Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Identifiers
EC no. 5.3.3.17
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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase (EC 5.3.3.17, phzF (gene)) is an enzyme with systematic name (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate

The enzyme is involved in phenazine biosynthesis.

References

  1. ↑ Parsons JF, Song F, Parsons L, Calabrese K, Eisenstein E, Ladner JE (October 2004). "Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79". Biochemistry. 43 (39): 12427–35. doi:10.1021/bi049059z. PMID   15449932.
  2. ↑ Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV (November 2004). "Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens". Proceedings of the National Academy of Sciences of the United States of America. 101 (47): 16431–6. Bibcode:2004PNAS..10116431B. doi: 10.1073/pnas.0407371101 . PMC   534541 . PMID   15545603.
  3. ↑ Parsons JF, Calabrese K, Eisenstein E, Ladner JE (November 2004). "Structure of the phenazine biosynthesis enzyme PhzG" (PDF). Acta Crystallographica Section D. 60 (Pt 11): 2110–3. doi: 10.1107/s0907444904022474 . PMID   15502343.
  4. ↑ Mavrodi DV, Bleimling N, Thomashow LS, Blankenfeldt W (January 2004). "The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79". Acta Crystallographica Section D. 60 (Pt 1): 184–6. Bibcode:2004AcCrD..60..184M. doi:10.1107/s090744490302571x. PMID   14684924.
  5. ↑ Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W (December 2008). "PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis". Journal of the American Chemical Society. 130 (50): 17053–61. Bibcode:2008JAChS.13017053A. doi:10.1021/ja806325k. PMID   19053436.
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