MYO5B

Last updated
MYO5B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYO5B , myosin VB, MVID1, DIAR2, PFIC10
External IDs OMIM: 606540 MGI: 106598 HomoloGene: 49481 GeneCards: MYO5B
Orthologs
SpeciesHumanMouse
Entrez

4645

17919

Ensembl

ENSG00000167306

ENSMUSG00000025885

UniProt

Q9ULV0

P21271

RefSeq (mRNA)

NM_001080467

NM_008661
NM_201600

RefSeq (protein)

NP_001073936

n/a

Location (UCSC) Chr 18: 49.82 – 50.2 Mb Chr 18: 74.57 – 74.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans. [5] [6] [7] [8]

Contents

Recent evidence suggests that Myosin-Vb is related to the creation of memories [9] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines. [10]

Mutations of MYO5B cause microvillus inclusion disease due to defective trafficking of apical and basolateral proteins. [8]

MYO5B has also been associated with bipolar disorder. [11]

Interactions

MYO5B has been shown to interact with RAB11FIP2. [12]

Related Research Articles

<span class="mw-page-title-main">Melanophilin</span> Protein-coding gene in the species Homo sapiens

Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

<span class="mw-page-title-main">Unconventional myosin-Va</span> Protein-coding gene in the species Homo sapiens

Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.

<span class="mw-page-title-main">RAB5A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.

<span class="mw-page-title-main">RAB11A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

<span class="mw-page-title-main">Unconventional myosin-VI</span>

Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. Unconventional myosin-VI is a myosin molecular motor involved in intracellular vesicle and organelle transport.

<span class="mw-page-title-main">RAB8A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

<span class="mw-page-title-main">MYO9B</span> Protein-coding gene in the species Homo sapiens

MYO9B is a gene that encodes the Myosin-IXb protein.

<span class="mw-page-title-main">RAB11FIP1</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.

<span class="mw-page-title-main">RAB11FIP2</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.

<span class="mw-page-title-main">RAB11FIP5</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

<span class="mw-page-title-main">MYO10</span> Protein-coding gene in the species Homo sapiens

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.

<span class="mw-page-title-main">RAB11FIP3</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.

<span class="mw-page-title-main">RAB22A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

<span class="mw-page-title-main">Unconventional myosin-Ia</span>

Unconventional myosin-Ia is a protein that in humans is encoded by the MYO1A gene.

<span class="mw-page-title-main">RAB25</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of tumor development.

<span class="mw-page-title-main">Myosin-IIIa</span> Protein-coding gene in the species Homo sapiens

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

<span class="mw-page-title-main">RAB11B</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-11B is a protein that in humans is encoded by the RAB11B gene. Rab11b is reported as most abundantly expressed in brain, heart and testes.

<span class="mw-page-title-main">MYO1B</span> Protein-coding gene in the species Homo sapiens

Myosin-Ib is a protein that in humans is encoded by the MYO1B gene.

<span class="mw-page-title-main">RAB27A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

<span class="mw-page-title-main">MYO1E</span> Protein-coding gene in the species Homo sapiens

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167306 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025885 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID   8884266.
  6. ↑ Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA (Aug 2007). "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells". The Journal of Biological Chemistry. 282 (32): 23725–36. doi: 10.1074/jbc.M608531200 . PMID   17462998.
  7. ↑ "Entrez Gene: MYO5B myosin VB".
  8. 1 2 Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR (Oct 2008). "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity". Nature Genetics. 40 (10): 1163–5. doi:10.1038/ng.225. PMID   18724368. S2CID   205345488.
  9. ↑ "DukeHealth.org: Scientists Identify Machinery that Helps Make Memories" . Retrieved 2014-03-25.
  10. ↑ Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, Ehlers MD (Oct 2008). "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity". Cell. 135 (3): 535–48. doi:10.1016/j.cell.2008.09.057. PMC   2585749 . PMID   18984164.
  11. ↑ Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (Jun 2008). "Whole-genome association study of bipolar disorder". Molecular Psychiatry. 13 (6): 558–69. doi:10.1038/sj.mp.4002151. PMC   3777816 . PMID   18317468.
  12. ↑ Hales CM, Vaerman JP, Goldenring JR (Dec 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry. 277 (52): 50415–21. doi: 10.1074/jbc.M209270200 . PMID   12393859.

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