Trans-2-decenoyl-(acyl-carrier protein) isomerase

Trans-2-decenoyl-(acyl-carrier protein) isomerase
Identifiers
EC no.	5.3.3.14
CAS no.	9030-80-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a trans-2-decenoyl-[acyl-carrier protein] isomerase (EC 5.3.3.14) is an enzyme that catalyzes the chemical reaction

trans-dec-2-enoyl-[acyl-carrier-protein] ${\displaystyle \rightleftharpoons }$ cis-dec-3-enoyl-[acyl-carrier-protein]

Hence, this enzyme has one substrate, [[trans-dec-2-enoyl-[acyl-carrier-protein]]], and one product, [[cis-dec-3-enoyl-[acyl-carrier-protein]]].

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase. Other names in common use include beta-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, and FabM.

References

• Brock DJ, Kass LR, Bloch K (1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–40. doi: 10.1016/S0021-9258(18)99557-8 . PMID   4863740.
• Bloch K (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2 (7): 193–202. doi:10.1021/ar50019a001.
• Marrakchi H, Choi KH, Rock CO (2002). "A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae". J. Biol. Chem. 277 (47): 44809–16. doi: 10.1074/jbc.M208920200 . PMID   12237320.
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.