WAY-213,613

Last updated
WAY-213,613
WAY-213,613 structure.png
Identifiers
  • (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.212.988 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C16H13BrF2N2O4
Molar mass 415.191 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F
  • InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1 X mark.svgN
  • Key:BNYDDAAZMBUFRG-ZDUSSCGKSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors. [1] It is used in scientific research into the function of the glutamate transporters. [2]

References

  1. ↑ Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, et al. (October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID   16014807. S2CID   24207924.
  2. ↑ Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P (July 2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID   19364521. S2CID   23641405.
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