Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used: an inactivated poliovirus given by injection (IPV) and a weakened poliovirus given by mouth (OPV). The World Health Organization (WHO) recommends all children be fully vaccinated against polio. The two vaccines have eliminated polio from most of the world, and reduced the number of cases reported each year from an estimated 350,000 in 1988 to 33 in 2018.
John Franklin Enders was an American biomedical scientist and Nobel Laureate. Enders has been called "The Father of Modern Vaccines."
Albert Bruce Sabin was a Polish-American medical researcher, best known for developing the oral polio vaccine, which has played a key role in nearly eradicating the disease. In 1969–72, he served as the president of the Weizmann Institute of Science in Israel.
Leonard Andrew Scheele was an American physician and public servant. He was appointed the seventh Surgeon General of the United States from 1948 to 1956.
Herald Rea Cox (1907–1986) was an American bacteriologist. The bacterial family Coxiellaceae and the genus Coxiella, which include the organism that causes Q fever, are named after him.
Parke-Davis is a subsidiary of the pharmaceutical company Pfizer. Although Parke, Davis & Co. is no longer an independent corporation, it was once America's oldest and largest drug maker, and played an important role in medical history. In 1970 Parke-Davis was acquired by Warner–Lambert, which in turn was acquired by Pfizer in 2000.
Thomas Francis Jr. was an American physician, virologist, and epidemiologist who guided the discovery and development of the polio vaccine being worked on by his student Jonas Salk. Francis was the first person to isolate influenza virus in the United States, and in 1940 showed that there are other strains of influenza, and took part in the development of influenza vaccines.
The Michigan Walk of Fame, styled on the famous Hollywood Walk of Fame, honors Michigan residents, past or present, who have made significant contributions to the state or nation.
Cutter Laboratories was a family-owned pharmaceutical company located in Berkeley, California, founded by Edward Ahern Cutter in 1897. Cutter's early products included anthrax vaccine, hog cholera virus, and anti-hog cholera serum—and eventually a hog cholera vaccine. The hog cholera vaccine was the first tissue culture vaccine, human or veterinary, ever produced. The company expanded considerably during World War II as a consequence of government contracts for blood plasma and penicillin. After Edward Cutter's death, his three sons—Robert K. Cutter (president), Edward "Ted" A. Cutter Jr. (vice-president), and Frederick A. Cutter—ran the company. In the next generation Robert's son David followed his father as president of the company. The Bayer pharmaceutical company bought Cutter Laboratories in 1974.
The history of polio (poliomyelitis) infections began during prehistory. Although major polio epidemics were unknown before the 20th century, the disease has caused paralysis and death for much of human history. Over millennia, polio survived quietly as an endemic pathogen until the 1900s when major epidemics began to occur in Europe. Soon after, widespread epidemics appeared in the rest of the world. By 1910, frequent epidemics became regular events throughout the developed world primarily in cities during the summer months. At its peak in the 1940s and 1950s, polio would paralyze or kill over half a million people worldwide every year.
Jonas Salk Hall at the University of Pittsburgh is a Pennsylvania state and Pittsburgh History and Landmarks Foundation Historic Landmark. The Art Deco building is named after Jonas Salk, who conducted his research on the first polio vaccine in a basement laboratory while on the faculty at the University of Pittsburgh.
An inactivated vaccine is a type of vaccine that contains pathogens that have been killed or rendered inactive, so they cannot replicate or cause disease. In contrast, live vaccines use pathogens that are still alive. Pathogens for inactivated vaccines are grown under controlled conditions and are killed as a means to reduce infectivity and thus prevent infection from the vaccine.
Jonas Edward Salk was an American virologist and medical researcher who developed one of the first successful polio vaccines. He was born in New York City and attended the City College of New York and New York University School of Medicine.
The University of Michigan Institute for Social Research (ISR) is the largest academic social research and survey organization in the world, established in 1949. ISR includes more than 300 scientists from a variety of academic disciplines – including political science, psychology, sociology, economics, demography, history, anthropology, and statistics. The institute is a unit that houses five separate but interdependent centers which conduct research and maintain data archives. In 2021, Kathleen Cagney became the first woman in its history to be named Director of the institute.
Herbert Spencer Ratner, was an American physician. He taught and wrote on the philosophy and history of medicine and was a popular lecturer on marriage and the family. Ratner was the director of public health for the community of Oak Park, Illinois, for twenty-five years. An advocate of preventive family medicine based on natural norms, he was also a long-time proponent of informed medical consent, and played a pivotal role in the polio vaccine controversy beginning in 1955. For more than twenty-nine years Ratner was editor of Child and Family Quarterly, a paramedical journal which ran articles on the Hippocratic Oath, infant development, women’s health, and other topics related to family health.
Henry Frieze Vaughan was an American epidemiologist with a strong discipline in environmental health, an academic professor, and an administrator. Among the positions he held, he was the Health Commissioner for the City of Detroit (1919–1941), editor for “American Journal of Public Health” (1922–1924), President of American Public Health in 1925, trustee of the W. K. Kellogg Foundation (1933–1978), President of Council at the Michigan Department of Council (1939–1960), founder and Dean of the University of Michigan School of Public Health (1941–1960), and the co-founder and first president of the National Sanitation Foundation (1944–1966). Vaughan was born in Michigan and stayed in Michigan for most of his life contributing to the development and innovation of medical and health services in Michigan.
Julius S. Youngner was an American Distinguished Service Professor in the School of Medicine and Department of Microbiology & Molecular Genetics at University of Pittsburgh responsible for advances necessary for development of a vaccine for poliomyelitis and the first intranasal equine influenza vaccine.
Howard Atkinson Howe was an American physician, whose work at the Johns Hopkins medical institutions helped to lay the groundwork for the Salk polio vaccine.
The announcement of the polio vaccine's safety and effectiveness was on April 12, 1955, by Thomas Francis, Jr., of the University of Michigan, the monitor of the test results. Within minutes of his announcement to the audience of scientists and reporters, news of the event was carried coast to coast by wire services and radio and television newscasts. When the vaccine was announced as successful, it led to spontaneous celebrations across the United States. It was the world's first successful polio vaccine, declared "safe, effective, and potent." It was possibly the most significant biomedical advance of the twentieth century.
Elsie N. Ward was a microbiologist who contributed to the development of a polio vaccine through her work in Jonas Salk's Virus Research Laboratory at the University of Pittsburgh. Ward's role was to grow poliovirus in monkey tissues.
