Azapropazone

Last updated
Azapropazone
Azapropazone.svg
Azapropazone 3D spacefill.png
Clinical data
Trade names Rheumox
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Elimination half-life 20 hours
Identifiers
  • (RS)-5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.033.543 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C16H20N4O2
Molar mass 300.362 g·mol−1
3D model (JSmol)
Chirality Racemic mixture
  • O=C3N/1N(c2c(\N=C\1N(C)C)ccc(c2)C)C(=O)C3CCC
  • InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3 Yes check.svgY
  • Key:MPHPHYZQRGLTBO-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox. [1]

It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects. [2] Azopropazone has now been discontinued in the British National Formulary.

Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized. [3]

Related Research Articles

<span class="mw-page-title-main">Heroin</span> Opioid used as a recreational drug for its euphoric effects

Heroin, also known as diacetylmorphine and diamorphine among other names, is a morphinan opioid substance synthesized from the dried latex of the Papaver somniferum plant and is mainly used as a recreational drug for its euphoric effects. Medical-grade diamorphine is used as a pure hydrochloride salt. Various white and brown powders sold illegally around the world as heroin are routinely diluted with cutting agents. Black tar heroin is a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is the result of crude acetylation during clandestine production of street heroin. Heroin is used medically in several countries to relieve pain, such as during childbirth or a heart attack, as well as in opioid replacement therapy.

<span class="mw-page-title-main">Oxycodone</span> Opioid medication

Oxycodone, sold under various brand names such as Roxicodone and OxyContin, is a semi-synthetic opioid used medically for treatment of moderate to severe pain. It is highly addictive and is a commonly abused drug. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.

<span class="mw-page-title-main">Sildenafil</span> Drug for erectile dysfunction and hypertension

Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. It is unclear if it is effective for treating sexual dysfunction in women. It can be taken orally, intravenously, or sublingually. Onset when taken orally is typically within twenty minutes and lasts for about two hours.

<span class="mw-page-title-main">Khat</span> Psychoactive species of plant

Khat or qat ,(swahili - miraa, jaba, aluta)is a flowering plant native to eastern and southern Africa. Khat contains the alkaloid cathinone, a stimulant which causes greater sociability, excitement, loss of appetite, and mild euphoria. Among communities from the areas where the plant is native, khat-chewing has historical relevance dating back thousands of years, analogous—but slightly different—to the use of coca leaves in South America’s Andes Mountains or the betel nut preparations in South Asia; khat is often chewed socially, to stimulate conversation among groups of men in a lounge, smoking hookah.

<span class="mw-page-title-main">Drug Enforcement Administration</span> United States federal law enforcement agency

The Drug Enforcement Administration is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating illicit drug trafficking and distribution within the U.S. It is the lead agency for domestic enforcement of the Controlled Substances Act, sharing concurrent jurisdiction with the Federal Bureau of Investigation, the U.S. Immigration and Customs Enforcement, and U.S. Customs and Border Protection. However, the DEA has sole responsibility for coordinating and pursuing U.S. drug investigations both domestically and internationally.

<span class="mw-page-title-main">Robert Downey Jr.</span> American actor (born 1965)

Robert John Downey Jr. is an American actor. His career has been characterized by critical success in his youth, followed by a period of substance abuse and legal troubles, and a surge in popular and commercial success later in his career. In 2008, Downey was named by Time magazine among the 100 most influential people in the world, and from 2013 to 2015, he was listed by Forbes as Hollywood's highest-paid actor.

<span class="mw-page-title-main">Quetiapine</span> Atypical antipsychotic medication

Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use do not appear to generally outweigh the side effects. It is taken orally.

<span class="mw-page-title-main">GSK plc</span> British multinational pharmaceutical and biotechnology company

GSK plc is a British multinational pharmaceutical and biotechnology company with global headquarters in London. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham, GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck Sharp & Dohme.

<span class="mw-page-title-main">Alprazolam</span> Benzodiazepine medication

Alprazolam, sold under the brand name Xanax, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. Alprazolam is most commonly used in management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD). Other uses include the treatment of chemotherapy-induced nausea, together with other treatments. GAD improvement occurs generally within a week. Alprazolam is generally taken orally.

ATC code M01Anti-inflammatory and antirheumatic products is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup M01 is part of the anatomical group M Musculo-skeletal system.

<span class="mw-page-title-main">Amy Winehouse</span> English singer and songwriter (1983–2011)

Amy Jade Winehouse was an English singer and songwriter. She was known for her deep, expressive contralto vocals and her eclectic mix of musical genres, including soul, rhythm and blues, reggae and jazz.

<span class="mw-page-title-main">Bromo-DragonFLY</span> Chemical compound

Bromo-DragonFLY is a substance related to the phenethylamine family. It acts as a potent full agonist for the 5-HT2A receptor.

<span class="mw-page-title-main">Benzylpiperazine</span> Recreational drug

Benzylpiperazine (BZP) is a recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity and seizures. Deaths from piperazine derivatives are extremely rare, but there has been at least one death apparently due to BZP alone. Its sale is banned in several countries, including Australia, Canada, New Zealand, the United States, the Republic of Ireland, the United Kingdom, Bulgaria, Romania and other parts of Europe.

<span class="mw-page-title-main">Russell Brand</span> English comedian, actor, and podcaster (born 1975)

Russell Edward Brand is an English presenter, comedian and actor. He is also an activist and campaigner. He has received three British Comedy Awards and nomination for a BAFTA Award.

<span class="mw-page-title-main">Cyclizine</span> Antiemetic/motion sickness

Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. It may also be used for nausea after general anaesthesia or that which developed from opioid use. It is taken by mouth, in the rectum, or injected into a vein.

The legal status of cocaine varies worldwide. Even though many countries have banned the sale of cocaine for recreational use, some have legalized it for possession, personal use, transportation, and cultivation, while some have decriminalized it for certain uses. It is necessary to distinguish cocaine from coca leaves or the plant itself.

<span class="mw-page-title-main">Drug</span> Substance having effect(s) on the body of an individual

A drug is any chemical substance that when consumed causes a change in an organism's physiology, including its psychology, if applicable. Drugs are typically distinguished from food and other substances that provide nutritional support. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue.

<span class="mw-page-title-main">Mephedrone</span> Synthetic stimulant drug

Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone, M-CAT, White Magic, meow meow and bubble. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of tablets or crystals, which users can swallow, snort or inject, producing effects similar to those of MDMA, amphetamines and cocaine.

<span class="mw-page-title-main">The War on Drugs (band)</span> American rock band

The War on Drugs is an American rock band from Philadelphia, Pennsylvania, formed in 2005. The band consists of Adam Granduciel, David Hartley, Robbie Bennett (keyboards), Charlie Hall (drums), Jon Natchez, Anthony LaMarca (guitar) and Eliza Hardy Jones.

<span class="mw-page-title-main">Cannabis in the United Kingdom</span> Use of cannabis in the United Kingdom

Cannabis in the United Kingdom is illegal for recreational use and is classified as a Class B drug. In 2004, the United Kingdom made cannabis a Class C drug with less severe penalties, but it was moved back to Class B in 2009. Medical use of cannabis, when prescribed by a registered specialist doctor, was legalised in November 2018.

References

  1. "Rheumox Capsules". South Africa Electronic Package Inserts. Archived from the original on 2008-05-15. Retrieved 2008-08-18.
  2. "Azapropazone". Patient UK. Archived from the original on 12 April 2009.
  3. Jones CJ (1976). "The pharmacology and pharmacokinetics of azapropazone - a review". Current Medical Research and Opinion. 4 (1): 3–16. doi:10.1185/03007997609109277. PMID   770078.