MYO1F

MYO1F
Identifiers
Aliases	MYO1F , myosin IF
External IDs	OMIM: 601480 MGI: 107711 HomoloGene: 56276 GeneCards: MYO1F
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,577,577 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	33,826,738 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow cells; ; right lung; ; appendix; ; upper lobe of left lung; ; sural nerve; ; cancellous bone; ; periodontal fiber;
	Top expressed in
	blood; ; spleen; ; calvaria; ; thymus; ; subcutaneous adipose tissue; ; right lung lobe; ; mammary gland; ; white adipose tissue; ; body of femur; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; actin binding ; cytoskeletal motor activity ; ATP binding ; calmodulin binding ; microtubule motor activity ; microtubule binding ;
Cellular component	unconventional myosin complex ; myosin complex ;
Biological process	biological process ; microtubule-based movement ;
	Sources:Amigo / QuickGO
Orthologs
	4542
	17916
	ENSG00000142347
	ENSMUSG00000024300
	O00160
	P70248
	NM_012335 ; NM_001348355
	NM_053214
	NP_036467 ; NP_001335284
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

Myosin-If is a protein that in humans is encoded by the MYO1F gene.^[5]^[6]^[7]

It is expressed mainly in the immune system and might be involved in cell adhesion and motility.^[8] It is a candidate gene for (among other things) nonsyndromic deafness.^[9]

Related Research Articles

<span class="mw-page-title-main">Myosin</span> Superfamily of motor proteins

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility.

Myosin VIIA is protein that in humans is encoded by the MYO7A gene. Myosin VIIA is a member of the unconventional myosin superfamily of proteins. Myosins are actin binding molecular motors that use the enzymatic conversion of ATP - ADP + inorganic phosphate (Pi) to provide the energy for movement.

Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.

Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. Unconventional myosin-VI is a myosin molecular motor involved in intracellular vesicle and organelle transport.

Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.

MYO9B is a gene that encodes the Myosin-IXb protein.

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.

Calmodulin-like protein 3 is a protein that in humans is encoded by the CALML3 gene.

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

Unconventional myosin-Ia is a protein that in humans is encoded by the MYO1A gene.

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

Myosin-Ib is a protein that in humans is encoded by the MYO1B gene.

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.

Myosin-XV is a protein that in humans is encoded by the MYO15A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
↑ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID 8884266.
↑ "Entrez Gene: MYO1F myosin IF".
↑ Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID 17023661. S2CID 12479761.
↑ Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi: 10.1001/archotol.127.8.921 . PMID 11493199.

Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi: 10.1073/pnas.91.14.6549 . PMC 44240 . PMID 8022818.
Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi: 10.1016/S1097-2765(02)00434-3 . PMID 11804589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119401-5] Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.

[pmid8884266-6] Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID 8884266.

[entrez-7] "Entrez Gene: MYO1F myosin IF".

[pmid17023661-8] Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID 17023661. S2CID 12479761.

[pmid11493199-9] Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi: 10.1001/archotol.127.8.921 . PMID 11493199.

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MYO1F

Related Research Articles

References

Further reading