KRT23

Last updated
KRT23
Identifiers
Aliases KRT23 , CK23, HAIK1, K23, keratin 23
External IDs OMIM: 606194 MGI: 2148866 HomoloGene: 9172 GeneCards: KRT23
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282433
NM_015515
NM_173213

NM_033373

RefSeq (protein)

NP_001269362
NP_056330

NP_203537

Location (UCSC) Chr 17: 40.92 – 40.94 Mb Chr 11: 99.37 – 99.38 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene. [5] [6] [7]

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [7]

Related Research Articles

<span class="mw-page-title-main">Keratin 7</span>

Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene. Keratin 7 is a type II keratin. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

<span class="mw-page-title-main">Keratin 6A</span>

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

<span class="mw-page-title-main">Keratin 4</span>

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

<span class="mw-page-title-main">Keratin 3</span>

Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene. Keratin 3 is a type II cytokeratin. It is specifically found in the corneal epithelium together with keratin 12.

<span class="mw-page-title-main">Keratin 14</span> Protein-coding gene in the species Homo sapiens

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.

<span class="mw-page-title-main">Keratin 13</span> Protein-coding gene in the species Homo sapiens

Keratin 13 is a protein that in humans is encoded by the KRT13 gene.

<span class="mw-page-title-main">Keratin 10</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

<span class="mw-page-title-main">Keratin 9</span> Protein-coding gene in the species Homo sapiens

Keratin 9 is a protein that in humans is encoded by the KRT9 gene.

<span class="mw-page-title-main">Keratin 19</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.

<span class="mw-page-title-main">Keratin 18</span>

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

<span class="mw-page-title-main">Keratin 16</span> Protein-coding gene in the species Homo sapiens

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

<span class="mw-page-title-main">Keratin 15</span> Protein-coding gene in the species Homo sapiens

Keratin 15 is a protein that in humans is encoded by the KRT15 gene.

<span class="mw-page-title-main">Keratin 8</span>

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

<span class="mw-page-title-main">Keratin 5</span>

Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.

<span class="mw-page-title-main">Keratin 6C</span>

Keratin 6C, is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene was uncovered recently by the Human Genome Project and its expression patterns in humans remains unknown.

<span class="mw-page-title-main">KRT78</span>

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

<span class="mw-page-title-main">Keratin 34</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

<span class="mw-page-title-main">KRT36</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

<span class="mw-page-title-main">KRT80</span>

Keratin 80, also known as KRT80, is a protein which humans is encoded by the KRT80 gene.

<span class="mw-page-title-main">KRT79</span>

Keratin 79 also known as KRT79 is a protein which humans is encoded by the KRT79 gene.

References

  1. 1 2 3 ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006777 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID   11135429. S2CID   40237049.
  6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC   2064177 . PMID   16831889.
  7. 1 2 "Entrez Gene: KRT23 keratin 23 (histone deacetylase inducible)".

Further reading