TRNA (guanine10-N2)-dimethyltransferase

TRNA (guanine10-N2)-dimethyltransferase
Identifiers
EC no.	2.1.1.213
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (guanine¹⁰-N²)-dimethyltransferase (EC 2.1.1.213, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine¹⁰-N²)-dimethyltransferase. ^[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + guanine¹⁰ in tRNA ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA (overall reaction)

(1a) S-adenosyl-L-methionine + guanine¹⁰ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N²-methylguanine¹⁰ in tRNA

(1b) S-adenosyl-L-methionine + N²-methylguanine¹⁰ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA

References

1. Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H (August 2004). "N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota" (PDF). The Journal of Biological Chemistry. 279 (35): 37142–52. doi: 10.1074/jbc.m403845200 . PMID   15210688.

External links

• TRNA+(guanine10-N2)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)