). "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen". J. Biol. Chem. 277 (37): 34343–8. doi: 10.1074/jbc.M204169200 . PMID   12107169.
10. Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T, Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155 (3): 415–26. doi:10.1083/jcb.200103078. PMC   2150850 . PMID   11684708.
11. Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity. 4 (4): 387–96. doi: 10.1016/s1074-7613(00)80252-6 . PMID   8612133.
12. Wang Y, Wu TR, Cai S, Welte T, Chin YE (July 2000). "Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation". Mol. Cell. Biol. 20 (13): 4505–12. doi:10.1128/mcb.20.13.4505-4512.2000. PMC   85828 . PMID   10848577.
13. Jiang Y, Woronicz JD, Liu W, Goeddel DV (January 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science. 283 (5401): 543–6. doi:10.1126/science.283.5401.543. PMID   9915703.
14. Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse ML, Heinrich M, Wickel M, Krönke M (April 1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi: 10.1074/jbc.274.15.10203 . PMID   10187805.
15. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID   9082980. S2CID   19984057.
16. Shu HB, Takeuchi M, Goeddel DV (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi: 10.1073/pnas.93.24.13973 . PMC   19479 . PMID   8943045.
17. Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D (January 2009). "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)". Biochem. J. 417 (1): 149–60. doi:10.1042/BJ20081885. PMID   18939944.
18. Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (November 1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. doi:10.1038/384372a0. PMID   8934525. S2CID   4283742.
19. Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
20. Takeuchi M, Rothe M, Goeddel DV (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi: 10.1074/jbc.271.33.19935 . PMID   8702708.
21. Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H (June 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell. 101 (7): 777–87. doi: 10.1016/s0092-8674(00)80889-2 . PMID   10892748. S2CID   5928713.
22. Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL (June 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell. 5 (6): 1051–7. doi: 10.1016/s1097-2765(00)80270-1 . PMID   10911999.
23. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakano H (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. 276 (39): 36530–4. doi: 10.1074/jbc.M104837200 . PMID   11479302.
24. Malinin NL, Boldin MP, Kovalenko AV, Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature. 385 (6616): 540–4. doi:10.1038/385540a0. PMID   9020361. S2CID   4366355.

Further reading

• Baker SJ, Reddy EP (1999). "Modulation of life and death by the TNF receptor superfamily". Oncogene. 17 (25): 3261–70. doi: 10.1038/sj.onc.1202568 . PMID   9916988.
• Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell. 84 (2): 299–308. doi: 10.1016/S0092-8674(00)80984-8 . PMID   8565075. S2CID   13171355.
• Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity. 4 (4): 387–96. doi: 10.1016/S1074-7613(00)80252-6 . PMID   8612133.
• Boldin MP, Goncharov TM, Goltsev YV, Wallach D (1996). "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death". Cell. 85 (6): 803–15. doi: 10.1016/S0092-8674(00)81265-9 . PMID   8681376. S2CID   7415784.
• Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi: 10.1074/jbc.271.33.19935 . PMID   8702708.
• Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. doi:10.1038/384372a0. PMID   8934525. S2CID   4283742.
• Shu HB, Takeuchi M, Goeddel DV (1997). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi: 10.1073/pnas.93.24.13973 . PMC   19479 . PMID   8943045.
• Izumi KM, Kieff ED (1997). "The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12592–7. doi: 10.1073/pnas.94.23.12592 . PMC   25049 . PMID   9356494.
• Wajant H, Johannes FJ, Haas E, Siemienski K, Schwenzer R, Schubert G, Weiss T, Grell M, Scheurich P (1998). "Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction". Curr. Biol. 8 (2): 113–6. doi: 10.1016/S0960-9822(98)70042-9 . PMID   9427646. S2CID   6269984.
• Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821–30. doi: 10.1016/S1074-7613(00)80400-8 . PMID   9430227.
• Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Lett. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. hdl: 2027.42/116991 . PMID   9714541. S2CID   11151198.
• Jones SJ, Ledgerwood EC, Prins JB, Galbraith J, Johnson DR, Pober JS, Bradley JR (1999). "TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1". J. Immunol. 162 (2): 1042–8. PMID   9916731.
• Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse ML, Heinrich M, Wickel M, Krönke M (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi: 10.1074/jbc.274.15.10203 . PMID   10187805.
• Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation". EMBO J. 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMC   1171386 . PMID   10356400.
• Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. doi: 10.1074/jbc.274.29.20127 . PMID   10400625.
• Wang Y, Wu TR, Cai S, Welte T, Chin YE (2000). "Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation". Mol. Cell. Biol. 20 (13): 4505–12. doi:10.1128/MCB.20.13.4505-4512.2000. PMC   85828 . PMID   10848577.
• Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H (2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell. 101 (7): 777–87. doi: 10.1016/S0092-8674(00)80889-2 . PMID   10892748. S2CID   5928713.
• Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL (2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell. 5 (6): 1051–7. doi: 10.1016/S1097-2765(00)80270-1 . PMID   10911999.

External links

• TRADD+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)